Chen, Yan Jiang, Peng Tian, Feng Chen, Guangyu Peng, Tao Deng, Xiaoming Li, Zhonghu Huang, Den Zhu, Jin Zhen, Ping
...
Published in
Journal of investigative surgery : the official journal of the Academy of Surgical Research
Background and Objective: The preferred treatment for Cholangiocarcinoma (CCA) patients is surgery. Approximately, 35% of patients can undergo surgical resection in clinic. Biomarkers for CCA need to be identified for diagnosis, treatment, or prognosis prediction of this disease. Y-box binding protein-1 (YBOX-1) is highly correlated with tumor prog...
Rizzo, Alessandro Brandi, Giovanni
Published in
Expert review of gastroenterology & hepatology
Biliary tract cancer (BTC) is a heterogeneous group of aggressive malignancies comprising ampulla of Vater cancer, gallbladder cancer, extrahepatic cholangiocarcinoma, and intrahepatic cholangiocarcinoma; unfortunately, the incidence of distant and locoregional recurrence remains high in resected BTCs, with approximately 60-70% of patients which wi...
Di Federico, Alessandro Rizzo, Alessandro Ricci, Angela Dalia Frega, Giorgio Palloni, Andrea Tavolari, Simona Brandi, Giovanni
Published in
Expert opinion on investigational drugs
Biliary tract cancers (BTCs) include four uncommon primary biliary malignancies characterized by poor prognosis: intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, gallbladder cancer, and ampulla of Vater cancer. To date, the available therapeutic options are limited; nevertheless, with the advent of targeted therapy and immunotherap...
Lang, Qingfu Xiao, Peng Zhao, Ming Liang, Desen Meng, Qinghui Pei, Tiemin
Published in
Acta biochimica et biophysica Sinica
Intrahepatic cholangiocarcinoma (ICC) arises from cholangiocytes in the intrahepatic bile duct and is the second most common type of liver cancer. The overexpression of COUP-TFII has been observed in several types of malignancies. However, its role in ICC progression remains unclear. In this study, we found that the protein level of COUP-TFII was i...
Nakanuma, Yasuni Uesaka, Katsuhiko Kakuda, Yuko Sugino, Takashi Kubota, Keiichi Furukawa, Toru Fukumura, Yuki Isayama, Hiroyuki Terada, Takuro
Published in
Journal of clinical medicine
Intraductal papillary neoplasm of the bile duct (IPNB), a pre-invasive neoplasm of the bile duct, is being established pathologically as a precursor lesion of invasive cholangiocarcinoma (CCA), and at the time of surgical resection, approximately half of IPNBs show stromal invasion (IPNB associated with invasive carcinoma). IPNB can involve any par...
Tan, Elaine S Cao, Biwei Kim, Jongphil Al-Toubah, Taymeyah E Mehta, Rutika Centeno, Barbara A Kim, Richard D
Published in
Cancer
Biliary tract cancer (BTC) has a poor prognosis despite treatment with first-line gemcitabine and cisplatin. In BTC, PI3K/AKT pathway activation has been shown to increase resistance to chemotherapy, which may be overcome with PI3K inhibition. This phase 2 study evaluated the safety and efficacy of copanlisib, a PI3K inhibitor, with gemcitabine and...
Intuyod, Kitti Chomwong, Sasitorn Thongpon, Phonpilas Vaeteewoottacharn, Kulthida Pairojkul, Chawalit Pinlaor, Porntip Pinlaor, Somchai
Published in
Anticancer research
Forkhead box O4 (FOXO4) has been demonstrated to be a tumor suppressor and proposed as target for treatment of a variety of cancer types. However, the role of FOXO4 in cholangiocarcinoma (CCA), a dangerous cancer of bile-duct epithelium, has rarely been explored. The proliferative rate of CCA cell lines KKU-213B, KKU-055 and KKK-D068 was investigat...
Zhai, Xiangyu Wang, Wei Ma, Yunlong Zeng, Yijia Dou, Dandan Fan, Haoning Song, Jianping Yu, Xin Xin, Danqing Du, Gang
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Published in
Aging
Cell proliferation and migration are the determinants of malignant tumor progression, and a better understanding of related genes will lead to the identification of new targets aimed at preventing the spread of cancer. Some studies have shown that KIAA1199 (CEMIP) is a transmembrane protein expressed in many types of noncancerous cells and cancer c...
Loeffler, Moritz A Hu, Jun Kirchner, Martina Wei, Xiyang Xiao, Yi Albrecht, Thomas De La Torre, Carolina Sticht, Carsten Banales, Jesus M Vogel, Monika N
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Published in
The Journal of pathology
Distal cholangiocarcinoma (dCCA) is a biliary tract cancer with a dismal prognosis and is often preceded by biliary intraepithelial neoplasia (BilIN), representing the most common biliary non-invasive precursor lesion. BilIN are histologically well defined but have not so far been characterised systematically at the molecular level. The aim of this...
Xiong, Jianping Wang, Yaqin Xu, Weiyu Liu, Zhisong Wang, Haochen Zhang, Zhiyuan Han, Yanjing Yin, Chao Cao, Shasha Yang, Zheran
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Published in
Liver international : official journal of the International Association for the Study of the Liver
Proton pump inhibitors (PPIs) have been reported to be associated with cholangitis and might possibly be carcinogenic. However, few studies have been conducted to investigate the association of PPIs with cholangiocarcinoma (CCA). Thus, a hospital-based case-control study was carried out in China to explore the association between PPIs and CCA. In t...
