Fan, Jiang-Peng Geng, Hui-Zhen Ji, Ya-Wei Jia, Tao Treweek, Jennifer B Li, An-An Zhou, Chun-Yi Gradinaru, Viviana Xiao, Cheng
Published in
Acta pharmacologica Sinica
The nigrostriatal dopaminergic (DA) system, which includes DA neurons in the ventral and dorsal tiers of the substantia nigra pars compacta (vSNc, dSNc) and DA terminals in the dorsal striatum, is critically implicated in motor control. Accumulating studies demonstrate that both the nigrostriatal DA system and motor function are impaired in aged su...
Li, Jie Xu, Sui
Published in
Experimental and therapeutic medicine
The flavonoid tilianin is derived from the leaves of Dracocephalum moldavica L. amiales and has been proven to serve a neuroprotective role in cerebral ischemia. Therefore, the aim of the present study was to determine whether tilianin could prevent oxidative stress and the apoptosis of dopaminergic neurons in Parkinson's disease (PD). The dopamine...
Rakovic, Aleksandar Voß, Dorothea Vulinovic, Franca Meier, Britta Hellberg, Ann-Katrin Nau, Carla Klein, Christine Leipold, Enrico
Published in
Frontiers in Cellular Neuroscience
Induced pluripotent stem cell (iPSC)-based generation of tyrosine hydroxylase-positive (TH+) dopaminergic neurons (DNs) is a powerful method for creating patient-specific in vitro models to elucidate mechanisms underlying Parkinson’s disease (PD) at the cellular and molecular level and to perform drug screening. However, currently available differe...
Huang, Maoxin Xu, Liang Liu, Jin Huang, Pei Tan, Yuyan Chen, Shengdi
Published in
Frontiers in Aging Neuroscience
Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized with dopaminergic neuron (DaN) loss within the substantia nigra (SN). Despite bulk studies focusing on intracellular mechanisms of PD inside DaNs, few studies have explored the pathogeneses outside DaNs, or between DaNs and other cells. Here, we set out to probe the imp...
Navarro, Gemma Rea, William Quiroz, César Moreno, Estefanía Gomez, Devan Wenthur, Cody J Casadó, Vicent Leggio, Lorenzo Hearing, Matthew C Ferré, Sergi
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but oligomerizes with GHS-R1a, exerting a complex modulatory role that depends on its relative expression. D1 dopamine receptor (D1R) and D5R constitute the two D1-like receptor su...
Beiki, Reyhaneh Khaghani, Mahsa Esmaeili, Fariba Dehghanian, Fariba
Published in
Frontiers in Cellular Neuroscience
The development of dopaminergic (DA) neurons is a very complex process, and a combination of extrinsic and intrinsic factors involves their differentiation. Transcription factor, Nurr1 plays an essential role in the differentiation and maintenance of midbrain DA neurons. Nurr1-based therapies may restore DA function in Parkinson's disease (PD) by r...
Zeng, Yiwei Chen, Yunhui Zhang, Su Ren, Huan Xia, Jialin Liu, Mengnan Shan, Baozhi Ren, Yulan
Published in
Frontiers in Pharmacology
Methamphetamine (METH), an amphetamine-type psychostimulant, is highly abused worldwide. Chronic abuse of METH causes neurodegenerative changes in central dopaminergic neurons with numerous neuropsychiatric consequences. Neuronal apoptosis plays a critical role in METH-induced neurotoxicity and may provide promising pharmacological targets for prev...
Carecho, Rafael Figueira, Inês Terrasso, Ana Paula Godinho-Pereira, Joana de Oliveira Sequeira, Catarina Pereira, Sofia Azeredo Milenkovic, Dragan Leist, Marcel Brito, Catarina Nunes Dos Santos, Cláudia
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Published in
Molecular nutrition & food research
Diets rich in (poly)phenols have been associated with positive effects on neurodegenerative disorders, such as Parkinson's disease (PD). Several low-molecular weight (poly)phenol metabolites (LMWPM) are found in the plasma after consumption of (poly)phenol-rich food. It is expected that LMWPM, upon reaching the brain, may have beneficial effects ag...
Conway, James A. Kramer, Edgar R.
Published in
Neural Regeneration Research
The neurotrophic signaling of glial cell line-derived neurotrophic factor (GDNF) with its canonical receptor, the receptor tyrosine kinase RET, coupled together with the GDNF family receptor alpha 1 is important for dopaminergic neuron survival and physiology in cell culture experiments and animal models. This prompted the idea to try GDNF/RET sign...
Zhang, Xue Wang, Jing Gao, Jin-Zhao Zhang, Xiao-Na Dou, Kai-Xin Shi, Wan-Da Xie, An-Mu
Published in
Neural regeneration research
Dysfunctional autophagy often occurs during the development of neurodegenerative diseases, such as Parkinson's disease, Huntington's disease, and Alzheimer's disease. The purinergic P2X4 receptor is an ATP-gated ion channel that is widely expressed in the microglia, astrocytes, and neurons of the central and peripheral nervous systems. P2X4R is inv...
