L’urbanisme partage avec d’autres disciplines, aussi éloignées que le droit et la médecine, une normativité évidente. Cependant, cette particularité, si elle est assumée par ces derniers domaines, l’est beaucoup plus difficilement par l’urbanisme qui, lorsqu’il n’est pas remis en cause comme discipline, semble se partager entre les énonciations qui...
Dans les dispositifs de formation professionnelle initiale en alternance, la question de ce qu’apportent respectivement la théorie et la pratique se poursuit, bien que soit connu depuis longtemps l’aspect pratique des théories, et la dimension conceptuelle de nombreuses pratiques. C’est à un même défi que Dewey nous confronte, en abolissant le dual...
Published in Experimental biology and medicine (Maywood, N.J.)
While the term 'biomarker' is relatively new, the concept is millennia old. However, with the introduction of new technologies to discover potential biomarkers comes the need to assess their utility and veracity for any given use. This is particularly true for the use of biomarkers to support regulatory decisions in medical product development. Hen...
Published in ACS nano
Extracellular vesicles (EV) are a family of cell-originating, membrane-enveloped nanoparticles with diverse biological function, diagnostic potential, and therapeutic applications. While EV can be abundant in circulation, their small size (∼4 order of magnitude smaller than cells) has necessitated bulk analyses, making many more nuanced biological ...
À partir d’une clinique de consultation thérapeutique parents-enfant en CMPP, cet article aborde les processus psychiques mobilisés, ou mis en sommeil, par l’exercice de la parentalité de petits enfants souffrant de handicaps psychiques. Le vécu de cette parentalité, si loin de celle idéalisée, confronte le parent à un éprouvé traumatique fréquemme...
Published in Human mutation
Ovarian cancer patients with germline or somatic pathogenic variants benefit from treatment with PARP inhibitors. Tumour BRCA1/2 testing is more challenging than germline testing as the majority of samples are formalin fixed paraffin embedded (FFPE), the tumour genome is complex and the allelic fraction of somatic variants can be low. We collaborat...
Published in Kidney international
Inherited kidney disease encompasses a broad range of disorders, with both multiple genes contributing to specific phenotypes and single gene defects having multiple clinical presentations. Advances in sequencing capacity may allow a genetic diagnosis for familial renal disease, by testing the increasing number of known causative genes. However, th...
Published in Journal of Interdisciplinary Medicine
Tinea incognito defines a modified clinical aspect of a tinea following an immunosuppressive therapy, mostly with potent topical steroids. Its diagnosis may be delayed by its delusive appearance, especially in small children and young adults. We present a series of 2 cases of Tinea incognito developed at different ages and incorrectly diagnosed ini...
This paper aims to investigate a frame for defining a first functional architecture of IEDS (Intelligent Embedded Diagnosis System) in the context of FDIR (Fault Detection, Isolation and Reconfiguration) and predictive maintenance. The IEDS has to be implemented on a system/component to be monitored/maintained (on board part) and should possess a l...
