Street, Jonathan M. Bellomo, Tiffany R. Koritzinsky, Erik H. Kojima, Hiroshi Yuen, Peter S. T. Star, Robert A.
Published in
Critical Care Explorations
Objectives: The furosemide stress test measures the volume of urine produced after a furosemide challenge. Furosemide stress test has previously demonstrated sensitive and specific prediction of progression to Kidney Disease: Improving Global Outcomes guideline defined acute kidney injury stage III in the ICU. Furosemide is actively excreted into t...
Zaika, Oleg Tomilin, Viktor N Pochynyuk, Oleh
Published in
American journal of physiology. Renal physiology
Adenosine plays an important role in various aspects of kidney physiology, but the specific targets and mechanisms of actions are not completely understood. The collecting duct has the highest expression of adenosine receptors, particularly adenosine A1 receptors (A1Rs). Interstitial adenosine levels are greatly increased up to a micromolar range i...
Jobst-Schwan, Tilman Klämbt, Verena Tarsio, Maureen Heneghan, John F Majmundar, Amar J Shril, Shirlee Buerger, Florian Ottlewski, Isabel Shmukler, Boris E Topaloglu, Rezan
...
Published in
Kidney international
Distal renal tubular acidosis is a rare renal tubular disorder characterized by hyperchloremic metabolic acidosis and impaired urinary acidification. Mutations in three genes (ATP6V0A4, ATP6V1B1 and SLC4A1) constitute a monogenic causation in 58-70% of familial cases of distal renal tubular acidosis. Recently, mutations in FOXI1 have been identifie...
Gratreak, Brittany D K Swanson, Elizabeth A Lazelle, Rebecca A Jelen, Sabina K Hoenderop, Joost Bindels, René J Yang, Chao-Ling Ellison, David H
Published in
Physiological reports
Calcineurin inhibitors (CNIs) are immunosuppressive drugs used to prevent graft rejection after organ transplant. Common side effects include renal magnesium wasting and hypomagnesemia, which may contribute to new-onset diabetes mellitus, and hypercalciuria, which may contribute to post-transplant osteoporosis. Previous work suggested that CNIs red...
Ren, Jiafa Rudemiller, Nathan P. Wen, Yi Lu, Xiaohan Privratsky, Jamie R. Crowley, Steven D.
Published in
Kidney international
Wu, Peng Gao, Zhong-Xiuzi Zhang, Dan-Dan Su, Xiao-Tong Wang, Wen-Hui Lin, Dao-Hong
Published in
Journal of the American Society of Nephrology : JASN
The basolateral potassium channel in the distal convoluted tubule (DCT), comprising the inwardly rectifying potassium channel Kir4.1/Kir5.1 heterotetramer, plays a key role in mediating the effect of dietary potassium intake on the thiazide-sensitive NaCl cotransporter (NCC). The role of Kir5.1 (encoded by Kcnj16) in mediating effects of dietary po...
Kurstjens, Steef Smeets, Bart Overmars-Bos, Caro Dijkman, Henry B den Braanker, Dirk J W de Bel, Thomas Bindels, René J M Tack, Cees J J Hoenderop, Joost G J de Baaij, Jeroen H F
...
Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hypomagnesemia (blood Mg2+ concentration
Abdel Khalek, Waed Rafael, Chloé Loisel-Ferreira, Irmine Kouranti, Ilektra Clauser, Eric Hadchouel, Juliette Jeunemaitre, Xavier
Published in
Journal of the American Society of Nephrology : JASN
Mutations in four genes, WNK lysine deficient protein kinase 1 and 4 (WNK1 and WNK4), kelch like family member 3 (KLHL3), or Cullin 3 (CUL3), can result in familial hyperkalemic hypertension (FHHt), a rare Mendelian form of human arterial hypertension. Although all mutations result in an increased abundance of WNK1 or WNK4, all FHHt-causing CUL3 mu...
Ishizawa, Kenichi Wang, Qin Li, Jinping Xu, Ning Nemoto, Yoshikazu Morimoto, Chikayuki Fujii, Wataru Tamura, Yoshifuru Fujigaki, Yoshihide Tsukamoto, Kazuhisa
...
Published in
Journal of the American Society of Nephrology : JASN
Background Mechanisms underlying the frequent association between salt-sensitive hypertension and type 2 diabetes remain obscure. We previously found that protein kinase C (PKC) activation phosphorylates Kelch-like 3 (KLHL3), an E3 ubiquitin ligase component, at serine 433. We investigated whether impaired KLHL3 activity results in increased renal ...
Penton, David Moser, Sandra Wengi, Agnieszka Czogalla, Jan Rosenbaek, Lena Lindtoft Rigendinger, Fritz Faresse, Nourdine Martins, Joana R. Fenton, Robert A. Loffing-Cueni, Dominique
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Published in
Journal of the American Society of Nephrology : JASN
Background A number of cAMP-elevating hormones stimulate phosphorylation (and hence activity) of the NaCl cotransporter (NCC) in the distal convoluted tubule (DCT). Evidence suggests that protein phosphatase 1 (PP1) and other protein phosphatases modulate NCC phosphorylation, but little is known about PP1’s role and the mechanism regulating its fun...
