Chao, Min-Wu Lin, Tony Eight HuangFu, Wei-Chun Chang, Chao-Di Tu, Huang-Ju Chen, Liang-Chieh Yen, Shih-Chung Sung, Tzu-Ying Huang, Wei-Jan Yang, Chia-Ron
...
Published in
Journal of enzyme inhibition and medicinal chemistry
The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 kinase pathway is linked with cancer malignancy. A small-molecule inhibitor targeting the STE20 kinase...
Li, Guangdi Xu, Ming Yue, Tingting Gu, Weijie Tan, Li
Published in
Biochemical Pharmacology
Since the 1950s, great efforts have been made to develop antiviral agents against many infectious diseases such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), human cytomegalovirus (HCMV), herpes simplex virus (HSV), and varicella-zoster virus (VZV). Among the list of nearly 106 antiviral agents approved in...
Fuerst, Rita Breinbauer, Rolf
Published in
Chembiochem : a European journal of chemical biology
Over the last two decades, activity-based protein profiling (ABPP) has been established as a tremendously useful proteomic tool for measuring the activity of proteins in their cellular context, annotating the function of uncharacterized proteins, and investigating the target profile of small-molecule inhibitors. Unlike hydrolases and other enzyme c...
Tomoshige, Shusuke Ishikawa, Minoru
Published in
Angewandte Chemie (International ed. in English)
Neurodegenerative disorders (NDs) are a group of diseases that cause neural cell damage, leading to motility and/or cognitive dysfunctions. One of the causative agents is misfolded protein aggregates, which are considered as undruggable in terms of conventional tools, such as inhibitors and agonists/antagonists. Indeed, there is currently no FDA-ap...
Roy, Sonam Khan, Shama Jairajpuri, Deeba Shamim Hussain, Afzal Alajmi, Mohamed F Islam, Asimul Luqman, Suaib Parvez, Suhel Hassan, Md Imtaiyaz
Published in
Journal of biomolecular structure & dynamics
Sphingosine kinase 1 (SphK1) and sphingosine-1-phosphate (S1P) signaling regulates numerous diseases such as cancer, diabetes, and inflammation-related ailments, rheumatoid arthritis, atherosclerosis, and multiple sclerosis. The importance of SphK1 in chemo-resistance has been extensively explored in breast, lung, colon, and hepatocellular carcinom...
Rybin, Matthew J. Ivan, Michael E. Ayad, Nagi G. Zeier, Zane
Published in
Frontiers in Cellular Neuroscience
Glioblastoma (GBM) is a devastating adult brain cancer with high rates of recurrence and treatment resistance. Cellular heterogeneity and extensive invasion of surrounding brain tissues are characteristic features of GBM that contribute to its intractability. Current GBM model systems do not recapitulate some of the complex features of GBM and have...
Haas, Paige Muralidharan, Monita Krogan, Nevan J Kaake, Robyn M Hüttenhain, Ruth
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), was declared a pandemic infection in March 2020. As of December 2020, two COVID-19 vaccines have been authorized for emergency use by the U.S. Food and Drug Administration, but there are no effective drugs to treat COV...
Mohammad, Taj Arif, Kaynat Alajmi, Mohamed F Hussain, Afzal Islam, Asimul Rehman, Md Tabish Hassan, Imtaiyaz
Published in
Journal of biomolecular structure & dynamics
Pyruvate dehydrogenase kinase 3 (PDK3) is a multifunctional enzyme that plays a central role in the cancer metabolic switch by blocking pyruvate catabolism in the TCA cycle. PDK3 plays a significant role in the TCA cycle and cancer cell progression, thus, considered as a novel drug target for developing effective therapeutics against varying types ...
Ibrahim, Sabrin R. M. Sirwi, Alaa Eid, Basma G. Mohamed, Shaimaa G. A. Mohamed, Gamal A.
Published in
Plants
Liver diseases represent a threat to human health and are a significant cause of mortality and morbidity worldwide. Autoimmune hepatitis (AIH) is a progressive and chronic hepatic inflammatory disease, which may lead to severe complications. Concanavalin A (Con A)-induced hepatic injury is regarded as an appropriate experimental model for investiga...
Singh, Archana Singh, Dheeraj K. Kharwar, Ravindra N. White, James F. Gond, Surendra K.
Published in
Microorganisms
Fungal endophytes are well-established sources of biologically active natural compounds with many producing pharmacologically valuable specific plant-derived products. This review details typical plant-derived medicinal compounds of several classes, including alkaloids, coumarins, flavonoids, glycosides, lignans, phenylpropanoids, quinones, saponin...
