Zheng, Lijun Xu, Yi Wang, Chen Guo, Liangsheng
Published in
Frontiers in Microbiology
Background The emergence of tolerance to antifungal agents in Candida albicans complicates the treatment of fungal infections. Understanding the mechanisms underlying this tolerance is crucial for developing effective therapeutic strategies. Objective This study aims to elucidate the genetic and molecular basis of ketoconazole tolerance in C. albic...
Li, Meng Li, Jing Zhang, Shiming Zhou, Linghan Zhu, Yuanyuan Li, Shen Li, Qiong Wang, Junjie Song, Ruipeng
Published in
Frontiers in Cell and Developmental Biology
Leukemia is a life-threatening malignant tumor of the hematopoietic system. Currently, the main treatment modalities are chemotherapy and hematopoietic stem cell transplantation. However, increased drug resistance due to decreased sensitivity of leukemia cells to chemotherapeutic drugs presents a major challenge in current treatments. Autophagy-ass...
Yang, Bo Vaisvil, Benjamin Schmitt, Daniel Collins, Joseph Young, Eric Kapatral, Vinayak Rao, Reeta
Published in
Infection and Immunity
Candida auris is an opportunistic fungal pathogen with high mortality rates which presents a clear threat to public health. The risk of C. auris infection is high because it can colonize the body, resist antifungal treatment, and evade the immune system. The genetic mechanisms for these traits are not well known. Identifying them could lead to new ...
Forsberg Olsson, Ellinor
Homogeneous bridging assays is a prevalent technique in bioanalytical research, utilizing capture anddetection proteins to identify and characterize the amount of specific analytes in biological samples.The classic bridging complex is in this study developed and new strategies with larger complexformation including DNP- and DIG-labeled drugs are in...
Sasse, Christoph Bastakis, Emmanouil Bakti, Fruzsina Höfer, Annalena M. Zangl, Isabella Schüller, Christoph Köhler, Anna M. Gerke, Jennifer Krappmann, Sven Finkernagel, Florian
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Published in
mBio
An overexpression screen of 228 zinc cluster transcription factor encoding genes of A. fumigatus revealed 11 genes conferring increased tolerance to antifungal drugs. Out of these, four oxidative stress and drug tolerance transcription factor encoding odr genes increased tolerance to oxidative stress and antifungal drugs when overexpressed. This su...
Padmapriyadarsini, Chandrasekaran Szumowski, John D. Akbar, Nabila Shanmugasundaram, Prema Jain, Anilkumar Bathragiri, Marasamy Pattnaik, Manoranjan Turuk, Jyotirmayee Karunaianantham, Ramesh Balakrishnan, Senthilkumar
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Published in
Clinical pharmacology and therapeutics
Induction of mycobacterial efflux pumps is a cause of Mycobacterium tuberculosis (Mtb) drug tolerance, a barrier to shortening antitubercular treatment. Verapamil inhibits Mtb efflux pumps that mediate tolerance to rifampin, a cornerstone of tuberculosis treatment. Verapamil’s mycobacterial efflux pump inhibition also limits Mtb growth in macrophag...
Chen, Biqing Zhao, Liping Yang, Rulin Xu, Tianmin
Published in
Frontiers in Genetics
Ovarian cancer affects the female reproductive system and is the primary cause of cancer related mortality globally. The imprecise and non-specific nature of ovarian cancer symptoms often results in patients being diagnosed at an advanced stage, with metastatic lesions extending beyond the ovary. This presents a significant clinical challenge and i...
Valderrama-Beltrán, Sandra Liliana Martínez-Vernaza, Samuel Correa-Forero, Shirley Vanessa Jaimes-Reyes, Maria Alejandra Arévalo-Mora, Leonardo Martínez-Buitrago, Ernesto Franco, Julieta Beltrán-Rodríguez, Claudia Urrego-Reyes, Juan Leon, Sebastian
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Published in
International journal of STD & AIDS
Long-term use of antiretroviral therapy (ART) for HIV infection might lead to the necessity of switching regimens. We aimed to analyze the reasons for the ART switch, the time-to-switch of ART, and its associated factors in a Colombian cohort. We conducted a retrospective cohort in 20 HIV clinics, including participants ≥18 years old with confirmed...
Jara, Marlene; Arevalo, Jorge; Llanos-Cuentas, Alejandro; Van den Broeck, Frederik; 69739; Domagalska, Malgorzata Anna; Dujardin, Jean-Claude;
status: published
Jara, Marlene Arevalo, Jorge Llanos-Cuentas, Alejandro Broeck, Frederik Van den Domagalska, Malgorzata Anna Dujardin, Jean-Claude
Published in
Frontiers in Cellular and Infection Microbiology
Introduction Resistance against anti-Leishmania drugs (DR) has been studied for years, giving important insights into long-term adaptations of these parasites to drugs, through genetic modifications. However, microorganisms can also survive lethal drug exposure by entering into temporary quiescence, a phenomenon called drug tolerance (DT), which is...
