Background: Colorectal cancer (CRC) incidence rates have remained stable in the United States (U.S.) the past 30 years, however, there has been a significant increase in CRC incidence among the millennial generation. The association between the Western diet and CRC, and racial and gender disparities in CRC is well-established. Public health and com...
Background: Colorectal cancer (CRC) incidence rates have remained stable in the United States (U.S.) the past 30 years, however, there has been a significant increase in CRC incidence among the millennial generation. The association between the Western diet and CRC, and racial and gender disparities in CRC is well-established. Public health and com...
Background: Colorectal cancer (CRC) incidence rates have remained stable in the United States (U.S.) the past 30 years, however, there has been a significant increase in CRC incidence among the millennial generation. The association between the Western diet and CRC, and racial and gender disparities in CRC is well-established. Public health and com...
Patients with colorectal cancer are frequently presented with liver metastases for which (partial) resection is often the best therapy. However, the future remnant liver, the remaining part of the liver after resection, should allow adequate liver function to avoid liver failure. This thesis presents novel methods for the accurate voxel-wise estima...
Patients with colorectal cancer are frequently presented with liver metastases for which (partial) resection is often the best therapy. However, the future remnant liver, the remaining part of the liver after resection, should allow adequate liver function to avoid liver failure. This thesis presents novel methods for the accurate voxel-wise estima...
Patients with colorectal cancer are frequently presented with liver metastases for which (partial) resection is often the best therapy. However, the future remnant liver, the remaining part of the liver after resection, should allow adequate liver function to avoid liver failure. This thesis presents novel methods for the accurate voxel-wise estima...
s two-hit hypothesis. Somatic mutational profiling and signature analysis were also performed. A series of germline-somatic variant pairs were detected. In all cases, the first hit was presented as a rare SNV/indel, whereas the second hit was either a different SNV (3 genes) or LOH affecting the same gene (141 genes). BRCA2, BLM, ERCC2, RECQL, REV3...
8.16), respectively. Neither serum genistein nor luteolin was associated with CRC prognosis. There was no clear evidence of departure from linearity. However, the association might be differential by adjuvant chemotherapy. Associations pointed towards lower risk in patients who received chemotherapy and higher risk in those without chemotherapy for...
microRNAs (miRNA) expression in colorectal (CR) primary tumours can facilitate a more precise molecular characterization. We identified and validated a miRNA profile associated with clinical and histopathological features that might be useful for patient stratification. In situ hybridization array using paraffin-embedded biopsies of CR primary tumo...
-catenin, Notch, STAT3, and Hedgehog pathways. In this review, we aim to review some of the ongoing CSC therapeutic targeting strategies in gastrointestinal malignancies.
