Malki, Ahmed ElRuz, Rasha Abu Gupta, Ishita Allouch, Asma Vranic, Semir Al Moustafa, Ala-Eddin
Published in
International journal of molecular sciences
Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause of cancer-related mortality rates worldwide. Although modern research was able to shed light on the pathogenesis of CRC and provide enhanced screening strategies, the prevalence of CRC is still on the rise. Studies showed several cellular signaling pathways d...
García-de-Teresa, Benilde Rodríguez, Alfredo Frias, Sara
Published in
Genes
Fanconi anemia (FA), a chromosomal instability syndrome, is caused by inherited pathogenic variants in any of 22 FANC genes, which cooperate in the FA/BRCA pathway. This pathway regulates the repair of DNA interstrand crosslinks (ICLs) through homologous recombination. In FA proper repair of ICLs is impaired and accumulation of toxic DNA double str...
Vargas-Rondón, Natalia Pérez-Mora, Erika Villegas, Victoria E. Rondón-Lagos, Milena
Published in
Cancer Biology & Medicine
Objective Chromosomal instability (CIN) is a hallmark of cancer characterized by cell-to-cell variability in the number or structure of chromosomes, frequently observed in cancer cell populations and is associated with poor prognosis, metastasis, and therapeutic resistance. Breast cancer (BC) is characterized by unstable karyotypes and recent repor...
Wu, Chiao-En Yeh, Da-Wei Pan, Yi-Ru Huang, Wen-Kuan Chen, Ming-Huang Chang, John Wen-Cheng Chen, Jen-Shi Wang, Yu-Chao Yeh, Chun-Nan
Published in
Life
Immune checkpoint inhibitors (ICIs) have become the standard of care in various cancers, although their predictive tools have not yet completely developed. Here, we aimed to exam the role of 70-gene chromosomal instability signature (CIN70) in cancers, and its association with previous predictors, tumor mutation burden (TMB), and microsatellite ins...
Dominic, Jerry Lorren Feroz, Shah Huzaifa Muralidharan, Abilash Ahmed, Asma Thirunavukarasu, Pragatheeshwar
Published in
Cureus
The diagnosis of synchronous colorectal cancer (CRC) is crucial as the management, including the extent of surgical resection, depends on it. There have been numerous studies on the clinicopathological features of synchronous CRC; however, only a few studies have discussed synchronous cancer treatment. The guidelines to best manage the synchronous ...
Lopes, Danilo Maiato, Helder
Published in
Cells
The “tubulin code” combines different α/β-tubulin isotypes with several post-translational modifications (PTMs) to generate microtubule diversity in cells. During cell division, specific microtubule populations in the mitotic spindle are differentially modified, but only recently, the functional significance of the tubulin code, with particular emp...
Fujita, Harumi Sasaki, Takashi Miyamoto, Tatsuo Akutsu, Silvia Natsuko Sato, Showbu Mori, Takehiko Nakabayashi, Kazuhiko Hata, Kenichiro Suzuki, Hisato Kosaki, Kenjiro
...
Published in
Aging Cell
We report an individual showing premature aging, instability of chromosome numbers, spindle assembly checkpoint failure, and a heterozygous missense mutation in CDC20 . The CDC20 mutant showed low binding affinity to BUBR1 in the formation of the mitotic checkpoint complex and induced spindle assembly checkpoint failure in vitro. The case is postul...
Fenech, Michael
Published in
Genes
This review describes the cytokinesis-block micronucleus (CBMN) cytome assay and its evolution into a molecular cytogenetic method of chromosomal instability (CIN). Micronuclei (MNi) originate from whole chromosomes or chromosome fragments that fail to segregate to the poles of the cell during mitosis. These lagging chromosomes are excluded from th...
Cunningham, Chelsea E. MacAuley, Mackenzie J. Vizeacoumar, Frederick S. Abuhussein, Omar Freywald, Andrew Vizeacoumar, Franco J.
Published in
Cancers
Simple Summary Many alterations specific to cancer cells have been investigated as targets for targeted therapies. Chromosomal instability is a characteristic of nearly all cancers that can limit response to targeted therapies by ensuring the tumor population is not genetically homogenous. Polo-like Kinase 1 (PLK1) is often up regulated in cancers ...
Serafini, Giulia Giordani, Giorgia Grillini, Luca Andrenacci, Davide Gargiulo, Giuseppe Cavaliere, Valeria
Published in
International journal of molecular sciences
Awd, the Drosophila homologue of NME1/2 metastasis suppressors, plays key roles in many signaling pathways. Mosaic analysis of the null awdJ2A4 allele showed that loss of awd gene function blocks Notch signaling and the expression of its target genes including the Wingless (Wg/Wnt1) morphogen. We also showed that RNA interference (RNAi)-mediated aw...
