Leal Filho, Walter Nagy, Gustavo J Martinho, Filipe Saroar, Mustafa Erache, Mónica Gómez Primo, Ana Lígia Pardal, Miguel A Li, Chunlan
Published in
International journal of environmental research and public health
It is well-known that climate change significantly impacts ecosystems (at the macro-level) and individual species (at the micro-level). Among the former, estuaries are the most vulnerable and affected ecosystems. However, despite the strong relations between climate change and estuaries, there is a gap in the literature regarding international stud...
Ferreira, Chayanne Silva Vendramini, Thiago Henrique Annibale Amaral, Andressa Rodrigues Rentas, Mariana Fragoso Ernandes, Mariane Ceschin da Silva, Flavio Lopes Oba, Patricia Massae de Oliveira Roberti Filho, Fernando Brunetto, Marcio Antonio
Published in
BMC Veterinary Research
BackgroundObesity is one of the most common nutritional disorders in dogs and cats and is related to the development metabolic comorbidities. Weight loss is the recommended treatment, but success is difficult due to the poor satiety control. Yeast beta-glucans are known as biological modifiers because of their innumerable functions reported in stud...
Lee, Sol Ji Choi, Yu-Jeong Kim, Hyo In Moon, Hyo Eun Paek, Sun Ha Kim, Tai Young Ko, Seong-Gyu
Published in
Molecular oncology
Targeting autophagy is a promising therapeutic approach in cancer therapy. Here, we screened 30 traditional herbal medicines to identify novel autophagy regulators and found that Platycodon grandiflorus (PG) and platycodin D (PD), a triterpenoid saponin from PG, inhibited autophagy in glioblastoma multiforme (GBM) cells. Mechanistically, PD prevent...
Wang, Mei-Sa Han, Qiu-Shuang Jia, Zhi-Rong Chen, Chuan-Sheng Qiao, Chen Liu, Qian-Qian Zhang, Ya-Meng Wang, Kai-Wei Wang, Jie Xiao, Kang
...
Published in
Acta pharmacologica Sinica
Recent studies show that intracellular accumulation of cholesterol leads to acquired resistance to gefitinib in non-small cell lung cancer (NSCLC) cells. In this study we investigated how to regulate the cholesterol levels in gefitinib-resistant NSCLC cells. We showed that intracellular cholesterol levels in gefitinib-resistant cell lines (PC-9/GR,...
Chang, Ta Yuan Chang, Catherine C. Y. Harned, Taylor C. De La Torre, Adrianna L. Lee, Junghoon Huynh, Thao N. Gow, James G.
Published in
Exploration of Neuroprotective Therapy
Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions. Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), also named as sterol O-acyltransferase 1, is a membrane-bound enzyme residing at the endoplasmic reticulum (ER). It converts choles...
Jiang, Xuntian Ory, Daniel S.
Published in
Exploration of Neuroprotective Therapy
Niemann-Pick C disease is a rare neurodegenerative, lysosomal storage disease caused by accumulation of unesterified cholesterol. Diagnosis of the disease is often delayed due to its rarity, the heterogeneous presentation, and the early non-specific symptoms. The discovery of disease-specific biomarkers—cholestane-3β,5α,6β-triol (C-triol), trihydro...
Ye, Dien Yang, Xiaofei Ren, Liwei Lu, Hong S. Sun, Yuan Lin, Hui Tan, Lunbo Wang, Na Nguyen, Genevieve Bader, Michael
...
Published in
Frontiers in Cardiovascular Medicine
Objective: Elevated plasma cholesterol concentrations contributes to ischemic cardiovascular diseases. Recently, we showed that inhibiting hepatic (pro)renin receptor [(P)RR] attenuated diet-induced hypercholesterolemia and hypertriglyceridemia in low-density lipoprotein receptor (LDLR) deficient mice. The purpose of this study was to determine whe...
Sletner, Line Moen, Aina E. F. Yajnik, Chittaranjan S. Lekanova, Nadezhda Sommer, Christine Birkeland, Kåre I. Jenum, Anne K. Böttcher, Yvonne
Published in
Frontiers in Endocrinology
Background Leptin, mainly secreted by fat cells, plays a core role in the regulation of appetite and body weight, and has been proposed as a mediator of metabolic programming. During pregnancy leptin is also secreted by the placenta, as well as being a key regulatory cytokine for the development, homeostatic regulation and nutrient transport within...
Choi, Hong Y. Ruel, Isabelle Choi, Shiwon Genest, Jacques
Published in
Frontiers in Cardiovascular Medicine
The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways. To develop athero-protective therapies aimed at promoting macrophage cholesterol efflux, cholesterol metabolism in THP-1 monocyte-derived macrophages has been extensively studied, but the in...
Nakato, Mitsuhiro Shiranaga, Naoko Tomioka, Maiko Watanabe, Hitomi Kurisu, Junko Kengaku, Mineko Komura, Naoko Ando, Hiromune Kimura, Yasuhisa Kioka, Noriyuki
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Large transporter protein linked to schizophrenia. 京都大学プレスリリース. 2021-01-07. / ABCA13の異常によるコレステロール輸送障害が統合失調症を引き起こすことを解明. 京都大学プレスリリース. 2021-01-08. / ATP-binding cassette subfamily A member 13 (ABCA13) is predicted to be the largest ABC protein, consisting of 5, 058 amino acids and a long N-terminal region. Mutations in the ABCA13 gene were reported t...
