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Monitoring DOACs with a Novel Dielectric Microsensor: A Clinical Study.

Published in Thrombosis and haemostasis

There are acute settings where assessing the anticoagulant effect of direct oral anticoagulants (DOACs) can be useful. Due to variability among routine coagulation tests, there is an unmet need for an assay that detects DOAC effects within minutes in the laboratory or at the point of care. We developed a novel dielectric microsensor, termed ClotChi...

Coagulation tests on admission correlate with mortality and morbidity in general ICU patients: An observational study.

Published in Acta anaesthesiologica Scandinavica

It is well known that low platelet count on admission to intensive care units (ICU) is associated with increased mortality. However, it is unknown whether prothrombin time (PT-INR) and activated partial thromboplastin time (APTT) on admission correlate with mortality and organ failure. Therefore, the aim of this study was to investigate whether PT-...

Effect of heparin thromboprophylaxis on thrombin generation in multiple myeloma patients.

Published in British journal of haematology

Retrospective comparison of standard clotting tests and novel clot waveform parameters in dogs using the turbidimetric A...

Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

Clot waveforms are generated by coagulation analyzers, such as the ACL-TOP, that utilize photo-optical turbidimetric methods to measure prothrombin time (PT) and activated partial thromboplastin time (aPTT), which are standard clotting tests (SCTs). Additional quantitative clot waveform analysis (CWA) parameters include maximum velocity of the PT c...

Agreement of point-of-care prothrombin and activated partial thromboplastin time in dogs with a reference laboratory.

Published in Australian veterinary journal

To determine the agreement, sensitivity, specificity and accuracy of prothrombin (PT) and activated partial thromboplastin time (aPTT) using the point-of-care analyser SCA2000™ with IDEXX Coag Dx™ cartridges against a reference laboratory (STAGO Start 4®) in canine blood. Citrated blood samples from 47 dogs were submitted for PT and aPTT measuremen...

Is thromboelastography (TEG)-based resuscitation better than empirical 1:1 transfusion?

Published in Trauma surgery & acute care open

Thomboelastography (TEG) is a whole blood measure of coagulation which was originally described in the 1950s. However, it has only been in the last few decades that assays have become accessible and viable as a point-of-care test. Following the observation that hemorrhagic shock is associated with an intrinsic coagulopathy, TEG has been used as a m...

Thromboelastography for Assessing the Risk of Bleeding in Patients With Cirrhosis-Moving Closer.

Published in Journal of clinical and experimental hepatology

Conventional coagulation tests (CCTs) in patients with cirrhosis only assess procoagulant factors and are poor predictors of bleeding risk. In spite of this knowledge, they are routinely used prior to invasive procedures, and attempts are made to correct these abnormalities before invasive procedures. These practices are not supported by the eviden...

A Review of the Current Role of Blood Clotting Analyzers in Clinical Practice.

Published in Cardiovascular & hematological disorders drug targets

This review provides a summary of clinical trials utilizing VETs in the aforementioned clinical scenarios, and suggests that VETs have demonstrated a capability to identify coagulopathies, utility in guiding algorithms to reduce the amount of transfusions, and a limited ability to predict bleeding events or mortality.