Gould, Stacey
Programmed axon degeneration (Wallerian degeneration) can occur after physical injury, inhibition of axon transport, exposure to neurotoxic compounds, and in diseases involving mitochondrial or metabolic dysfunction. There is increasing evidence that this pathway can be activated in human painful neuropathies and preclinical evidence suggests it is...
Rehman, Sumaiyah K Haynes, Jennifer Collignon, Evelyne Brown, Kevin R Wang, Yadong Nixon, Allison M L Bruce, Jeffrey P Wintersinger, Jeffrey A Singh Mer, Arvind Lo, Edwyn B L
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Published in
Cell
Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important drivers of therapy failure and tumor relapse. We combined cellular barcoding and mathematical modeling in patient-derived colorectal cancer models to identify and characteri...
Ježek, Jan Cooper, Katrina F. Strich, Randy
Cancer is one of the world’s deadliest afflictions. Despite recent advances in diagnostic and surgical technologies, as well as improved treatments of some individual tumor types, there is currently no universal cure to prevent or impede the uncontrolled proliferation of malignant cells. Targeting tumors by inducing apoptosis is one of the pillars ...
Rallis, Kathrine S Lai Yau, Thomas Ho Sideris, Michail
Published in
Anticancer research
Chemoradiotherapy (CRT) refers to the combined administration of both chemotherapy and radiotherapy as an anticancer treatment. Over the years, CRT has become an established treatment for a diverse range of locally advanced solid tumours. The rationale for CRT is based on the two concepts of spatial cooperation and in-field cooperation, whereby the...
Kappenberg-Niţescu, Diana Cristala Luchian, Ionut Mârțu, Ioana Solomon, Sorina-Mihaela Mârţu, Silvia Păsărin, Liliana Mârțu, Alexandra Sioustis, Ioana-Andreea Goriuc, Ancuța Tatarciuc, Monica
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Published in
Experimental and therapeutic medicine
Chemotherapy often presents side effects, including oral adverse effects that may interfere with the completion of the oncology treatment, threatening the outcome of the treatment and significantly affecting the quality of life of the patient. The aim of the present study was to evaluate two antiseptic, antimicrobial and antifungal substances that ...
Săftescu, Sorin Popovici, Dorel Oprean, Cristina Negru, Alina Haiduc, Anita Stanca, Simona Malița, Daniel-Claudiu Volovăț, Simona Negru, Șerban
Published in
Experimental and therapeutic medicine
Cisplatin remains one of the most active antineoplastic treatments used in oncology, being the most prestigious exponent of the golden age in chemotherapy at the end of the 20th century. This chemotherapeutic drug is used for curative or palliative treatments in testicular, ovarian, head and neck neoplasms, sarcomas and lymphomas. The limiting dose...
Gradalski, Tomasz
Published in
Journal of palliative medicine
Background: Although decongestive physiotherapy combined with diuretics may be efficient in limb edemas, no such therapy has been described in the context of anasarca. Case Description: A bedbound 62-year-old man with stage IV pancreatic cancer, presenting with progressing severe dyspnea at rest and anasarca, was admitted to the free-standing hospi...
Aoki, Hideki Utsumi, Masashi Kimura, Yuji Takahashi, Yosuke Nagahisa, Seiichi Nishimura, Seitaro Une, Yuta Watanabe, Megumi Taniguchi, Fumitaka Arata, Takashi
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Cardiac metastasis originating from hepatocellular carcinoma (HCC) is a rare condition with a poor prognosis. No therapeutic standards for cardiac metastasis originating from HCC have been established. At 19 months after a curative hepatectomy, a 64-year-old Japanese hepatitis B virus-positive male patient experienced solitary cardiac metastasis or...
Sarkis, J Assaf, J
Published in
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Immunotherapy is gradually revolutionizing bladder cancer treatment. In this extensive review published by Hanna et al. in your journal, the authors presented recent studies that are trying to challenge the standard platinum-based chemotherapy as first-line treatment of metastatic bladder cancer by chemoimmunotherapy. However, upfront pembrolizumab...
Daniel, Davey Kuchava, Vladimer Bondarenko, Igor Ivashchuk, Oleksandr Reddy, Sreekanth Jaal, Jana Kudaba, Iveta Hart, Lowell Matitashvili, Amiran Pritchett, Yili
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Published in
International journal of cancer
Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were evaluated in a randomised, doub...