Yang, Hongju Li, Qian Wu, Yanrui Dong, Jianlong Lao, Yaling Ding, Zheng Xiao, Changyan Fu, Jinxiao Bai, Song
Published in
Oncology reports
Accumulating evidence has shown that long non‑coding RNAs (lncRNAs) play significant roles in the development and progression of many types of cancer including colorectal cancer. RP11‑400N13.3 is a novel lncRNA discovered recently and its biological function and underlying mechanism in colorectal cancer remain elusive. This study aimed to reveal th...
Wang, Ximin Tao, Geng Huang, Donghong Liang, Shuangyin Zheng, Dongxu
Published in
Oncology reports
Colorectal cancer (CRC) is a common malignancy globally. The aim of the present study was to explore the role and the working mechanism of circular RNA NADPH oxidase 4 (circNOX4; circBase ID, hsa_circ_0023990) in CRC. Reverse transcription‑quantitative (RT‑q)PCR was used to examine the expression of circNOX4, NOX4 mRNA and microRNA (miR)‑485‑5p in ...
Smolenschi, Cristina Perret, Audrey Dall'Armellina, François Boige, Valerie Malka, David Hollebecque, Antoine Ducreux, Michel
Published in
Expert review of gastroenterology & hepatology
Despite a significant improvement in overall survival over the last 15 years, colorectal cancer remains a major public health problem worldwide. Much effort has been made to develop an optimal choice of first-line treatments, but after progression the therapeutic possibilities and the criteria for choice are different. . The purpose of this literat...
Liu, Jing-Wen Yu, Fei Tan, Yuan-Fei Huo, Jian-Ping Liu, Zhao Wang, Xiao-Jing Li, Jian-Ming
Published in
Cancer biotherapy & radiopharmaceuticals
Background: Tumor microenvironment (TME) significantly affects colorectal cancer (CRC) progression and therapeutic efficacy, particularly the infiltrating stromal components. This study aimed to profile the TME composition of tumor tissue and identify TME-related, especially stroma-related genes having prognosis value in CRC patients. Materials and...
Sukhokanjanachusak, Kanjana Pongpaibul, Ananya Nimmannit, Akarin Akewanlop, Charuwan Korphaisarn, Krittiya
Published in
Journal of adolescent and young adult oncology
Purpose: Colorectal cancer (CRC) incidence is increasing in adults younger than 50 years. This study evaluated clinicopathological characteristics and outcome of adolescent and young adult (AYA)-onset sporadic CRC patients. Methods: Medical records of patients who were diagnosed adenocarcinoma of colon or rectum at Siriraj Hospital between 2007 and...
Ruan, Zhiyan Deng, Hongling Liang, Minhua Xu, Zhe Lai, Manxiang Ren, Hong Deng, Xiangliang Su, Xinguo
Published in
Cancer Cell International
Background Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAFG-AS1) could regulate biologic...
Wang, Xin Wang, Jian Wu, Jingjing
Published in
Translational Oncology
• HMGA2 promotes colorectal cancer (CRC) development by regulating the transcriptions of target genes. • Circulating cell-free HMGA2 mRNA has been identified as a potential screening marker in CRC. • HMGA2 appears to be a key factor in the networks of MDM2/p53, IL11/STAT3 and Wnt/β-catenin signaling pathways in CRC. • Many agents and siRNAs serve a...
Salinas, Jennifer Brito, Jacquelyn Rincones, Cheyenne Shokar, Navkiran K
Published in
BMJ Open
Objective This study examines the geographical and socioeconomic factors associated with uptake of colorectal cancer (CRC) screening (colonoscopies or faecal immunochemical test (FIT) testing). Design Secondary data analysis. Setting The Against Colorectal Cancer in our Community (ACCION) programme was implemented in El Paso County, Texas, to incre...
Lin, Jiatian Fan, Xiaoqin Chen, Junhui Xie, Xina Yu, Hongjian
Published in
Experimental and Therapeutic Medicine
Colorectal cancer (CRC) is the third most common cancer in the world and its development is associated with oncogenic dysfunction. Therefore, the present study aimed to identify differentially expressed genes (DEGs) in CRC tissues and to determine the role of keratin 80 (KRT80) in CRC cell proliferation. DEGs were initially screened in 32 paired CR...
Agbana, Preye Lee, Min Jae Rychahou, Piotr Kim, Kyung-Bo Bae, Younsoo
Published in
Pharmaceutical Research
PurposeTo develop a new nanoparticle formulation for a proteasome inhibitor Carfilzomib (CFZ) to improve its stability and efficacy for future in vivo applications.MethodsCFZ-loaded ternary polypeptide nanoparticles (CFZ/tPNPs) were prepared by using heptakis(6-amino-6-deoxy)-β-cyclodextrin(hepta-hydrochloride) (HaβCD) and azido-poly(ethylene glyco...
