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Penagos-Puig, Andrés Furlan-Magaril, Mayra
Published in
Frontiers in Cell and Developmental Biology
Heterochromatin is a constituent of eukaryotic genomes with functions spanning from gene expression silencing to constraining DNA replication and repair. Inside the nucleus, heterochromatin segregates spatially from euchromatin and is localized preferentially toward the nuclear periphery and surrounding the nucleolus. Despite being an abundant nucl...
Sati, Satish Bonev, Boyan Szabo, Quentin Jost, Daniel Bensadoun, Paul Serra, Francois Loubiere, Vincent Papadopoulos, Giorgio Lucio Rivera-Mulia, Juan-Carlos Fritsch, Lauriane
...
Published in
Molecular Cell
Sati et al. studied 3D chromatin organization in different types of cellular senescence. They have identified DNMT1 and HMGA2-mediated changes in the structural organization of senescence-associated heterochromatin domains (SAHDs) and architecture-associated gene-expression changes as the key difference among different senescent systems.
