Oladeji, Deborah Olanrewaju, Ademidun Akinbola, Elizabeth
A six-week study was conducted to evaluate the effects of partial replacement of maize with Orange Fleshed Sweet Potato (OFSP) root meal on the haematological parameters and serum biochemistry of broiler chickens at finisher phase. One hundred and eight (108) day old broiler chicks were randomly allotted into 4 dietary treatments (T1, T2, T3 and T4...
Hong, Pingping Wang, Qing Chen, Guoping
Cholesterol stimulates inflammation and affects the normal function of islet tissues. However, the precise mechanism underlying the effects of cholesterol on islet cells requires clarification. In this study, we explored the role of cholesterol in glucose utilization in pancreatic cells. Beta-TC-6 cells and mice were treated with cholesterol. We us...
Katayama, Tomoka Chigi, Yuta Okamura, Daiji
Frontiers in Cell and Developmental Biology
To produce muscle fibers for cultured meat on a large scale, it is important to expand myoblasts in a serum-reduced or serum-free medium to avoid cost, ethical, and environmental issues. Myoblasts such as C2C12 cells differentiate quickly into myotubes and lose their ability to proliferate when the serum-rich medium is replaced with a serum-reduced...
Chang, Xiaole Zhao, Yongfang Qin, Shucun Wang, Hao Wang, Bingxiang Zhai, Lei Liu, Boyan Gu, Hong-mei Zhang, Da-wei
Frontiers in Cardiovascular Medicine
Wu, Haibin Xu, Jiang Sun, Jiarong Duan, Jian Xiao, Jinlin Ren, Quan Zhou, Pengfei Yan, Jian Li, Youping Xiong, Xiaoxing
Frontiers in Neurology
Objective The mechanisms underpinning Moyamoya disease (MMD) remain unclear, and effective biomarkers remain unknown. The purpose of this study was to identify novel serum biomarkers of MMD. Methods Serum samples were collected from 23 patients with MMD and 30 healthy controls (HCs). Serum proteins were identified using tandem tandem-mass-tag (TMT)...
de Jesus, Monica Raline Reis Santos, Thailine Santana Silva, Camilla Mendonça Zancanela, Vittor Tuzzi Costa, Patrícia Santos Oliveira Lima, João Vitor Ribeiro Júnior, Valdir Brito, Claudson Oliveira de Oliveira Júnior, Gregório Murilo
Journal of animal physiology and animal nutrition
This study was conducted to determine the metabolizable energy (ME) requirement for quails (Cortunix cortunix cortunix) from 28 to 42 days of age. Four hundred and twenty quails were distributed in a completely randomized design, with 5 treatments (2950, 3000, 3050, 3100 and 3150 kcal of ME/kg of feed), 7 replicates and 12 birds per experimental un...
Zheng, Qiang Han, Yinxiu Fan, Min Gao, Xinran Ma, Mengdie Xu, Jingxian Liu, Sen Ge, Jinfang
Experimental and therapeutic medicine
Triggering receptor expressed on myeloid cells 2 (TREM2) is an important member of the immunoglobulin family of inflammatory stimulating receptors and is involved in a number of pathophysiological processes. The present study aimed to investigate the role of TREM2 in neurotoxicity induced by high cholesterol levels in SH-SY5Y cells and explore the ...
Jin, Min Tao, Chao Hu, Xu Liu, Bangheng Ma, Cheng Wu, Zhonglian Yao, Hang Wang, Dong-An
Advanced healthcare materials
Due to the safety issue and poor underwater adhesion of current commercially available bioadhesives, they are hard to apply to in vivo physiological environments and more diverse medical use conditions. In this study, a novel and facile bioadhesive for underwater medical applications are designed based on the coacervation of electrostatic interacti...
Hazra, Rituparna Roy, Durba
Journal of biomolecular structure & dynamics
Self-assembly of cholesterol (CHL) is infamous for its diverse deleterious effects on human health. Clinical research over several decades indicates that a diet rich in CHL typically leads to arterial plaques, cataracts and gall stones among others. Carbohydrates like the β-glucans efficiently lower serum CHL, possibly by inhibiting CHL absorption ...
Jones, Laney K. Calvo, Evan M. Campbell-Salome, Gemme Walters, Nicole L. Brangan, Andrew Rodriguez, Gabriela Ahmed, Catherine D. Morgan, Kelly M. Gidding, Samuel S. Williams, Marc S.
Frontiers in Health Services
Introduction Familial hypercholesterolemia (FH) is a common inherited cholesterol disorder that, without early intervention, leads to premature cardiovascular disease. Multilevel strategies that target all components of FH care including identification, cascade testing, and management are needed to address gaps that exist in FH care. We utilized in...