van Straalen, Kelsey R Tzellos, Thrasyvoulos Guillem, Phillipe Benhadou, Farida Cuenca-Barrales, Carlos Daxhelet, Mathilde Daoud, Mathieu Efthymiou, Ourania Giamarellos-Bourboulis, Evangelos J Jemec, Gregor B E
...
Published in
Journal of the American Academy of Dermatology
Tetracyclines and clindamycin plus rifampicin combination therapy are both considered first-line therapy in current hidradenitis suppurativa guidelines. However, evidence for their efficacy is drawn from small studies, often without validated outcomes. To assess the 12-week efficacy of oral tetracyclines and a combination of clindamycin and rifampi...
Alam, Safaet Kamal, Taslima Binte Sarker, Md. Moklesur Rahman Zhou, Jin-Rong Rahman, S. M. Abdur Mohamed, Isa Naina
Published in
Frontiers in Pharmacology
COVID-19, transmitted by SARS-CoV-2, is one of the most serious pandemic situations in the history of mankind, and has already infected a huge population across the globe. This horrendously contagious viral outbreak was first identified in China and within a very short time it affected the world's health, transport, economic, and academic sectors. ...
El Sayed, H Shalaby, S Abdel-Halim, M R E Aboelfadl, D M Samir, N
Published in
The Journal of dermatological treatment
Mycosis fungoides is the most common type of primary cutaneous T cell lymphomas. Doxycycline promoted apoptosis in different human malignant cell lines and in vivo models. To test for the therapeutic efficacy of doxycycline in comparison to PUVA in early stages of classic MF and its effect on T cell apoptosis. Thirty-six patients were randomized in...
Ta-Tang, Thuy-Huong Luz, Sergio L B Crainey, James L Rubio, José M
Published in
Research and Reports in Tropical Medicine
Mansonellosis is caused by three filarial parasite species from the genus Mansonella that commonly produce chronic human microfilaraemias: M. ozzardi, M. perstans and M. streptocerca . The disease is widespread in Africa, the Caribbean and South and Central America, and although it is typically asymptomatic it has been associated with mild patholog...
Aoki, Takahiro Mizushima, Daisuke Takano, Misao Ando, Naokatsu Uemura, Haruka Yanagawa, Yasuaki Watanabe, Koji Gatanaga, Hiroyuki Kikuchi, Yoshimi Oka, Shinichi
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Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Evidence on efficacy of high-dose ceftriaxone monotherapy for extragenital Neisseria gonorrhoeae (NG) infection is lacking. A cohort of men who have sex with men (MSM) were tested for NG/Chlamydia trachomatis (CT) every three months, in a single-center observational study in Tokyo, Japan. MSM aged > 19 years diagnosed with extragenital NG infection...
Mahmud, Reaz Rahman, Md Mujibur Alam, Iftikher Ahmed, Kazi Gias Uddin Kabir, A K M Humayon Sayeed, S K Jakaria Been Rassel, Mohammad Aftab Monayem, Farhana Binte Islam, Md Shahidul Islam, Mohammad Monirul
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Published in
The Journal of international medical research
We evaluated whether ivermectin combined with doxycycline reduced the clinical recovery time in adults with COVID-19 infection. This was a randomized, blinded, placebo-controlled trial in patients with mild-to-moderate COVID-19 symptoms randomly assigned to treatment (n = 200) and placebo (n = 200) groups. The primary outcome was duration from trea...
Paghdar, Smit Khan, Taheseen M Patel, Nishant P Chandrasekaran, Savitri De Sousa, Joaquim Francisco Maria Tsouklidis, Nicholas
Published in
Cureus
Abdominal aortic aneurysm (AAA) is a life-threatening condition associated with smoking, aging, atherosclerosis, and destruction of the connective tissue in the abdominal aortic wall. Disturbances in the synthesis and degradation of matrix metalloproteinase (MMP) have been known to contribute to the development of AAAs. The only available treatment...
Tuohutaerbieke, Maermaer Li, Xinjie Yin, Yue Chen, Wei Wu, Dongmei Mao, Zhize Mamuerjiang, Jiamixi Mao, Yimin Shen, Tao
Published in
Frontiers in Pharmacology
Background: We investigated the prevalence, demographic and clinical features, and risk factors associated with drug-induced liver injury (DILI) during the treatment of brucellosis inpatients in a retrospective study. Methods: We collected the clinical data of 782 brucellosis inpatients admitted at the Shawan County People’s Hospital, Xinjiang, fro...
Wang, Zhao Wang, Yanbai Yang, Huan Guo, Jiayu Wang, Zhenhai
Published in
Frontiers in Cellular and Infection Microbiology
Neurobrucellosis is a chronic complication of human brucellosis that is caused by the presence of Brucella spp in the central nervous system (CNS) and the inflammation play a key role on the pathogenesis. Doxycycline (Dox) is a widely used antibiotic that induces apoptosis of bacteria-infected cells. However, the mechanisms of Brucella inhibition o...
Kortela, Elisa Kanerva, Mari J Puustinen, Juha Hurme, Saija Airas, Laura Lauhio, Anneli Hohenthal, Ulla Jalava-Karvinen, Päivi Nieminen, Tuomas Finnilä, Taru
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Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Lyme neuroborreliosis (LNB) is often treated with intravenous ceftriaxone even if doxycycline is suggested to be noninferior to ceftriaxone. We evaluated the efficacy of oral doxycycline in comparison to ceftriaxone in the treatment of LNB. Patients with neurological symptoms suggestive of LNB without other obvious reasons were recruited. The inclu...
