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Sundararajan, Vignesh Tan, Tuan Zea Lim, Diana Peng, Yanfen Wengner, Antje Margret Ngoi, Natalie Yan Li Jeyasekharan, Anand D Tan, David Shao Peng
Published in
The Journal of pathology
Excessive genomic instability coupled with abnormalities in DNA repair pathways induces high levels of 'replication stress' when cancer cells propagate. Rather than hampering cancer cell proliferation, novel treatment strategies are turning their attention towards targeting cell cycle checkpoint kinases (such as ATR, CHK1, WEE1, and others) along t...
Pal, Sharmistha Kaplan, Jakub P Nguyen, Huy Stopka, Sylwia A Savani, Milan R Regan, Michael S Nguyen, Quang-De Jones, Kristen L Moreau, Lisa A Peng, Jingyu
...
Published in
Cancer cell
Diffuse midline glioma (DMG) is a uniformly fatal pediatric cancer driven by oncohistones that do not readily lend themselves to drug development. To identify druggable targets for DMG, we conducted a genome-wide CRISPR screen that reveals a DMG selective dependency on the de novo pathway for pyrimidine biosynthesis. This metabolic vulnerability re...
