Patil, Hemlata Vemula, Sateesh Kumar Narala, Sagar Lakkala, Preethi Munnangi, Siva Ram Narala, Nagarjuna Jara, Miguel O Williams, Robert O 3rd Terefe, Hibreniguss Repka, Michael A
...
Published in
AAPS PharmSciTech
Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers an efficient continuous manufacturing process. The twin-screw extruder (TSE) offers an extremely resourceful customizable mixer that is used for continuous compounding and g...
Che, Shiyi Feng, Xue Li, Zhengjun Su, Zhiguo Ma, Guanghui Li, Zhikao Yu, Aibing Liu, Minsu Zhang, Songping
Published in
Biotechnology and bioengineering
The messenger RNA (mRNA) 5'-cap structure is indispensable for mRNA translation initiation and stability. Despite its importance, large-scale production of capped mRNA through in vitro transcription (IVT) synthesis using vaccinia capping enzyme (VCE) is challenging, due to the requirement of tedious and multiple pre-and-post separation steps causin...
Chatterjee, Bikash Steiner, Richard Kaul, Goldi
Published in
Pharmaceutical research
Monbaliu, Jean-Christophe
Romann, Patrick Schneider, Sebastian Tobler, Daniela Jordan, Martin Perilleux, Arnaud Souquet, Jonathan Herwig, Christoph Bielser, Jean-Marc Villiger, Thomas K
Published in
Biotechnology journal
Despite technological advances ensuring stable cell culture perfusion operation over prolonged time, reaching a cellular steady-state metabolism remains a challenge for certain manufacturing cell lines. This study investigated the stabilization of a steady-state perfusion process producing a bispecific antibody with drifting product quality attribu...
Rotar Pucko, Eva
Temeljna zahteva farmacevtske industrije je izdelava kakovostnih, varnih in učinkovitih zdravil. Na tem področju prevladujejo klasični šaržni proizvodni procesi, v zadnjem času pa se zaradi naraščajočih potreb po večji časovni in cenovni učinkovitosti ter prilagodljivosti potrebam trga uveljavlja tudi kontinuirana proizvodnja zdravil. Ta je podprta...
Politis, Maria D Yao, Meizhen Gennings, Chris Tamayo-Ortiz, Marcela Valvi, Damaskini Kim-Schulze, Seunghee Qi, Jingjing Amarasiriwardena, Chitra Pantic, Ivan Tolentino, Mari Cruz
...
Published in
Toxics
Prenatal exposure to arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) may be nephrotoxic, yet limited studies have examined subclinical kidney injury biomarkers in children. We assessed whether metal exposure in the second trimester (2T), a crucial time of kidney development, is associated with altered urine kidney injury and function biomar...
Aragoneses, Javier Suárez, Ana Rodríguez, Cinthia Algar, Juan Aragoneses, Juan Manuel
Published in
Antibiotics (Basel, Switzerland)
In this study, we aimed to explore the trends among dentists in the Dominican Republic of providing antibiotic prescriptions to pregnant/breastfeeding dental patients. A survey was conducted among 98 dentists, using a self-administered questionnaire, about their knowledge and attitudes regarding antibiotic usage in pregnant/lactating women and the ...
Munjal, Bhushan DeBoyace, Kevin Cao, Fengjuan Krzyzaniak, Joseph F Arora, Kapildev K Suryanarayanan, Raj
Published in
Molecular pharmaceutics
In recent years, continuous tablet manufacturing technology has been used to obtain regulatory approval of several new drug products. While a significant fraction of active pharmaceutical ingredients exists as hydrates (wherein water is incorporated stoichiometrically in the crystal lattice), the impact of processing conditions and formulation comp...
ADALI, MERVE BETUL
L'abstract è presente nell'allegato / the abstract is in the attachment
