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Blockade of Organic Anion Transport in Humans After Treatment With the Drug Probenecid Leads to Major Metabolic Alterati...

Published in Clinical pharmacology and therapeutics

Probenecid is used to treat gout and hyperuricemia as well as increase plasma levels of antiviral drugs and antibiotics. In vivo, probenecid mainly inhibits the renal SLC22 organic anion transporters OAT1 (SLC22A6), OAT3 (SLC22A8), and URAT1 (SLC22A12). To understand the endogenous role of these transporters in humans, we administered probenecid to...

A Biological Basis for Pharmacokinetics: The Remote Sensing and Signaling Theory.

Published in Clinical pharmacology and therapeutics

An Unsupervised Approach for Predicting Transporter-Mediated Drug-Metabolite Interactions

Organic anion transporter 1 (OAT1) and 3 (OAT3) are multi-specific renal drug transporters that facilitate the uptake and clearance of a wide range of endogenous and exogenous molecules. While they’ve been extensively studied for their clinical role in drug disposition and potential drug-drug interactions (DDIs), their physiological role in regulat...