Lim, Lew
Published in
Frontiers in Neurology
This manuscript outlines a model of Alzheimer’s Disease (AD) pathophysiology in progressive layers, from its genesis to the development of biomarkers and then to symptom expression. Genetic predispositions are the major factor that leads to mitochondrial dysfunction and subsequent amyloid and tau protein accumulation, which have been identified as ...
xue, chongxiang chen, ying yuntian, bi yang, xiaofei chen, keyu tang, cheng tong, xiaolin zhao, linhua wang, han
Diabetes is a widespread chronic disease that occurs mainly in the elderly population. Due to the difference in pathophysiology between elderly and young patients, the current clinical practice to treat elderly patients with anti-diabetes medications still faces some challenges and dilemmas, such as the urgent need for early diagnosis and preventio...
Guo, Liuli Yang, Zhihua Feng, Wenshuai Liu, Yiman Li, Zhenzhen Zhuang, Pengwei Ren, Ming
Published in
Frontiers in Cardiovascular Medicine
Refractory heart failure (RHF), or end-stage heart failure, has a poor prognosis and high case fatality rate, making it one of the therapeutic difficulties in the cardiovascular field. Despite the continuous abundance of methods and means for treating RHF in modern medicine, it still cannot meet the clinical needs of patients with RHF. How to furth...
Molina Cuevas, Vivian Oyarzábal Yera, Ambar
Published in
Exploration of Neuroscience
Stroke is among the leading causes of mortality and disability; therefore, it constitutes a relevant health problem. Cuban policosanol presents lipid-lowering, antiplatelet, antioxidant and vascular endothelium protective properties, all of which give it a comprehensive anti-atherosclerotic effect. This review is aimed to show, analyze and discuss ...
Song, Alfred Rensi, Stefano E Tarquinio, Abigail G Cahan, Eli de Ruijter, Vivian E Wall, James K
Published in
Surgical innovation
Clinical trials represent a significant risk in the commercialization of surgical technologies. There is incentive for companies to mitigate their regulatory risk by targeting 510K over Premarket Approval (PMA) pathways in order to limit the scope, complexity and cost of clinical trials. As such, not all companies will publish clinical data in the ...
lee, sun-young lorant, gergo grand, laszlo szasz, attila marcell
The mEHT method uses tissues’ thermal and bioelectromagnetic heterogeneity for the selective mechanisms. The success of the therapy for advanced, relapsed, and metastatic aggressive tumors can only be demonstrated by measuring survival time and quality of life (QoL). The complication is that mEHT-treated patients cannot be curatively treated any lo...
Charrière, Karine Pazart, Lionel
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
In May 2022, the European Regulation 2017/746 (IVDR) came into force. It changes the approach of in vitro medical devices (IVD-MDs) for industry and institutions. It reinforces the clinical evidence requirements to improve performance, safety and transparency. Despite extended transition periods and existing guides, IVDR remains difficult to interp...
abraham, ivo lewandrowski, kai-uwe elfar, john c. zong-ming, li alvim fiorelli, rossano kepler pereira, mauricio g. lorio, morgan p. burkhardt, benedikt w. oertel, joachim m. winkler, peter a.
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Proving clinical superiority of personalized care models in interventional and surgical pain management is challenging. The apparent difficulties may arise from the inability to standardize complex surgical procedures that often involve multiple steps. Ensuring the surgery is performed the same way every time is nearly impossible. Confounding facto...
van de vliet, peter sprenger, tobias c. kampers, linde f. makalowski, jennifer schirrmacher, volker stücker, wilfried van gool, stefaan w.
The fundamental aim of healthcare is to improve overall health of the population by providing state-of-the-art healthcare for individuals at an affordable cost. The foundation for this system is largely referred to as “evidence-based medicine”. Too often, evidence-based medicine is based solely on so-called “best research evidence”, collected throu...
Yang, Zhihua Liu, Yangxi Song, Zhihui Fan, Yujian Lin, Shanshan Ge, Zhao Feng, Shaoling Liu, Yu Bi, Yingfei Wang, Yi
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Published in
International Journal of Medical Sciences
Coronary microvascular disease (CMVD) is a high risk factor for many cardiovascular events. Due to the limited understanding of its pathophysiological mechanism, modern medicine still lacks therapeutic drugs for CMVD. Existing clinical studies have shown that traditional Chinese medicine (TCM) can effectively improve the clinical symptoms and quali...