Fukai, Katsuhiko Nishi, Tatsuya Yamada, Manabu Ikezawa, Mitsutaka
Published in
Veterinary Research
We analyzed the pathogenicity of a recent Japanese classical swine fever virus (CSFV) to wild boars via an experimental infection using boar-pig hybrids as an alternative to wild boars. We also investigated the effectiveness of a bait vaccine against the CSFV. Naïve boar-pig hybrids and pigs showed clinical signs such as fever, leucopenia, anorexia...
Fan, Shuangqi Wu, Keke Zhao, Mingqiu Yuan, Jin Ma, Shengming Zhu, Erpeng Chen, Yuming Ding, Hongxing Yi, Lin Chen, Jinding
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Published in
Autophagy
Cellular metabolism caters to the energy and metabolite needs of cells. Although the role of the terminal metabolic enzyme LDHB (lactate dehydrogenase B) in the glycolysis pathway has been widely studied in cancer cells, its role in viral infection is relatively unknown. In this study, we found that CSFV (classical swine fever virus) infection redu...
Li, Wenhui Zhang, Zilin Zhang, Liangliang Li, Hong Fan, Shuangqi Zhu, Erpeng Fan, Jindai Li, Zhaoyao Chen, Wenxian Yi, Lin
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Published in
Frontiers in Microbiology
Serine incorporator 5 (SERINC5), a multipass transmembrane protein, protects cells from viral infections. The mechanism by which SERINC5 protects against classical swine fever virus (CSFV) infection is unknown. In this study, overexpression of SERINC5 in PK-15 and 3D4/2 cells significantly inhibited the growth of CSFV, whereas SERINC5 silencing enh...
Malik, Yashpal Singh Bhat, Sudipta Kumar, O. R. Vinodh Yadav, Ajay Kumar Sircar, Shubhankar Ansari, Mohd Ikram Sarma, Dilip Kumar Rajkhowa, Tridib Kumar Ghosh, Souvik Dhama, Kuldeep
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Published in
Pathogens
Classical swine fever (CSF) is an economically significant, multi-systemic, highly contagious viral disease of swine world over. The disease is notifiable to the World Organization for Animal Health (OIE) due to its enormous consequences on porcine health and the pig industry. In India, the pig population is 9.06 million and contributes around 1.7%...
Chen, Yuming Fan, Shuangqi Zhao, Mengpo Wu, Keke Zhu, Erpeng Ma, Shengming He, Wencheng Deng, Shaofeng Xu, Hailuan Zhang, Jingyuan
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Published in
Frontiers in Microbiology
The 26S proteasome, in charge of intracellular protein degradation, plays significant roles in the modulation of various cellular activities as well as in the interplay between virus and host. However, studies about the relationship between 26S proteasome and classical swine fever virus (CSFV) is limited up to now. MG132 is a proteasome inhibitor a...
Bohórquez, José Alejandro Muñoz-González, Sara Pérez-Simó, Marta Muñoz, Iván Rosell, Rosa Coronado, Liani Domingo, Mariano Ganges, Llilianne
Published in
Pathogens
Classical swine fever virus (CSFV) induces trans-placental transmission and congenital viral persistence; however, the available information is not updated. Three groups of sows were infected at mid-gestation with either a high, moderate or low virulence CSFV strains. Foetuses from sows infected with high or low virulence strain were obtained befor...
Vuono, Elizabeth A. Ramirez-Medina, Elizabeth Azzinaro, Paul Berggren, Keith A. Rai, Ayushi Pruitt, Sarah Silva, Ediane Velazquez-Salinas, Lauro Borca, Manuel V. Gladue, Douglas P.
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Published in
Viruses
E2 is the major structural glycoprotein of the classical swine fever virus (CSFV). E2 has been shown to be involved in important virus functions such as replication and virulence in swine. Using the yeast two-hybrid system, we previously identified several host proteins specifically interacting with CSFV E2. Here, we analyze the protein interaction...
Huang, Yu-Liang Tsai, Kuo-Jung Deng, Ming-Chung Liu, Hsin-Meng Huang, Chin-Cheng Wang, Fun-In Chang, Chia-Yi
Published in
Pathogens
In Taiwan, the prevalent CSFV population has shifted from the historical genotype 3.4 (94.4 strain) to the newly invading genotype 2.1 (TD/96 strain) since 1996. This study analyzed the competition between these two virus genotypes in dual infection pigs with equal and different virus populations and with maternally derived neutralizing antibodies ...
Yin, Mei Hu, Dongfang Li, Peng Kong, Lingyun Ning, Hongmei Yue, Feng Jiang, Jinqing Wang, Xuannian
Published in
Journal of Veterinary Research
Introduction Classical swine fever virus (CSFV) causes an economically important and highly contagious disease of pigs, leading to economic losses around the world. Attenuated live vaccines with CSFV antigens have played an important role in the prevention and control of the disease. Porcine kidney 15 (PK15) cells have been widely used for the prop...
Zheng, Guanglai Li, Lian-Feng Zhang, Yuexiu Qu, Liang Wang, Wenjing Li, Miao Yu, Shaoxiong Zhou, Mo Luo, Yuzi Sun, Yuan
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Published in
Emerging Microbes & Infections
Classical swine fever virus (CSFV) is a member of the genus Pestivirus in the Flaviviridae family. To date, the host factors required for CSFV entry remain poorly characterized. To identify the functional membrane protein(s) involved in CSFV infection, we analyzed the transcriptomic data from previous studies describing gene expression profiles for...
