Fink, Herbert Maihöfer, Tim Bender, Jeffrey Schulat, Jochen
Published in
Journal of Breath Research
Blood glucose monitoring (BGM) is the most important part of diabetes management. In classical BGM, glucose measurement by test strips involves invasive finger pricking. We present results of a clinical study that focused on a non-invasive approach based on volatile organic compounds (VOCs) in exhaled breath. Main objective was the discovery of mar...
Mirzadeh, Zaman Faber, Chelsea L. Schwartz, Michael W.
Historically, pancreatic islet beta cells have been viewed as principal regulators of glycemia, with type 2 diabetes (T2D) resulting when insulin secretion fails to compensate for peripheral tissue insulin resistance. However, glycemia is also regulated by insulin-independent mechanisms that are dysregulated in T2D. Based on evidence supporting its...
Govindsamy, Annelene Ghoor, Samira Cerf, Marlon E.
Published in
Frontiers in Endocrinology
Fetal programming refers to an intrauterine stimulus or insult that shapes growth, development and health outcomes. Dependent on the quality and quantity, dietary fats can be beneficial or detrimental for the growth of the fetus and can alter insulin signaling by regulating the expression of key factors. The effects of varying dietary fat content o...
Yang, Ying Shu, Hua Hu, Jingxin Li, Lei Wang, Jianyu Chen, Tingting Zhen, Jinyang Sun, Jinhong Feng, Wenli Xiong, Yi
...
Published in
Frontiers in Endocrinology
Preproinsulin (PPI) translocation across the membrane of the endoplasmic reticulum (ER) is the first and critical step of insulin biosynthesis. Inefficient PPI translocation caused by signal peptide (SP) mutations can lead to β-cell failure and diabetes. However, the effect of proinsulin domain on the efficiency of PPI translocation remains unknown...
Ren, Meng Lin, Diao zhu Liu, Zhi Peng Sun, Kan Wang, Chuan Lao, Guo juan Fan, Yan qun Wang, Xiao yi Liu, Jing Du, Jie
...
Published in
Frontiers in Endocrinology
Background Identifying the metabolite profile of individuals with prediabetes who turned to type 2 diabetes (T2D) may give novel insights into early T2D interception. The purpose of this study was to identify metabolic markers that predict the development of T2D from prediabetes in a Chinese population. Methods We used an untargeted metabolomics ap...
Wolf, Victoria Abdul, Yasir Ergul, Adviye
Published in
Frontiers in Physiology
Diabetes and cognitive dysfunction, ranging from mild cognitive impairment to dementia, often coexist in individuals over 65 years of age. Vascular contributions to cognitive impairment/dementia (VCID) are the second leading cause of dementias under the umbrella of Alzheimer’s disease and related dementias (ADRD). Over half of dementia patients hav...
Bai, Yi-ling Han, Ling-ling Qian, Jun-hui Wang, Hao-zhong
Published in
Frontiers in Pharmacology
Puerarin is a predominant component of Radix Puerarin. Despite its anti-tumor and anti-virus effects and efficacy in improving cardiovascular or cerebrovascular diseases and preventing osteoporosis, it has been shown to protect against diabetes and its complications. This review summarizes the current knowledge on Puerarin in diabetes and related c...
He, Yan Zhu, Hanyun Zhang, Min Li, Jing Ma, Shengqi Lu, Yin Chen, Linan Zhang, Mingzhi Peng, Hao
Published in
Frontiers in Endocrinology
Background Furin has been associated with glucose metabolic phenotypes in small sampled clinical studies. However, this association has not yet been studied in Chinese. Here, we aimed to examine the association between serum furin and fasting glucose in Chinese adults. Methods Serum furin and fasting plasma glucose were assayed for 2,172 participan...
Zammouri, Jamila Vatier, Camille Capel, Emilie Auclair, Martine Storey-London, Caroline Bismuth, Elise Mosbah, Héléna Donadille, Bruno Janmaat, Sonja Fève, Bruno
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Published in
Frontiers in Endocrinology
Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired causes, but leads to similar metabolic complications with insulin resistance, diabetes, hypertriglyceridemia, nonalcoholic fatty liver disease, dysfunctions of the gona...
Cavalcanti, Deborah Bujold, Emmanuel
Published in
Frontiers in Endocrinology
