Akakuru, Ozioma Udochukwu Onyido, Ikenna
Published in
Macromolecular Research
Controlled release formulations (CRFs) of 2,4-dichlorophenoxyacetic acid (2,4-D) with chitosan (CTS) and chitosan-starch (CTS-STA) matrices were prepared in their un-crosslinked and crosslinked forms. Pesticide-matrix interactions were probed by FT-IR, while TGA and SEM provided information on the morphological characteristics of the pesticide-load...
Sun, Congyong Li, Wenjing Zhang, Huiyun Adu-Frimpong, Michael Ma, Ping Zhu, Yuan Deng, Wenwen Yu, Jiangnan Xu, Ximing
Published in
AAPS PharmSciTech
This study aimed to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the solubility, oral bioavailability, and hypolipidemic effects of syringic acid (SA), a bioactive and poorly-soluble polyphenol. Based on the response surface methodology-central composite design (RSM-CCD), an optimum formulation of SA-SMEDDS, consisting o...
Wen, Weiqiu Guo, Chong Guo, Jianwei
Published in
Nanomaterials
Four-arm star-shaped (denoted as ‘S’) polymer adamantane-[poly(lactic- co -glycolic acid)- b -poly( N,N’ -diethylaminoethyl methacrylate) poly(ethylene glycol) monomethyl ether]4 (S-PLGA-D-P) and its linear (denoted as ‘L’) counterpart (L-PLGA-D-P) were synthesized, then their self-assembled micelles were further developed to be platforms for antic...
Fang, Dongyang Yang, Yining Cui, Mengsuo Pan, Hao Wang, Lijie Li, Pingfei Wu, Wenjing Qiao, Sen Pan, Weisan
Published in
AAPS PharmSciTech
In 2017, there are 451 million people with diabetes worldwide. These figures were expected to increase to 693 million by 2045. The research and development of hypoglycemic drugs has become a top priority. Among them, sulfonylurea hypoglycemic drugs such as glipizide are commonly used in non-insulin-dependent type II diabetes. In order to adapt to t...
Qi, Jing Zhou, Yang Hua, Jiao Zhang, Liying Bian, Jialin Liu, Beibei Zhao, Zicen Jin, Shuilin
Published in
International journal of environmental research and public health
COVID-19 patients always develop multiple organ dysfunction syndromes other than lungs, suggesting the novel virus SARS-CoV-2 also invades other organs. Therefore, studying the viral susceptibility of other organs is important for a deeper understanding of viral pathogenesis. Angiotensin-converting enzyme II (ACE2) is the receptor protein of SARS-C...
Liu, H. (author) Laan, A.C. (author) Plomp, J. (author) Parnell, S.R. (author) Men, Y. (author) Dalgliesh, Robert M. (author) Eelkema, R. (author) Denkova, A.G. (author)
Polymeric micelles, due to their easy preparation and versatile properties, have been widely applied as one of the most popular carriers for chemotherapeutic agents. Such micelles primarily prevent the leakage of drugs during transportation and thus protect healthy tissue. Controlled drug release, which releases the drugs at the site of interest us...
Nifant’ev, Ilya Siniavin, Andrei Karamov, Eduard Kosarev, Maxim Kovalchuk, Sergey Turgiev, Ali Nametkin, Sergey Bagrov, Vladimir Tavtorkin, Alexander Ivchenko, Pavel
...
Published in
International Journal of Molecular Sciences
Despite the world’s combined efforts, human immunodeficiency virus (HIV), the causative agent of AIDS, remains one of the world’s most serious public health challenges. High genetic variability of HIV complicates the development of anti-HIV vaccine, and there is an actual clinical need for increasing the efficiency of anti-HIV drugs in terms of tar...
Marinas, Ioana Cristina Oprea, Eliza Geana, Elisabeta-Irina Tutunaru, Oana Pircalabioru, Gratiela Gradisteanu Zgura, Irina Chifiriuc, Mariana Carmen
Published in
International Journal of Molecular Sciences
Gleditsia triacanthos is an aggressive invasive species in Eastern Europe, producing a significant number of pods that could represent an inexhaustible resource of raw material for various applications. The aim of this study was to extract cellulose from the Gleditsia triacanthos pods, characterize it by spectrophotometric and UHPLC–DAD-ESI/MS anal...
Wu, Chia-Lin Tarng, Der-Cherng
Published in
Toxins
Chronic kidney disease (CKD) exhibits progressive kidney dysfunction and leads to disturbed homeostasis, including accumulation of uremic toxins, activated renin-angiotensin system, and increased oxidative stress and proinflammatory cytokines. Patients with CKD are prone to developing the peripheral vascular disease (PVD), leading to poorer outcome...
Guo, Hao Zhang, Runmiao Han, Ying Wang, Jin Yan, Chaoguo
Published in
Frontiers in Chemistry
