Published in The Biochemical journal
Transmission blocking interventions can stop malaria parasite transmission from mosquito to human by inhibiting parasite infection in mosquitos. One of the most advanced candidates for a malaria transmission blocking vaccine is Pfs230. Pfs230 is the largest member of the 6-cysteine protein family with 14 consecutive 6-cysteine domains and is expres...
Published in The Journal of biological chemistry
Human NAD-dependent isocitrate dehydrogenase or IDH3 (HsIDH3) catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the tricarboxylic acid (TCA) cycle. It consists of three types of subunits (α, β, and γ), and exists and functions as the (αβαγ)2 heterooctamer. HsIDH3 is regulated allosterically and/or competitively by numerous metabol...
Published in Autophagy
Substrates that are selected for degradation by autophagy interact in more complex eukaryotes with Atg8-family proteins via the LC3-interacting region (LIR) that is often preceded by either acidic residues or phosphorylated serine or threonine. These upstream amino acid residues increase the binding affinity of the LIR motif to its binding site on ...
This project aimed to establish a way to modulate the supramolecular chemistry and spin crossover properties of metal complexes through the use of anionic supramolecular networks. This research employed crystal engineering to effectively combine several molecular building blocks within the same crystalline material. The arrangement of these compone...
Glutathione transferases (GSTs) constitute a widespread superfamily of enzymes notably involved in detoxification processes and/or in specialized metabolism. In the cyanobacterium Synechocsytis sp. PCC 6803, SynGSTC1, a chi-class GST (GSTC), is thought to participate in the detoxification process of methylglyoxal, a toxic by-product of cellular met...
Published in The Journal of biological chemistry
Mitochondria harbor the bacteria-inherited iron-sulfur cluster assembly (ISC) machinery to generate [2Fe-2S; iron-sulfur (Fe-S)] and [4Fe-4S] proteins. In yeast, assembly of [4Fe-4S] proteins specifically involves the ISC proteins Isa1, Isa2, Iba57, Bol3, and Nfu1. Functional defects in their human equivalents cause the multiple mitochondrial dysfu...
The history of tobacco mosaic virus (TMV) includes many firsts in science, beginning with its being the first virus identified. This review offers an overview of a history of research on TMV, with an emphasis on its close connections to the emergence and development of molecular biology.
Published in Journal of molecular cell biology
In the fission yeast Schizosaccharomyces pombe, Mei2, an RNA-binding protein essential for entry into meiosis, regulates meiosis initiation. Mei2 binds to a specific non-coding RNA species, meiRNA, and accumulates at the sme2 gene locus, which encodes meiRNA. Previous research has shown that the Mei2 C-terminal RNA recognition motif (RRM3) physical...
Published in Molecular pharmaceutics
Crystal polymorphism is a common phenomenon in pharmaceutical solids and a critical issue when considering the formulation of therapeutics since multiple polymorphs may form during drug manufacturing. Low-frequency vibrational spectroscopy is sensitive to polymorphic content, and in this work, terahertz time-domain spectroscopy and low-frequency Ra...
Published in Frontiers in Marine Science
Structural and physiochemical properties contribute to the biological adaptation of deep-sea animals to their harsh living environment but have hardly been investigated systematically. In the present study, we for the first time applied various material characterization techniques including transmission electron microscopy (TEM), scanning electron ...
