Jackson, Thomas W Ryherd, Garret L Scheibly, Chris M Sasser, Aubrey L Guillette, T C Belcher, Scott M
Published in
Toxicological sciences : an official journal of the Society of Toxicology
There is compelling evidence that developmental exposure to toxic metals increases risk for obesity and obesity-related morbidity including cardiovascular disease and type 2 diabetes. To explore the hypothesis that developmental Cd exposure increases risk of obesity later in life, male, and female CD-1 mice were maternally exposed to 500 ppb CdCl2 ...
Eustache, Florence Bennani Smires, Badria Moison, Delphine Bergès, Raymond Canivenc-Lavier, Marie-Chantal Vaiman, Daniel Auger, Jacques
Living species including humans are continuously exposed to low levels of a myriad of endocrine active compounds that may affect their reproductive function. In contrast, experimental designs scrutinizing this question mostly consider the gestational/lactational period, select high unrealistic doses and, have rarely investigated the possible reprod...
Zorn, Kimberley M Foil, Daniel H Lane, Thomas R Hillwalker, Wendy Feifarek, David J Jones, Frank Klaren, William D Brinkman, Ashley M Ekins, Sean
Published in
Environmental science & technology
The androgen receptor (AR) is a target of interest for endocrine disruption research, as altered signaling can affect normal reproductive and neurological development for generations. In an effort to prioritize compounds with alternative methodologies, the U.S. Environmental Protection Agency (EPA) used in vitro data from 11 assays to construct mod...
Küblbeck, Jenni Niskanen, Jonna Honkakoski, Paavo
Published in
Cells
During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug- and xenobiotic-metabolizing enzymes and transporters that govern the clearance of both exogenous and endogenous small molecules. Recent studies indicate that CAR participates, together with other nuclear receptors (NRs) and tran...
Rehan, Mohd Ahmad, Ejaz Beg, Mohd A
Published in
Journal of applied toxicology : JAT
Globally, more than a billion people smoke tobacco making it one of the biggest public health problems and a leading risk factor for global deaths. Nicotine, the main alkaloid in tobacco, has been shown to be associated with fertility problems in men and women. The adverse effects of tobacco/nicotine on reproduction have been attributed to deleteri...
Kingsley, Okpara Witthayawirasak, Banchong
Published in
Toxics
Phthalate esters (PAEs) are well known for their environmental contamination and endocrine-disrupting effects on wildlife and humans. In this study, the occurrence of PAEs and ecotoxicological risk assessments were performed in one of the significant canals in southern Thailand, named U-Tapao. Water samples were collected and analyzed for the six m...
Almstrup, Kristian Frederiksen, Hanne Andersson, Anna-Maria Juul, Anders
Published in
Endocrine connections
Puberty marks a transition period, which leads to the attainment of adult sexual maturity. Timing of puberty is a strongly heritable trait. However, large genetic association studies can only explain a fraction of the observed variability and striking secular trends suggest that lifestyle and/or environmental factors are important. Using liquid-chr...
Petric, Zvonimir Ružić, Julia Žuntar, Irena
Published in
Acta Pharmaceutica
Effects of paraben toxicity, i.e., endocrine-disruption properties, are in the focus of researchers for decades, but still – they are a hot subject of debate. Parabens are aliphatic esters of p-hydroxybenzoic acid, which are widely used as antimicrobial agents for the preservation of cosmetics, pharmaceuticals and foods. Mostly used parabens are me...
Yang, Kailynn June Lee, Jennifer Park, Hannah Lui
BACKGROUND:Organophosphate pesticides (OPs) are one of the most commonly used classes of insecticides in the U.S., and metabolites of OPs have been detected in the urine of >75% of the U.S. POPULATION:While studies have shown that OP exposure is associated with risk of neurological diseases and some cancers, the relationship between OP exposure and...
Yang, Kailynn June Lee, Jennifer Park, Hannah Lui
Published in
International Journal of Environmental Research and Public Health
Background: Organophosphate pesticides (OPs) are one of the most commonly used classes of insecticides in the U.S., and metabolites of OPs have been detected in the urine of >75% of the U.S. population. While studies have shown that OP exposure is associated with risk of neurological diseases and some cancers, the relationship between OP exposure a...
