Ganzleben, Ingo Geppert, Carol Osaba, Lourdes Hirschmann, Simon Nägel, Andreas Glück, Christian Hoffman, Arthur Rath, Timo Nagore, Daniel Neurath, Markus F.
...
Published in
Therapeutic Advances in Gastroenterology
The therapeutic management of patients with severe steroid-refractory ulcerative colitis still represents a critical clinical challenge. In this setting, cyclosporin is an effective and rapidly acting induction treatment that is applied in combination with maintenance therapeutic agents like thiopurines or vedolizumab. Here, we present the case of ...
Gérard, Alexandre Romani, Serena Van-Obberghen, Elise Fresse, Audrey Muzzone, Marine Parassol, Nadège Boscagli, Annick Rocher, Fanny Borchiellini, Delphine Drici, Milou-Daniel
...
Published in
Frontiers in Oncology
Anemia associated with Immune checkpoint inhibitor (ICI) is usually hemolytic and regenerative. Cases of non-regenerative pure red cell aplasia are rare, and typically improve upon drug discontinuation and after corticotherapy. We herein report a case of nivolumab-related erythroblastopenia refractory to steroids in a melanoma patient that improved...
Beksac, M Sinan Fadiloglu, Erdem Cakar, Ayse Nur Gurbuz, Rumeysa Hekimoglu Atilla, Pergin Onbasilar, Ilyas Beksac, Kemal Katlan, Doruk Cevdi Mumusoglu, Sezcan Calis, Pinar
...
Published in
Fetal and pediatric pathology
Objective: To compare fetal cell microchimerism in normal and immunocompromised gestations. Materials and methods: The study consists of two groups of mature female mice. In the control group and the immunocompromised study group, 5 mg of saline and cyclosporine were injected intraperitoneally, respectively. In the second step, all female mice were...
Elens, Laure Langman, Loralie J. Hesselink, Dennis A. Bergan, Stein Moes, Dirk Jan A.R. Molinaro, Mariadelfina Venkataramanan, Raman Lemaitre, Florian
Published in
Therapeutic Drug Monitoring
COVID-19 is a novel infectious disease caused by the severe acute respiratory distress (SARS)-coronavirus-2 (SARS-CoV-2). Several therapeutic options are currently emerging but none with universal consensus or proven efficacy. Solid organ transplant recipients are perceived to be at increased risk of severe COVID-19 because of their immunosuppresse...
Nebbioso, Marcella Alisi, Ludovico Giovannetti, Francesca Armentano, Marta Lambiase, Alessandro
Published in
Clinical Ophthalmology (Auckland, N.Z.)
Vernal keratoconjunctivitis (VKC) is a rare, recurrent and multifactorial ocular disease, which typically flares up during spring and affects especially male children and adolescents. This condition does not usually respond to common treatments with antihistamines or mast cells stabilizers, whereas corticosteroids have effective results. Corticoste...
Back, Hyun-moon Lee, Jong Bong Han, Nayoung Goo, Sungwoo Jung, Eben Kim, Junyeong Song, Byungjeong An, Sook Hee Kim, Jung Tae Rhie, Sandy Jeong
...
Published in
Pharmaceutics
Traditionally, dosage for pediatric patients has been optimized using simple weight-scaled methods, but these methods do not always meet the requirements of children. To overcome this discrepancy, population pharmacokinetic (PK) modeling of size and maturation functions has been proposed. The main objective of the present study was to evaluate a ne...
Sallustio, Benedetta C Noll, Benjamin D Coller, Janet K Tuke, Jonathan Russ, Graeme Somogyi, Andrew A
Published in
British journal of clinical pharmacology
The immunosuppressant cyclosporin is a P-glycoprotein (P-gp) substrate whose impaired function has been associated with an increased risk of cyclosporin-induced nephrotoxicity following renal transplantation. This study investigated the relationship between blood and allograft cyclosporin concentration, and the effect of P-gp expression. Fifty biop...
Fedotcheva, T. A. Sheichenko, O. P. Sheichenko, V. I. Fedotcheva, N. I. Shimanovskii, N. L.
Published in
Pharmaceutical Chemistry Journal
Escin-containing horse chestnut extracts and various medicinal formulations are widely used as venotonic agents whose mechanisms of action and intracellular targets remain unknown. Escin is used as an active substance to increase membrane permeability in experiments, and it has more recently been shown to have cytotoxic effects on a number of tumor...
Wang, Dongdong Chen, Xiao Li, Zhiping
Published in
Experimental and Therapeutic Medicine
Different models of population pharmacokinetics (PPK) of cyclosporin have been established in various populations. However, the cyclosporin PPK model in patients with pediatric refractory nephrotic syndrome (PRNS) has yet to be constructed. The present study aimed to establish the cyclosporin PPK model in PRNS, and to identify factors that may acco...
Han, Xuechao Xu, Jingman Xu, Sen Sun, Yahan He, Mali Li, Xiaodong Li, Xinyu Pi, Jiayi Yu, Rui Tian, Wei
...
Published in
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
To explore the role of mitochondrial permeability transition pore (mPTP) in mediating the protective effect of gastrodin against oxidative stress damage in H9c2 cardiac myocytes. H9c2 cardiac myocytes were treated with H2O2, gastrodin, gastrodin+H2O2, cyclosporin A (CsA), or CsA+gas+H2O2 group. MTT assay was used to detect the survival ratio of H9c...
