Chao, Min-Wu Lin, Tony Eight HuangFu, Wei-Chun Chang, Chao-Di Tu, Huang-Ju Chen, Liang-Chieh Yen, Shih-Chung Sung, Tzu-Ying Huang, Wei-Jan Yang, Chia-Ron
...
Published in
Journal of enzyme inhibition and medicinal chemistry
The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 kinase pathway is linked with cancer malignancy. A small-molecule inhibitor targeting the STE20 kinase...
Ahmed, Sium Moni, Dil Afroj Sonawane, Kailas Dashrath Paek, Kee Yoeup Shohael, Abdullah Mohammad
Published in
Journal of biomolecular structure & dynamics
Eleutherococcus senticosus (Rupr. & Maxim.) Maxim., popularly known as 'Siberian ginseng', is an important medicinal plant. Pharmacologically active compounds of this plant are called eleutherosides and among them, eleutheroside B is the most prevalent. The E. senticosus has been reported to have many medicinal properties however; very few studies ...
Fatoki, Toluwase Hezekiah Ibraheem, Omodele Ogunyemi, Ibukun Oladejo Akinmoladun, Afolabi Clement Ugboko, Harriet U Adeseko, Catherine Joke Awofisayo, Oladoja A Olusegun, Sunday Joseph Enibukun, Jesupemi Mercy
Published in
Journal of biomolecular structure & dynamics
The novel coronavirus of 2019 (nCoV-19) has become a pandemic, affecting over 205 nations with over 7,410,000 confirmed cases which has resulted to over 418,000 deaths worldwide. This study aimed to identify potential therapeutic compounds and phytochemicals of medicinal plants that have potential to modulate the expression network of genes that ar...
Khan, Md Arif Mahmud, Shafi Alam, A S M Rubayet Ul Rahman, Md Ekhtiar Ahmed, Firoz Rahmatullah, Mohammed
Published in
Journal of biomolecular structure & dynamics
Recent outbreak of novel coronavirus and its rapid pandemic escalation in all over the world has drawn the attention to urgent need for effective drug development. However, due to prolonged vaccine and drug development procedure against a newly emerged devastating SARS-CoV-2 virus pathogen, repurposing of existing potential pertinent drug molecules...
Fiocchi, Claudio; Dragoni, Gabriele; Iliopoulos, Dimitrios; Katsanos, Konstantinos; Ramirez, Vicent Hernandez; Suzuki, Kohei; steering committee;, scientific workshop...
Many diseases that affect modern humans fall in the category of complex diseases, thus called because they result from a combination of multiple aetiological and pathogenic factors. Regardless of the organ or system affected, complex diseases present major challenges in diagnosis, classification, and management. Current forms of therapy are usually...
Fiocchi, Claudio Dragoni, Gabriele Iliopoulos, Dimitrios Katsanos, Konstantinos Ramirez, Vicent Hernandez Suzuki, Kohei
Published in
Journal of Crohn's & colitis
Many diseases that affect modern humans fall in the category of complex diseases, thus called because they result from a combination of multiple aetiological and pathogenic factors. Regardless of the organ or system affected, complex diseases present major challenges in diagnosis, classification, and management. Current forms of therapy are usually...
Panda, Sujogya Kumar Buroni, Silvia Tiwari, Vishvanath Nascimento da Silva, Luis Cláudio
Published in
Frontiers in Microbiology
salillas, sandra galano-frutos, juan josé mahía, alejandro maity, ritwik conde-giménez, maría anoz-carbonell, ernesto berlamont, helena velazquez-campoy, adrian touati, eliette mamat, uwe
...
Antimicrobial resistant (AMR) bacteria constitute a global health concern. Helicobacter pylori is a Gram-negative bacterium that infects about half of the human population and is a major cause of peptic ulcer disease and gastric cancer. Increasing resistance to triple and quadruple H. pylori eradication therapies poses great challenges and urges th...
Murail, Samuel de Vries, Sjoerd J. Rey, Julien Moroy, Gautier Tufféry, Pierre
Published in
Frontiers in Molecular Biosciences
In silico assessment of protein receptor interactions with small ligands is now part of the standard pipeline for drug discovery, and numerous tools and protocols have been developed for this purpose. With the SeamDock web server, we propose a new approach to facilitate access to small molecule docking for nonspecialists, including students. The Se...
Sharif, Najam A.
Published in
Frontiers in Pharmacology
Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual impairment and blindness in millions of people worldwide. The ocular hypertension (OHT) and the deleterious mechanical forces it exerts at the back of the eye, at the level of ...
