Muggli, Zélia Mertens, Thierry -Sá, Silva Amado, Regina Teixeira, Ana L Vaz, Dora O Martins, Maria Rosário
Published in
International journal of environmental research and public health
The role of migration as a determinant in child mental health has been demonstrated in a number of studies. However, results are not always consistent, and the research continues to be scarce, especially in Portugal. We examined the association between sociodemographic profiles and the chance for the development of emotional and behavioral difficul...
González, Luis Alonso Ugarte-Gil, Manuel Francisco Alarcón, Graciela S
Published in
Lupus
During the last decades, there has been an increased interest in the discovery and validation of biomarkers that reliably reflect specific aspects of lupus. Although many biomarkers have been developed, few of them have been validated and used in clinical practice, but with unsatisfactory performances. Thus, there is still a need to rigorously vali...
Jager, Martine J. Seddon, Johanna M.
Many of the risk factors for developing severe coronavirus disease 2019 (COVID-19) are also risk factors for eye diseases such as age-related macular degeneration (AMD). During the past decades, macrophages and the complement pathway (as a part of the innate immune system) have been identified as important contributors to the development of AMD, an...
Park, Seohyun Kim, Hyung Woo Park, Jung Tak Chang, Tae Ik Kang, Ea Wha Ryu, Dong-Ryeol Yoo, Tae-Hyun Chin, Ho Jun Jeong, Hyeon Joo Kang, Shin-Wook
...
Published in
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Complement activation has been highlighted in immunoglobulin (Ig) A nephropathy pathogenesis. However, whether the complement system can affect the downstream phenotype of IgA nephropathy remains unknown. Herein, we investigated the association of mesangial C3 deposition with the Oxford classification and their joint effects on worsening kidney fun...
Zelek, Wioleta Milena Fathalla, Dina Morgan, Angharad Touchard, Samuel Loveless, Samantha Tallantyre, Emma Robertson, Neil P Morgan, B Paul
Published in
Multiple sclerosis (Houndmills, Basingstoke, England)
Multiple sclerosis (MS) can be difficult to differentiate from other demyelinating diseases, notably neuromyelitis optica spectrum disorder (NMOSD). We previously showed that NMOSD is distinguished from MS by plasma complement biomarkers. Here, we measure cerebrospinal fluid (CSF) complement proteins in MS, NMOSD and clinically isolated syndrome (C...
Griffin, Percy Sheehan, Patrick W Dimitry, Julie M Guo, Chun Kanan, Michael F Lee, Jiyeon Zhang, Jinsong Musiek, Erik S
Published in
eLife
The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and C3, in the hippocampus. BMAL1 regulates expression of the transcriptional repressor REV-ERBα, and de...
Marcos-Jiménez, Ana Sánchez-Alonso, Santiago Alcaraz-Serna, Ana Esparcia, Laura López-Sanz, Celia Sampedro-Núñez, Miguel Mateu-Albero, Tamara Sánchez-Cerrillo, Ildefonso Martínez-Fleta, Pedro Gabrie, Ligia
...
Published in
European journal of immunology
SARS-CoV-2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome of COVID-19. We investigated whether the specific immune responses in the peripheral blood of 276 patients associated to severity and progression of COVID-19. At admission, dramatic lymphopenia of T, B and NK cells associated to se...
Nagata, Keiko Hayashi, Kazuhiko
Published in
Microorganisms
Epstein-Barr virus (EBV) mainly persists in B cells, which differentiate into antibody-producing cells, and thus, EBV has been implicated in autoimmune diseases. We aimed to describe the EBV reactivation and its relevance to autoimmune disease, focusing on Graves' disease, which is an autoimmune hyperthyroidism caused by thyrotropin receptor antibo...
Chéneau, Coraline Kremer, Eric J
Published in
Viruses
The aim of this review is to highlight how, in a syngeneic system, human mononuclear phagocytes respond to environments containing human adenovirus (HAdV) and soluble extracellular proteins that influence their innate immune response. Soluble extracellular proteins, including immunoglobulins, blood clotting factors, proteins of the complement syste...
Strayer, Ethan C Lu, Stephen Ribeiro, Jose M Andersen, John F
Published in
The Journal of biological chemistry
Inhibition of the alternative pathway (AP) of complement by saliva from Anopheles mosquitoes facilitates feeding by blocking production of the anaphylatoxins C3a and C5a which activate mast cells leading to plasma extravasation, pain and itching. We have previously shown that albicin, a member of the SG7 protein family from An. albimanus blocks the...
