Epigenetic biomarkers for cancer risk stratification and patient management
Published in Frontiers in Genetics
Published in Frontiers in Genetics
Since 2002, with the discovery of vacuoles in human sperm heads through high-magnification observation, the nature of these vacuoles has been the subject of much debate, and the benefit of selecting a non-vacuolated spermatozoon before injection (Intra-cytoplasmic Morphologically-selected Sperm Injection IMSI) remains controversial. In this review,...
In recent years, significant technical advances have been made to better observe the structure and the organization of chromatin. Many Hi-C data are now available in public databases, at different accuracy and resolution and for various species. Generally, the final results of Hi-C data analyses are summarized with the representation of “contact ma...
Published in Nature Communications
Here the authors show genome-wide chromatin changes and transcriptional reprogramming occur in response to heat stress in tomato, leading to the transient formation of promoter-enhancer contacts to drive the expression of heat-stress responsive genes. Furthermore, they show chromatin spatial reorganization requires HSFA1a, a transcription factor (T...
Published in Biochemistry and cell biology = Biochimie et biologie cellulaire
The 43rd Asilomar Chromatin, Chromosomes, and Epigenetics Conference was held in an entirely online format from 9 to 11 December 2021. The conference enabled presenters at various career stages to share promising new findings, and presentations covered modern chromatin research across an array of model systems. Topics ranged from the fundamental pr...
Published in Journal of animal science
Epigenetic modifications are phenotypic changes unrelated to the modification of the DNA sequence. In this case, epigenetics controls how the animal’s genetic potential is used. The literature has shown that environmental modulation has a significant influence on the regulation of epigenetic mechanisms in poultry. The aim of this review is to give ...
Published in Genome
The three-dimensional (3D) organization of the genome is a crucial enabler of cell fate, identity, and function. In this review, we will focus on the emerging role of altered 3D genome organization in the etiology of disease, with a special emphasis on brain cancers. We discuss how different genetic alterations can converge to disrupt the epigenome...
Published in Biochemistry and cell biology = Biochimie et biologie cellulaire
Fetal alcohol spectrum disorder (FASD) is caused by prenatal exposure to ethanol and has been linked to neurodevelopmental impairments. Alcohol has the potential to alter some of the epigenetic components that play a critical role during development. Previous studies have provided evidence that prenatal exposure to ethanol results in abnormal epige...
L’exposition des enfants en bas âge à des perturbateurs thyroïdiens est fortement suspectée d’affecter leurs fonctions cognitives. Une exposition modérée (dose faible) pourrait, de même qu’une hypothyroïdie légère, entraîner des troubles cognitifs chroniques... Or, des données épidémiologiques récentes montrent un défaut de QI chez les enfants expo...
BACKGROUND: Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply allele-specific RNA-seq on isogenic B6D2F1 mice to assay imprinted genes in tissues from early embryonic tissues between E3.5 and E7.25 and in pluripotent cell lines to evaluate maintenance of imprin...