Iroh Tam, Py Arnold, S L M Barrett, L K Chen, C R Conrad, T M Douglas, E Gordon, M A Hebert, D Henrion, M Hermann, D
...
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
We evaluated the efficacy, pharmacokinetics (PK), and safety of clofazimine (CFZ) in patients living with human immunodeficiency virus (HIV) with cryptosporidiosis. We performed a randomized, double-blind, placebo-controlled study. Primary outcomes in part A were reduction in Cryptosporidium shedding, safety, and PK. Primary analysis was according ...
Liao, Wanqian Chen, Chongxiang Wen, Tianmeng Zhao, Qingyu
Published in
Journal of clinical gastroenterology
This meta-analysis aims to combine the latest research evidence to assess the effect of probiotics on preventing antibiotic-associated diarrhea (AAD) in adults. PubMed, Cochrane Library, EMBASE, and Web of Science were searched for randomized placebo-controlled trials on probiotics preventing AAD. A random or fixed effect model was used to combine ...
Nounkeu, Carole Debora Gruber, Kenneth J. Kamgno, Joseph Teta, Ismael Dharod, Jigna Morarji
Published in
Global Health Action
Background : Water represents the core of food-energy nexus and is vital for human survival. In developing countries, contaminated water and lack of basic water services undermine efforts to improve nutritional status and related health issues. In the rural areas of Central Africa, a majority of the population lacks access to improved water sources...
Saviano, Angela Brigida, Mattia Migneco, Alessio Gunawardena, Gayani Zanza, Christian Candelli, Marcello Franceschi, Francesco Ojetti, Veronica
Published in
Medicina (Kaunas, Lithuania)
Background and Objectives: Lactobacillus reuteri DSM 17938 (L. reuteri) is a probiotic that can colonize different human body sites, including primarily the gastrointestinal tract, but also the urinary tract, the skin, and breast milk. Literature data showed that the administration of L. reuteri can be beneficial to human health. The aim of this re...
Sahiledengle, Biniyam Agho, Kingsley
Published in
Environmental Health Insights
Background: Determinants of childhood diarrhea in households with improved WASH (ie, households with improved drinking water sources, improved sanitation facilities, and those who practiced safe child stool disposal) are limited. This study aimed to identify the determinants of diarrhea among under-five children exclusively in households with impro...
Zhao, Ye Li, Xuewei Zhou, Yujing Gao, Jin Jiao, Yang Zhu, Baoli Wu, Depei Qi, Xiaofei
Published in
Frontiers in Immunology
Gastrointestinal (GI) tract graft-versus-host disease (GvHD) is a major cause of post-allo-HSCT (hematopoietic stem cell transplantation) morbidity and mortality. Patients with steroid-refractory GI-GvHD have a poor prognosis and limited therapeutic options. FMT2017002 trial (#NCT03148743) was a non-randomized, open-label, phase I/II clinical study...
Ma, Xin Zhang, Yuchen Xu, Tingting Qian, Mengqi Yang, Zhiren Zhan, Xiuan Han, Xinyan
Published in
Frontiers in Microbiology
Fecal microbiota transplantation (FMT) could shape the structure of intestinal microbiota in animals. This study was conducted to explore the changes that happen in the structure and function of microbiota caused by weaning stress, and whether early-life FMT could alleviate weaning stress through modifying intestinal microbiota in weaned piglets. D...
Chandwe, Kanta Kelly, Paul
Published in
Nutrients
There is increasing awareness that a broad range of gastrointestinal diseases, and some systemic diseases, are characterized by failure of the mucosal barrier. Bovine colostrum is a complex biological fluid replete with growth factors, nutrients, hormones, and paracrine factors which have a range of properties likely to contribute to mucosal healin...
Selimoglu, Mukadder Ayse Kansu, Aydan Aydogdu, Sema Sarioglu, Aysugul Alptekin Erdogan, Simge Dalgic, Buket Yuce, Aysel Cullu Cokugras, Fugen
Published in
Frontiers in Pediatrics
This review focuses on nutritional support in malnourished children with compromised gastrointestinal function addressing the interplay between malnutrition and gastrointestinal dysfunction, and the specific role of peptide-based enteral therapy in pediatric malnutrition. Malnutrition is associated with impaired gut functions such as increased inte...
Kelly, Paul
Published in
Advances in nutrition (Bethesda, Md.)
There is growing awareness that intestinal dysfunction determines the clinical outcomes of situations as diverse as undernourished children in urban tropical slums and undernourished surgical patients in intensive care units. As experimental starvation in humans has only rarely been studied, and largely not using current biomedical research tools, ...
