Cernescu, Luminita Daniela Haidar, Laura Panaitescu, Carmen
Published in
Experimental and therapeutic medicine
Allergic asthma is a chronic airway inflammatory disorder triggered by inhalant allergens. Interleukin (IL)-4 and IL-13 play a main role in the generation of T helper cell type 2 (Th2) immune response, induction of immunoglobulin E (IgE) synthesis and persistence of airway inflammation. The aim of the present study was to investigate the influence ...
Jarc, Daša
Marshall, Payton L Nagy, Nadine Kaber, Gernot Barlow, Graham L Ramesh, Amrit Xie, Bryan J Linde, Miles H Haddock, Naomi L Lester, Colin A Tran, Quynh-Lam
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Published in
Matrix biology : journal of the International Society for Matrix Biology
A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabilizes interactions between DC and T-cells, and prev...
Scheenstra, Maaike R Martínez-Botía, Patricia Acebes-Huerta, Andrea Brouwer, Rutger W W Caballero-Sánchez, Noemí Gillemans, Nynke De Bleser, Pieter Nota, Benjamin De Cuyper, Iris M Salunkhe, Vishal
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Published in
Journal of leukocyte biology
Dendritic cells (DCs) are key immune modulators and are able to mount immune responses or tolerance. DC differentiation and activation imply a plethora of molecular and cellular responses, including transcriptional changes. PU.1 is a highly expressed transcription factor in DCs and coordinates relevant aspects of DC biology. Due to their role as im...
Bucşan, Allison N Williamson, Kim C
Published in
Virulence
Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, nor the role of continual parasite exposure have bee...
Feng, Haibo Yang, Xiaonong Fan, Jing Zhang, Linzi Liu, Qianqian Chai, Dongkun
Published in
Drug delivery
DEC-205 receptor-mediated dendritic cells (DC) targeting nanoliposomes is a promising delivery system in eliciting an immune response against pathogens. When this delivery system carries both antigen and immunomodulator, it can effectively regulate the DC function as well as the initial T cell response. To maximize the desired therapeutic effects o...
Lutckii, Anton Strunz, Benedikt Zhirkov, Anton Filipovich, Olga Rukoiatkina, Elena Gusev, Denis Lobzin, Yuriy Fischler, Björn Aleman, Soo Sällberg, Matti
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Published in
Gut
Vertical transmission of hepatitis C virus (HCV) is rare compared with other chronic viral infections, despite that newborns have an immature, and possibly more susceptible, immune system. It further remains unclear to what extent prenatal and perinatal exposure to HCV affects immune system development in neonates. To address this, we studied B cel...
Papadas, Athanasios Arauz, Garrett Cicala, Alexander Wiesner, Joshua Asimakopoulos, Fotis
Published in
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer development, ranging from proliferative signaling, evasion of growth-suppressor pathways, regulation of cell death, promotion of neoangiogenesis, and tissue invasion and metastasis. Multiple lines of evidence implicate versican and its bioactive proteolytic...
Lai, Jen-Feng Thompson, Lucas J Ziegler, Steven F
Published in
The Journal of allergy and clinical immunology
Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine that is important for the development of type 2 inflammatory responses at mucosal surfaces. In humans, TSLP level has been found to be elevated in the lungs of patients with asthma, and in mouse models, TSLP can promote type 2 airway inflammation, primarily through the activation...
Liberal, Ângela Fernandes, Ângela Polyzos, Nikolaos Petropoulos, Spyridon A Dias, Maria Inês Pinela, José Petrović, Jovana Soković, Marina Ferreira, Isabel C F R Barros, Lillian
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Published in
Molecules (Basel, Switzerland)
Petroselinum crispum Mill., Fuss., is a culinary vegetable used as an aromatic herb that garnishes and flavours a great variety of dishes. In the present study, the chemical profiles and bioactivities of leaf samples from 25 cultivars (three types: plain- and curly-leafed and turnip-rooted) from this species were assessed. Seven phenolic compounds ...
