Zhang, Sha Yan, Ming-Ming Zhao, Hui Qiu, Xiao-Yan Zhu, Deqiu
Published in
Frontiers in Pharmacology
Background Currently, there remains substantial controversy in research regarding whether the concomitant use of colchicine and statins increases the occurrence of rhabdomyolysis, warranting further substantiation. Objective This study aimed to identify the likelihood drug-drug interactions (DDIs) for the co-administration of colchicine and statins...
Peruzzi, Elena Posocco, Bianca Gerratana, Lorenzo Nuti, Margherita Orleni, Marco Gagno, Sara De Mattia, Elena Puglisi, Fabio Cecchin, Erika Toffoli, Giuseppe
...
Published in
Frontiers in Pharmacology
Palbociclib, an oral inhibitor of cyclin-dependent kinase 4 and 6, is approved for the treatment of metastatic breast cancer. This study investigated the influence of diverse clinical and biological factors—age, renal function, genetic variations, and concomitant medications (pharmacokinetic covariates)—on palbociclib pharmacokinetics. Employing a ...
Zhao, Fukun Luo, Min Wang, Yuanmin Su, Mu Tang, Fei
Published in
Frontiers in Pharmacology
Objective To detect muscular system adverse reaction signals of sacubitril/valsartan treatment combined with statins (atorvastatin, rosuvastatin, simvastatin) to provide a reference for clinical administration. Methods Multiplicative and additive models were used to mine the FDA’s spontaneous reports database to detect signals of drug-drug interact...
Kriner, Paul Brieger, Peter Pogarell, Oliver Schüle, Cornelius Mußmann, Lisa Korbmacher, Julie Seemüller, Florian
Published in
Frontiers in Psychiatry
Objectives Pharmacotherapy of bipolar depression (BPD) is confronted with major clinical challenges, like limited evidence-based treatment options, regular cases of treatment resistance, and risk of treatment-emergent affective switches. Medical guidelines can support practitioners to make decisions based on current scientific evidence. The objecti...
Hulin, Anne Gelé, Thibaut Fenioux, Charlotte Kempf, Emmanuelle Sahali, Dil Tournigand, Christophe Ollero, Mario
Published in
Clinical journal of the American Society of Nephrology : CJASN
Tyrosine kinase inhibitors (TKI) have introduced a significant advancement in cancer management. These compounds are administered orally, and their absorption holds a pivotal role in determining their variable efficacy. They exhibit extensive distribution within the body, binding strongly to both plasma and tissue proteins. Often reliant on efflux ...
Ren, Weifang Liu, Yujuan Jiang, Huaqiao Lv, Xiaoqun Zhang, Ning
Published in
Frontiers in Endocrinology
Background Combination therapy was associated with an increased risk of drug- drug interactions (DDIs) in patients with type 2 diabetes mellitus (T2DM). The present study aimed to investigate the epidemiology of potential DDIs (pDDIs), including potential chemical drug-drug interactions (pCDIs) and potential herb-drug interactions (pHDIs), and clas...
Bellanca, Carlo Maria Augello, Egle Di Benedetto, Giulia Burgaletto, Chiara Cantone, Anna Flavia Cantarella, Giuseppina Bernardini, Renato Polosa, Riccardo
Published in
Frontiers in Pharmacology
Currently 1.3 billion individuals globally engage in smoking, leading to significant morbidity and mortality, particularly among diabetic patients. There is urgent need for a better understanding of how smoking influences antidiabetic treatment efficacy. The review underscores the role of cigarette smoke, particularly polycyclic aromatic hydrocarbo...
Lin, Junpeng Hong, Binsheng Cai, Zhongqi Lu, Ping Lin, Kaibiao
Published in
Frontiers in Pharmacology
Accurately predicting Drug-Drug Interaction (DDI) is a critical and challenging aspect of the drug discovery process, particularly in preventing adverse reactions in patients undergoing combination therapy. However, current DDI prediction methods often overlook the interaction information between chemical substructures of drugs, focusing solely on ...
Miyake, Taiji Mochizuki, Tatsuki Nakagawa, Toshito Nakamura, Mikiko Emoto, Chie Komiyama, Natsuko Hirabayashi, Manabu Tsuruta, Satoshi Shimojo, Tomofumi Terao, Kimio
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Published in
British journal of pharmacology
Fraction metabolized (fm ) and fraction transported (ft ) are important for understanding drug-drug interactions (DDIs) in drug discovery and development. However, current in vitro systems cannot accurately estimate in vivo fm due to inability to reflect the ft by efflux transporters (ft,efflux ). This study demonstrates how CYP3A-mediated DDI for ...
Bustad, Ethan Mudrock, Emma Nilles, Elizabeth M. Mcquate, Andrea Bergado, Monica Gu, Alden Galitan, Louie Gleason, Natalie Ou, Henry C. Raible, David W.
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Published in
Frontiers in Pharmacology
Introduction: Ototoxicity is a debilitating side effect of over 150 medications with diverse mechanisms of action, many of which could be taken concurrently to treat multiple conditions. Approaches for preclinical evaluation of drug-drug interactions that might impact ototoxicity would facilitate design of safer multi-drug regimens and mitigate uns...
