Kargapolova, Yulia Rehimi, Rizwan Kayserili, Hülya Brühl, Joanna Sofiadis, Konstantinos Zirkel, Anne Palikyras, Spiros Mizi, Athanasia Li, Yun Yigit, Gökhan
...
Published in
Nature Communications
Members of the CHD chromatin remodeler family are implicated in human pathologies, however CHD6 remained poorly studied. Here, the authors show that CHD6 binds to and regulates autophagy and stress response genes across cell types. They identify a clinical mutation that affects its ability to recruit cofactors, leading to impaired autophagy inducti...
Gibert, Jean-Michel Peronnet, Frédérique
Drosophila melanogaster has played a paramount role in epigenetics, the study of changesin gene function inherited through mitosis or meiosis that are not due to changes in the DNA sequence.By analyzing simple phenotypes, such as the bristle position or cuticle pigmentation, asread-outs of regulatory processes, the identification of mutated genes l...
zheng, wei tasselli, luisa tie-mei, li chua, katrin f.
The modulation of dynamic histone acetylation states is key for organizing chromatin structure and modulating gene expression and is regulated by histone acetyltransferase (HAT) and histone deacetylase (HDAC) enzymes. The mammalian SIRT6 protein, a member of the Class III HDAC Sirtuin family of NAD+-dependent enzymes, plays pivotal roles in aging, ...
Bansal, Kushagra Michelson, Daniel A Ramirez, Ricardo N Viny, Aaron D Levine, Ross L Benoist, Christophe Mathis, Diane
Published in
Proceedings of the National Academy of Sciences of the United States of America
Aire controls immunological tolerance by driving promiscuous expression of a large swath of the genome in medullary thymic epithelial cells (mTECs). Its molecular mechanism remains enigmatic. High-resolution chromosome-conformation capture (Hi-C) experiments on ex vivo mTECs revealed Aire to have a widespread impact on higher-order chromatin struct...
Bylino, Oleg V. Ibragimov, Airat N. Pravednikova, Anna E. Shidlovskii, Yulii V.
Published in
Frontiers in Genetics
A constellation of chromosome conformation capture methods (С-methods) are an important tool for biochemical analysis of the spatial interactions between DNA regions that are separated in the primary sequence. All these methods are based on the long sequence of basic steps of treating cells, nuclei, chromatin, and finally DNA, thus representing a s...
Khilji, Saadia Li, Yuan Chen, Jihong Li, Qiao
Published in
Frontiers in Pharmacology
Stem cells represent a key resource in regenerative medicine, however, there is a critical need for pharmacological modulators to promote efficient conversion of stem cells into a myogenic lineage. We have previously shown that bexarotene, an agonist of retinoid X receptor (RXR) approved for cancer therapy, promotes the specification and differenti...
kurbidaeva, amina purugganan, michael
The genomes of higher eukaryotes are partitioned into topologically associated domains or TADs, and insulators (also known as boundary elements) are the key elements responsible for their formation and maintenance. Insulators were first identified and extensively studied in Drosophila as well as mammalian genomes, and have also been described in ye...
Galloy, Maxime Lachance, Catherine Cheng, Xue Distéfano-Gagné, Félix Côté, Jacques Fradet-Turcotte, Amelie
Published in
Frontiers in Cell and Developmental Biology
The modification of histones—the structural components of chromatin—is a central topic in research efforts to understand the mechanisms regulating genome expression and stability. These modifications frequently occur through associations with multisubunit complexes, which contain active enzymes and additional components that orient their specificit...
Polajnar, Mercedes
Epigenetika, področje molekularne biologije, omogoča spreminjanje genetske informacije prek odziva organizma na okoljske signale brez spremembe zaporedja DNA molekule. Epigenetska regulacija je dosežena z različnimi epigenetski mehanizmi in povzroča značilno vklapljanje ter izklapljanje prepisovanja določenih genov. Najpogostejši rastlinski epigene...
Brumbaugh, Justin Di Stefano, Bruno Sardina, José Luis
Published in
Frontiers in Cell and Developmental Biology
