Elens, Laure Langman, Loralie J. Hesselink, Dennis A. Bergan, Stein Moes, Dirk Jan A.R. Molinaro, Mariadelfina Venkataramanan, Raman Lemaitre, Florian
Published in
Therapeutic Drug Monitoring
COVID-19 is a novel infectious disease caused by the severe acute respiratory distress (SARS)-coronavirus-2 (SARS-CoV-2). Several therapeutic options are currently emerging but none with universal consensus or proven efficacy. Solid organ transplant recipients are perceived to be at increased risk of severe COVID-19 because of their immunosuppresse...
Nebbioso, Marcella Alisi, Ludovico Giovannetti, Francesca Armentano, Marta Lambiase, Alessandro
Published in
Clinical Ophthalmology (Auckland, N.Z.)
Vernal keratoconjunctivitis (VKC) is a rare, recurrent and multifactorial ocular disease, which typically flares up during spring and affects especially male children and adolescents. This condition does not usually respond to common treatments with antihistamines or mast cells stabilizers, whereas corticosteroids have effective results. Corticoste...
Back, Hyun-moon Lee, Jong Bong Han, Nayoung Goo, Sungwoo Jung, Eben Kim, Junyeong Song, Byungjeong An, Sook Hee Kim, Jung Tae Rhie, Sandy Jeong
...
Published in
Pharmaceutics
Traditionally, dosage for pediatric patients has been optimized using simple weight-scaled methods, but these methods do not always meet the requirements of children. To overcome this discrepancy, population pharmacokinetic (PK) modeling of size and maturation functions has been proposed. The main objective of the present study was to evaluate a ne...
Sallustio, Benedetta C Noll, Benjamin D Coller, Janet K Tuke, Jonathan Russ, Graeme Somogyi, Andrew A
Published in
British journal of clinical pharmacology
The immunosuppressant cyclosporin is a P-glycoprotein (P-gp) substrate whose impaired function has been associated with an increased risk of cyclosporin-induced nephrotoxicity following renal transplantation. This study investigated the relationship between blood and allograft cyclosporin concentration, and the effect of P-gp expression. Fifty biop...
Fedotcheva, T. A. Sheichenko, O. P. Sheichenko, V. I. Fedotcheva, N. I. Shimanovskii, N. L.
Published in
Pharmaceutical Chemistry Journal
Escin-containing horse chestnut extracts and various medicinal formulations are widely used as venotonic agents whose mechanisms of action and intracellular targets remain unknown. Escin is used as an active substance to increase membrane permeability in experiments, and it has more recently been shown to have cytotoxic effects on a number of tumor...
Wang, Dongdong Chen, Xiao Li, Zhiping
Published in
Experimental and Therapeutic Medicine
Different models of population pharmacokinetics (PPK) of cyclosporin have been established in various populations. However, the cyclosporin PPK model in patients with pediatric refractory nephrotic syndrome (PRNS) has yet to be constructed. The present study aimed to establish the cyclosporin PPK model in PRNS, and to identify factors that may acco...
HAN, Xuechao XU, Jingman XU, Sen SUN, Yahan HE, Mali LI, Xiaodong LI, Xinyu PI, Jiayi YU, Rui TIAN, Wei
...
Published in
Journal of Southern Medical University
目的 探讨H9c2心肌细胞发生氧化应激损伤时，线粒体膜上的线粒体通透性转换孔（mPTP）在天麻素抗氧化应激损伤的保护机制中所发挥的作用。 方法 本实验分为6组：正常组，过氧化氢组，天麻素+过氧化氢组，天麻素组，环孢菌素A组，环孢菌素A+天麻素+过氧化氢组。通过加入环孢菌素A（mPTP开放剂）观察天麻素的保护作用是否被抑制。用MTT法初步检测各组细胞存活率，采用Annexin V-FITC/PI双染法通过流式细胞仪观察细胞早期凋亡率，大鼠三磷酸腺苷（ATP）试剂盒检测ATP的含量，活性氧检测试剂盒检测细胞内活性氧（ROS）的含量，激光扫描共聚焦显微镜观察Jc-1标记的线粒体膜电位，Western blot检测细胞内细胞色素C（Cyt C）含量，Caspase-3活性检测试剂盒检测caspase...
Bibb, Lorin A Winter, Randi P Leicht, Stuart S
Published in
Cureus
Erythromelalgia is a neurovascular disorder which causes pain, swelling, erythema, and warmth of the distal extremities. Primary disease is due to a genetic mutation in the SCN9A gene, but secondary erythromelalgia can be the consequence of a variety of underlying etiologies, including drug and toxin exposures. The disease is rare, occurring in onl...
Khurana, Harshit Malhotra, Pankaj Sachdeva, Man Updesh Varma, Neelam Bose, Parveen Yanamandra, Uday Varma, Subhash Khadwal, Alka Lad, Deepesh Prakash, Gaurav
...
Published in
Hematology (Amsterdam, Netherlands)
Danazol is an attenuated androgen and is used in the treatment of aplastic anemia (AA) in resource constraint settings. We chose to study the role of CD4+ CD25high CD127low FoxP3+ T regulatory cells (T-regs) in the pathophysiology of AA and their response to treatment with Danazol alone or in combination with immunosuppressive treatment (IST). T-re...
Deng, Wei Miao, Chaoyang Zhang, Xiaoyan
Published in
The Journal of dermatology
We report a case of a 30-year-old Chinese woman with rheumatoid arthritis and interstitial lung disease who abruptly developed generalized pustules and a high fever for 10 days. She had been taking oral prednisone, iguratimod and total glucosides of peony regularly for 5 months prior. In addition, she had taken metronidazole for 3 days 20 days prio...
