forner-piquer, isabel giommi, christian sella, fiorenza lombó, marta montik, nina valle, luisa dalla carnevali, oliana
The endocannabinoid system (ECS) is a lipid signaling system involved in numerous physiological processes, such as endocrine homeostasis, appetite control, energy balance, and metabolism. The ECS comprises endocannabinoids, their cognate receptors, and the enzymatic machinery that tightly regulates their levels within tissues. This system has been ...
Demaili, Arijana Portugalov, Anna Maroun, Mouna Akirav, Irit Braun, Katharina Bock, Jörg
Published in
Frontiers in Cellular Neuroscience
Several studies in both animal models and in humans have provided substantial evidence that early life stress (ELS) induces long-term changes in behavior and brain function, making it a significant risk factor in the aetiology of various mental disorders, including anxiety and depression. In this study, we tested the hypothesis that ELS in male rat...
Meccariello, Rosaria Aseer, Kanikkai Raja Kabir, Morvarid Santoro, Antonietta
Published in
Frontiers in Endocrinology
guardiola-ripoll, maria sotero-moreno, alejandro chaumette, boris kebir, oussama hostalet, noemí almodóvar-payá, carmen moreira, mónica giralt-lópez, maria krebs, marie-odile fatjó-vilas, mar
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Background: Dermatoglyphic pattern deviances have been associated with schizophrenia-spectrum disorders (SSD) and are considered neurodevelopment vulnerability markers based on the shared ectodermal origin of the epidermis and the central nervous system. The endocannabinoid system participates in epidermal differentiation, is sensitive to prenatal ...
martin-willett, renée skrzynski, carillon j. taylor, ethan m. sempio, cristina klawitter, jost bidwell, l. cinnamon
The public is increasingly reporting using cannabis for anxiety relief. Both cannabis use and the endocannabinoid system have been connected with anxiety relief/anxiolytic properties, but these relationships are complex, and the underlying mechanisms for them are unclear. Background/Objectives: Work is needed to understand how the endocannabinoid s...
Simei, João Luís Q Souza, José Diogo R Lisboa, João Roberto Campos, Alline C Guimarães, Francisco S Zuardi, Antonio Crippa, José Alexandre S
Published in
Cannabis and cannabinoid research
Background: The concept of an "entourage" effect in the cannabis and cannabinoids' field was first introduced in the late 1990s, during a period when most research on medical cannabinoids focused on the effects of isolated cannabinoids, such as cannabidiol and Δ9-tetrahydrocannabinol. Over the past decade, however, with the increased understanding ...
Hall, Stefan Faridi, Sufyan Trivedi, Purvi Castonguay, Mathieu Kelly, Melanie Zhou, Juan Lehmann, Christian
Published in
Cannabis and cannabinoid research
Background: The underlying pathomechanism of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is the immune response to inflammation or infection within the pulmonary microcirculation. Systemic spread of pathogens, activated immune cells, and inflammatory mediators contributes significantly to mortality in patients with ARDS. Obje...
Garcia-Luna, Guadalupe M Bermudes-Contreras, J David Hernández-Correa, Samantha Suarez-Ortiz, Josue O Diaz-Urbina, Daniel Garfias-Ramirez, Sergio H Vega, Ana V Villalobos-Molina, Rafael Vilches-Flores, Alonso
Published in
Cannabis and cannabinoid research
Background: The endocannabinoid system over-activation is associated with type-2 diabetes mellitus onset, involving physiological, metabolic, and genetic alterations in pancreatic islets. The use of Δ9-Tetrahydrocannabinol (THC) as treatment is still controversial since its effects and mechanisms on insulin secretion are unclear. The aim of this st...
brown, kevin funk, kyle barrientos, alexa figueroa bailey, ashly shrader, sarah feng, wenke mcclain, craig j. song, zhao-hui
Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that exists in the Cannabis sativa plant. CBD has been found to act on various receptors, including both cannabinoid and non-cannabinoid receptors. In addition, CBD has antioxidant effects that are independent of receptors. CBD has demonstrated modulatory effects at different organ syst...
lópez-tofiño, yolanda hopkins, mary a. bagues, ana boullon, laura abalo, raquel llorente-berzal, álvaro
Background/Objectives: Cisplatin, a common chemotherapy agent, is well known to cause severe side effects in the gastrointestinal and nervous systems due to its toxic and pro-inflammatory effects. Although pharmacological manipulation of the endocannabinoid system (ECS) can alleviate these side effects, how chemotherapy affects the ECS components i...