Thach, Bothidah Samarajeewa, Nirukshi Li, Ying Heng, Sophea Tsai, Tesha Pangestu, Mulyoto Catt, Sally Nie, Guiying
Published in
Biology of reproduction
Podocalyxin (PODXL) is a newly identified key negative regulator of human endometrial receptivity, specifically down-regulated in the luminal epithelium at receptivity to permit embryo implantation. Here, we bioinformatically compared the molecular characteristics of PODXL among the human, rhesus macaque, and mouse, determined by immunohistochemist...
shekibi;, manizha
Development of endometrial receptivity is crucial for successful embryo implantation and pregnancy initiation. Understanding the molecular regulation underpinning endometrial transformation to a receptive state is key to improving implantation rates in fertility treatments such as IVF. With microRNAs (miRNAs) increasingly recognized as important ge...
Bi, Yin Huang, Weiyu Yuan, Lifang Chen, Saiqiong Liao, Shengbin Fu, Xiaoqian Liu, Bo Yang, Yihua
Published in
Biology of reproduction
In the endometrium of women with recurrent implantation failure and unexplained recurrent miscarriage, the expression levels of homeobox A10 and E-cadherin were positively correlated. To explore whether homeobox A10 regulates E-cadherin during endometrial receptivity establishment, Ishikawa and RL95-2 cells were transfected with target-specific sma...
Tian, Qing He, Jia-Peng Zhu, Can Zhu, Qiu-Yang Li, Yu-Gu Liu, Ji-Long
Published in
Frontiers in Cell and Developmental Biology
Litter size is one of the most economically important traits in commercial pig farming. It has been estimated that approximately 30% of porcine embryos are lost during the peri-implantation period. Despite rapid advances over recent years, the molecular mechanism underlying embryo implantation in pigs remains poorly understood. In this study, the c...
chen;, xian
Current contraceptive methods interfere with folliculogenesis, fertilization, and embryo implantation by physical or hormonal approaches. Although hormonal contraceptive pills are effective in regulating egg formation, they are less effective in preventing embryo implantation. To explore the use of non-hormonal compounds that suppress embryo implan...
Dons'koi, Boris Onyshchuk, Oksana Kononenko, Iryna Sirenko, Vira Bodnar, Natalia Serbyn, Andrii Kozachok, Anzhela Brovarska, Yulia Osypchuk, Dariia Anochko, Yaroslava
...
Published in
Diagnostics (Basel, Switzerland)
Problem Many studies have demonstrated the negative impact of high rates of NK cytotoxicity (NKc) on reproductive processes, but there is no agreement as to the appropriateness and feasibility of using the NKc for routine diagnostic in IVF patients. This study conducted a retrospective analysis of embryo transfer (ET) success rates and live birth r...
pantos;, konstantinos
Recurrent implantation failure (RIF) is a multifactorial condition affecting 10–15% of in vitro fertilization (IVF) couples. Data suggest that functional dysregulation of the endometrial immune system constitutes one of the main pathophysiological mechanisms leading to RIF. The aim of this article is to provide a thorough presentation and evaluatio...
Aplin, John D Stevens, Adam
Published in
Human Reproduction (Oxford, England)
For some years, the prospect of precise and personalized timing of the endometrial cycle for optimal embryo replacement has been held out as a potential solution to low implantation rates. It is envisaged that a receptive state can be defined and reached at a predictable time, and embryo replacement performed in synchrony. In the last century, morp...
Ichikawa, Takafumi Zhang, Hui Ting Panavaite, Laura Erzberger, Anna Fabrèges, Dimitri Snajder, Rene Wolny, Adrian Korotkevich, Ekaterina Tsuchida-Straeten, Nobuko Hufnagel, Lars
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マウスの着床期の胚発生を三次元で再現することに成功. 京都大学プレスリリース. 2022-02-09. / A 3D culture model to study embryo growth. 京都大学プレスリリース. 2022-03-09. / Upon implantation, mammalian embryos undergo major morphogenesis and key developmental processes such as body axis specification and gastrulation. However, limited accessibility obscures the study of these crucial processes. H...
wei;, yiran
Exosomes are nano-sized vesicles with abundant nucleic acids, proteins, lipids, and other regulatory molecules. The aim of this study was to examine the effect of BOEC–Exo on bovine in vitro oocyte maturation and in vitro embryo development. We found that a 3% Exo supplementation to IVM media significantly enhanced the oocyte maturation and reduced...
