Zand Irani, Anis Borchert, Grace Craven, Brendan Gibbons, Holly
Published in
BMJ case reports
A 75-year-old woman was admitted to a regional hospital with an acute kidney injury (AKI) and nausea on a background of recent treatment for Staphylococcus aureus bacteraemia secondary to pneumonia. The treatment thereof resulted in a high anion gap metabolic acidosis (HAGMA). The pneumonia was initially treated with intravenous piperacillin and ta...
Xu, Miao Zheng, Liang Zeng, Jin Xu, Wenwen Jiang, Xuehua Wang, Ling
Published in
Pharmacotherapy
The objective of this study was to establish physiologically based pharmacokinetic (PBPK) models of tramadol and its active metabolite O-desmethyltramadol (M1) and to explore the influence of CYP2D6 gene polymorphism on the pharmacokinetics of tramadol and M1. Furthermore, we used PBPK modeling to prospectively predict the extent of drug-drug inter...
Lima, Elisangela da Costa Camarinha, Barbara Dias Ferreira Bezerra, Nathalia Cristina Panisset, Anderson Gonçalves Belmino de Souza, Raquel Silva, Marcus Tolentino Lopes, Luciane Cruz
Published in
Frontiers in Pharmacology
Children are exposed to drug-drug interactions (DDI) risks due to their organism’s complexity and the need for several medicines prescriptions in pediatric intensive care units (PICU). This study aimed to assess the prevalence of potential DDIs in a Brazilian PICU. We carried out a cross-sectional study at a pediatric teaching hospital from Rio de ...
Spina, Edoardo Barbieri, Maria Antonietta Cicala, Giuseppe de Leon, Jose
Published in
Pharmaceuticals
This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or pharmacodynamic (PD) DIs. PubMed searches were conducted for each of the atypical antipsychotics a...
Huang, Kelly Cheng, Ching-Lan Yang, Yea-Huei Kao
Published in
Pharmacoepidemiology and drug safety
Magnesium stearate (MgSt) is a widely used excipient in pharmaceutical formulations but should be avoided in aspirin preparations as it hydrolyzes aspirin. We hypothesized that preparations of aspirin-containing MgSt (MgSt-ASA) are less effective in preventing thrombosis in clinical settings. The risk of composite cardiovascular events in patients ...
Marrs, Joel C Anderson, Sarah L
Published in
Drugs in Context
More than 422 million people worldwide have diabetes, with 90–95% having type 2 diabetes (T2D). Glycemic control of T2D has demonstrated reductions in microvascular complications but recent data have demonstrated improvements in macrovascular outcomes with sodium–glucose cotransporter 2 (SGLT2) inhibitors. Ertugliflozin is the most recent SGLT2 inh...
Chen, Luying Choi, Jaewoo Leonard, Scott W Banuvar, Suzanne Barengolts, Elena Viana, Marlos Chen, Shao-Nong Pauli, Guido F Bolton, Judy L van Breemen, Richard B
...
Published in
Journal of agricultural and food chemistry
Extracts of red clover (Trifolium pratense L.), containing estrogenic isoflavones like genistein and daidzein and the proestrogenic isoflavones formononetin and biochanin A, are used by women as dietary supplements for the management of menopausal symptoms. Although marketed as a safer alternative to hormone therapy, red clover isoflavones have bee...
Norz, Valentina Rausch, Steffen
Published in
Expert review of anticancer therapy
Introduction: The armamentarium of treatment options in metastatic and non-metastatic CRPC is rapidly evolving. However, the question of how individual treatment decisions should be balanced by available predictive clinical parameters, pharmacogenetic and drug interaction profiles, or compound-associated molecular biomarkers is a major challenge fo...
Tomczak, Szymon Stawny, Maciej Jelińska, Anna
Published in
Pharmaceutics
Parenteral nutrition (PN) admixtures are prone to interacting with drugs administered intravenously via a common catheter. This may cause a threat to a patient’s health and life. The literature that has been reported on the compatibility of loop diuretics with PN presents conflicting results. This work aimed to study the compatibility of furosemide...
Turnbull, Angus J Donaghy, Eddie Salisbury, Lisa Ramsay, Pamela Rattray, Janice Walsh, Timothy Lone, Nazir
Published in
British journal of anaesthesia
Polypharmacy is common and closely linked to drug interactions. The impact of polypharmacy has not been previously quantified in survivors of critical illness who have reduced resilience to stressors. Our aim was to identify factors associated with preadmission polypharmacy and ascertain whether polypharmacy is an independent risk factor for emerge...