Chang, Jae H Zhang, Xiaolin Messick, Kirsten Chen, Yi-Chen Chen, Eugene Cheong, Jonathan Ly, Justin
Published in
Xenobiotica; the fate of foreign compounds in biological systems
1. Oatp inhibitors have been shown to significantly increase the plasma exposure of statins. However, understanding alterations of liver concentration is also important. While modeling has simulated liver concentration changes, availability of experimental data is limited, especially when concerning drug-drug interactions (DDI). The objective of th...
Wagner, David J Duan, Haichuan Chapron, Alenka Lee, Richard W Wang, Joanne
Published in
Xenobiotica; the fate of foreign compounds in biological systems
1. Beta-carbolines are indole alkaloids with a wide range of pharmacological and toxicological activities. Beta-carbolines are structurally related to the neurotoxin 1-methyl-4-phenylpyridinium (MPP+), a known substrate of organic cation transporters (OCTs). The goal of this study is to determine the interaction of β-carbolines with human OCT1, 2, ...
Cao, Lei Kwara, Awewura Greenblatt, David J
Published in
The Journal of pharmacy and pharmacology
Inhibition of human CYP activity by luteolin and quercetin occurred with IC50 values exceeding customary in-vivo human exposure with tolerable supplemental doses of these compounds. The findings indicate that luteolin and quercetin are not likely to be of clinical value for preventing or treating APAP-induced hepatotoxicity.
Angiolillo, Dominick J Rollini, Fabiana Storey, Robert F Bhatt, Deepak L James, Stefan Schneider, David J Sibbing, Dirk So, Derek Y F Trenk, Dietmar Alexopoulos, Dimitrios
...
Published in
Circulation
Dual antiplatelet therapy with aspirin and a P2Y12 inhibitor is the treatment of choice for the prevention of atherothrombotic events in patients with acute coronary syndromes and for those undergoing percutaneous coronary interventions. The availability of different oral P2Y12 inhibitors (clopidogrel, prasugrel, ticagrelor) has enabled physicians ...
Tseng, Alice Hughes, Christine A Wu, Janet Seet, Jason Phillips, Elizabeth J
Published in
The Annals of pharmacotherapy
When assessing and managing potential interactions with ritonavir- or cobicistat-based regimens, clinicians need to be aware of important differences and distinctions between these agents. This is especially important for patients with multiple comorbidities and concomitant medications. Additional monitoring or medication dose adjustments may be ne...
Fassier, Philippine Egnell, Manon SROUR, Bernard VASSON, Marie-Paule Galan, Pilar Lécuyer, Lucie Latino Martel, Paule Hercberg, Serge Deschasaux, Mélanie Touvier, Mathilde
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Quantitative assessment of dietary supplement intake in 77 000 French adults: Impact on nutritional inadequacy, excessive intake, and extent of "at risk" practices. 21. International Congress of Nutrition (ICN)
Kropeit, Dirk von Richter, Oliver Stobernack, Hans-Peter Rübsamen-Schaeff, Helga Zimmermann, Holger
Published in
Clinical pharmacology in drug development
Letermovir is being developed for human cytomegalovirus infection treatment and prophylaxis. In patients receiving transplants, antivirals are coadministered with cyclosporine A (CsA) or tacrolimus (TAC) immunosuppressants. Therefore, we investigated the potential for letermovir-immunosuppressant interactions. In 2 phase 1 clinical trials either Cs...
Wagner, Christian Zhao, Ping Arya, Vikram Mullick, Charu Struble, Kimberly Au, Stanley
Published in
Journal of clinical pharmacology
Management of comorbidities and medications is complex in HIV-1-infected patients. The overall objective of this project was to develop separate physiologically based pharmacokinetic (PBPK) substrate models for the protease inhibitors darunavir and lopinavir. These protease inhibitors are used in the treatment of HIV infection. Both darunavir and l...
Smolders, Elise J Colbers, Angela de Kanter, Clara T M M Velthoven-Graafland, Kirsten Wolberink, Leonie T van Ewijk-Beneken Kolmer, Noor Drenth, Joost P H Aarnoutse, Rob E Tack, Cees J Burger, David M
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Published in
British journal of clinical pharmacology
Bioequivalence analysis showed that daclatasvir does not influence the pharmacokinetics of metformin in healthy subjects. Pharmacodynamic parameters were also comparable between treatments.
Gotlib, Dorothy Bostwick, Jolene R Calip, Seema Perelstein, Elizabeth Kurlander, Jacob E Fluent, Thomas
Published in
Psychopharmacology bulletin
This is a preliminary analysis that provides information about how psychiatry residents, attending physicians, and advanced practice nurse practitioners at our health system utilize a psychiatric pharmacist. This collaborative relationship may have implications for the future of psychiatric care delivery.
