Ramezani, Matin Fernando, Malika Eslick, Shaun Asih, Prita R. Shadfar, Sina Bandara, Ekanayaka M. S. Hillebrandt, Heidi Meghwar, Silochna Shahriari, Maryam Chatterjee, Pratishtha
...
Published in
Frontiers in Neuroscience
Alzheimer’s disease (AD) is the most common form of dementia. AD is a progressive neurodegenerative disorder characterized by cognitive dysfunction, including learning and memory deficits, and behavioral changes. Neuropathology hallmarks of AD such as amyloid beta (Aβ) plaques and neurofibrillary tangles containing the neuron-specific protein tau i...
Pascut, Devis Giraudi, Pablo J. Banfi, Cristina Ghilardi, Stefania Tiribelli, Claudio Bondesan, Adele Caroli, Diana Minocci, Alessandro Grugni, Graziano Sartorio, Alessandro
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Published in
Frontiers in Endocrinology
Introduction Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by loss of expression of paternal chromosome 15q11.2-q13 genes. Individuals with PWS exhibit unique physical, endocrine, and metabolic traits associated with severe obesity. Identifying liver steatosis in PWS is challenging, despite its lower prevalence compared to no...
Giorgia, Querin Gomez Garcia de la Banda, Marta Smeriglio, Piera
Published in
Frontiers in Neurology
Spinal muscular atrophy (SMA) is a lower motor neuron disease due to biallelic mutations in the SMN1 gene on chromosome 5. It is characterized by progressive muscle weakness of limbs, bulbar and respiratory muscles. The disease is usually classified in four different phenotypes (1–4) according to age at symptoms onset and maximal motor milestones a...
Ren, Shuai Chen, Rong Wang, Zhongqiu
Published in
Frontiers in Oncology
Moschella, Federica Buccione, Carla Ruspantini, Irene Castiello, Luciano Rozo Gonzalez, Andrea Iacobone, Floriana Ferraresi, Virginia Palermo, Belinda Nisticò, Paola Belardelli, Filippo
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Published in
Frontiers in Oncology
Introduction Despite the recent approval of several therapies in the adjuvant setting of melanoma, tumor relapse still occurs in a significant number of completely resected stage III-IV patients. In this context, the use of cancer vaccines is still relevant and may increase the response to immune checkpoint inhibitors. We previously demonstrated sa...
Philippron, Annouck
Esophageal cancer is one of the most aggressive tumors ranked as the seventh most common cancer worldwide and sixth in cancer-related mortality overall. The overall 5-year survival in the high-income countries for patients diagnosed with esophageal cancer is less than 20%. The first part of my thesis (chapter 3) focusses on the histopathologic find...
Janssen, Joëlle J.E. Lagerwaard, Bart Nieuwenhuizen, Arie G. Escoté, Xavier Canela, Núria del Bas, Josep M. de Boer, Vincent C.J. Keijer, Jaap
Biomarkers are important in the assessment of health and disease, but are poorly studied in still healthy individuals with a (potential) different risk for metabolic disease. This study investigated, first, how single biomarkers and metabolic parameters, functional biomarker and metabolic parameter categories, and total biomarker and metabolic para...
Hensler, Michal; Rakova, Jana; Kasikova, Lenka; Lanickova, Tereza; Pasulka, Josef; Holicek, Peter; Hraska, Marek; Hrnciarova, Tereza; Kadlecova, Pavla; Schoenenberger, Andreu;
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Dendritic cells (DCs) have received considerable attention as potential targets for the development of novel cancer immunotherapies. However, the clinical efficacy of DC-based vaccines remains suboptimal, largely reflecting local and systemic immunosuppression at baseline. An autologous DC-based vaccine (DCVAC) has recently been shown to improve pr...
Fang, Si Holmes, Michael V Gaunt, Tom R Davey Smith, George Richardson, Tom G
Published in
eLife
Polygenic scores (PGS) are becoming an increasingly popular approach to predict complex disease risk, although they also hold the potential to develop insight into the molecular profiles of patients with an elevated genetic predisposition to disease. We sought to construct an atlas of associations between 125 different PGS derived using results fro...
maciejczyk;, mateusz
The toxic properties of ethanol are inextricably linked to oxidative stress. Despite many reports on the effects of alcohol dependence on blood redox homeostasis, there are no data on the oxidative stress profile in alcohol-poisoned cases. There are also no data on the diagnostic usefulness of redox biomarkers determined post-mortem in various biol...
