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with costimulatory signal as keyword
Okada, Hiroyuki Okabe, Koji Tanaka, Sakae
Published in
International Journal of Molecular Sciences
Calcium (Ca2+) plays an important role in regulating the differentiation and function of osteoclasts. Calcium oscillations (Ca oscillations) are well-known phenomena in receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastogenesis and bone resorption via calcineurin. Many modifiers are involved in the fine-tuning of Ca osci...
Zhao, Yongbo Zheng, Qingliang Jin, Liping
Published in
Frontiers in Immunology
Pregnancy is a complex but well-arranged process, and a healthy fetus requires immune privilege and surveillance in the presence of paternally derived antigens. Maternal and fetal cells interact at the maternal–fetal interface. The upregulation and downregulation of maternal immunity executed by the leukocyte population predominantly depend on the ...
Liu, Shangjing He, Junlin Chen, Xuemei Ding, Yubin Geng, Yanqing Wu, Mengyun Liu, Xueqing Wang, Yingxiong
Published in
Reproductive Sciences
Embryo implantation is a complex process requiring reciprocal interactions between implantation-competent blastocysts and receptive uteri. Accumulating literatures have indicated that T cells are involved in this process. The first signal mediated by T-cell receptor/CD3 complex and the second signal delivered by costimulatory molecules are essentia...
Li, Min Jiang, Jiandong Fu, Bing Chen, Jiechun Xue, Qun Dong, Wanli Gu, Yanzheng Tang, Lingtao Xue, Limin Fang, Qi
...
Published in
Neural regeneration research
Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic enc...
Maeda, Masatoshi Ito, Yuji Hatanaka, Takaaki Hashiguchi, Shuhei Torikai, Masaharu Nakashima, Toshihiro Sugimura, Kazuhisa
Published in
mAbs
A costimulatory signal is required for the full activation of T cells, in addition to the antigen-specific signal via the T cell receptor. The inducible costimulator, ICOS is one of the costimulatory molecules that play an essential role in this process, particularly in the expansion or the development of effector T cells. As blocking of the intera...
Arai, Kosuke Sunamura, Makoto Wada, Yasushi Takahashi, Motoyoshi Kobari, Masao Kato, Kazunori Yagita, Hideo Okumura, Ko Matsuno, Seiki
Published in
International Journal of Pancreatology
Immunosuppressive potentials of the blockade of intercellular adhesion molecule-1 (ICAM)-1/leukocyte function-associated antigen 1 (LFA-1) were examined in a murine islet allotransplantation model by using blocking monoclonal antibodies (MAbs) against these molecules. Isolated islets from ICR mice were transplanted into the renal subcapsular space ...
