Background: Chronic (>4-weeks) cough in children is an important cause of morbidity. An algorithmic approach followed observational studies and a randomised controlled trial (RCT) enrolling children referred with median cough duration of 16-weeks to specialist centres. We determined if applying an evidence-based cough management algorithm earlier w...
Published in Biometrical Letters
The effective dose of six herbicidal ionic liquids containing glyphosate [N-(phosphonomethyl)glycine] was investigated. Varied biological activity of the tested compounds was observed depending on the type of cation and targeted plant species. In the case of common lambsquarters, the lowest effective dose was obtained for compounds containing didec...
Background Bronchiectasis guidelines recommend antibiotics for the treatment of acute respiratory exacerbations, but randomised placebo-controlled trials in children are lacking. We hypothesised that oral amoxicillin–clavulanate and azithromycin would each be superior to placebo in achieving symptom resolution of non-severe exacerbations in childre...
Published in Studia Geophysica et Geodaetica
Classical outlier detection test methods such as Baarda test and Pope test are generally preferred in geodetic problems. They depend on the Least Square Estimation (LSE) and LSE is very sensitive to the variations of the model. The capacity of the LSE changes depending on the different significance level, different type of outlier, the number of ou...
Abstract The production of blackberry in Colombia is a source of income and rural employment in 18 departments; however, the plant is affected by diseases such as gray mold, anthracnose and powdery mildew that can cause losses of up to 70%. The control of these diseases is mainly carried out with chemical fungicides such as benomyl, carbendazim and...
INTRODUCTION: Durvalumab is a selective, high-affinity human IgG1 monoclonal antibody that blocks programmed cell death ligand-1 (PD-L1) binding to PD-1. Here we report safety and clinical activity in the non-small cell lung cancer (NSCLC) cohort of a Phase 1/2 trial that included multiple tumor types (Study 1108; NCT01693562). METHODS: Patients wi...
Intravenous immunoglobulin (IVIG) is a potential therapy for chronic inflammatory demyelinating polyneuropathy (CIDP). To investigate the efficacy and safety of the IVIG IgPro10 (Privigen) for treatment of CIDP, results from Privigen Impact on Mobility and Autonomy (PRIMA), a prospective, open-label, single-arm study of IVIG in immunoglobulin (Ig)-...
Applying post-harvest control measures such as adding mycotoxin detoxifying agents is a frequently-used mitigation strategy for mycotoxins. EFSA states that the efficacy of these detoxifiers needs to be tested using specific biomarkers for exposure. However, the proposed biomarkers for exposure are not further optimized for specific target species....
Background: Biotic and abiotic factors have been reported to affect the larvicidal efficacy of Bacillus thuringiensis israelensis (Bti) and Bacillus sphaericus (Bs), although the extent to which they are affected has been poorly documented. This paper studies the effect of sunlight exposure on the efficacy of a new larvicide formulation based on bo...
College-aged individuals report having difficulty deciding what and how much information to provide to friends, yet they often turn to one another for information when experiencing relational uncertainty in a romantic relationship. Given the central role friendships have in college-aged individuals’ lives, identifying ways to decrease the difficult...
