Fouquet, Helen Giovannelli, Jonathan de Nadaï, Patricia Balsamelli, Joanne Berger, Patrick Bourdin, Arnaud Chanez, Pascal Fry, Stéphanie Perez, Thierry Magnan, Antoine
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Published in
The Journal of asthma : official journal of the Association for the Care of Asthma
This exploratory cross-sectional study aimed to evaluate the associations between the chemokine ligand 18 (CCL18) blood level and phenotypic characteristics of asthma. In a sample of 173 asthmatic adult patients from the Cohort of Bronchial obstruction and Asthma (63.4% women; median age 50 ± interquartile range 27.5 years; median level of CCL18 wa...
Zuo, Tongkun Tang, Qing Zhang, Xiangcheng Shang, Futai
Published in
Molecular therapy. Nucleic acids
Mitochondrial dysfunction and chemokine production have been reported to be involved in the pathogenesis of sepsis. Our initial bioinformatics analysis identified differentially expressed TLR2 in sepsis and the upstream regulatory microRNA-410-3p (miR-410-3p). Hence, the current study was performed to characterize the potential mechanism by which m...
Ahmed, Azaz Halama, Niels
Published in
Anticancer research
Chemokine receptor inhibition is an immunotherapy that modulates the innate arm of the immune system. Previous work in microsatellite-stable metastatic colorectal cancer showed an exploitive loop that could be successfully targeted via C-C-motive-chemokine-receptor 5 (CCR5) specific blocking, resulting in a selective anti-tumoral activation of macr...
Park, Inyoung Son, Myoungsun Ahn, Eunseon Kim, Young-Woong Kong, Young-Yun Yun, Yungdae
Published in
Molecules and cells
Lck-interacting transmembrane adaptor 1 (LIME) has been previously identified as a raft-associated transmembrane protein expressed predominantly in T and B lymphocytes. Although LIME is shown to transduce the immunoreceptor signaling and immunological synapse formation via its tyrosine phosphorylation by Lck, a Src-family kinase, the in vivo functi...
Gascon, Suzanne Giraldo Solano, Angéla El Kheir, Wiam Therriault, Hélène Berthelin, Pierre Cattier, Bettina Marcos, Bernard Virgilio, Nick Paquette, Benoit Faucheux, Nathalie
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Published in
Pharmaceutics
The authors wish to make the following correction to this paper [...].
Sakai, Shunsuke Hatabu, Toshimitsu Yamamoto, Yuki Kimura, Koji
After parturition, cows frequently develop uterine bacterial infections, resulting in the onset of endometritis. To eliminate the bacteria, bovine endometrial cells secrete chemokines, such as IL-6 and MCP1, which attract macrophages (M Phi s) to the subepithelial stroma. These attracted M Phi s are not only involved in bacterial elimination but al...
Goto, Taichi Sapio, Matthew R Maric, Dragan Robinson, Jeffrey M Saligan, Leorey N Mannes, Andrew J Iadarola, Michael J
Published in
The journal of pain : official journal of the American Pain Society
Pain is a common but potentially debilitating symptom, often requiring complex management strategies. To understand the molecular dynamics of peripheral inflammation and nociceptive pain, we investigated longitudinal changes in behavior, tissue structure, and transcriptomic profiles in the rat carrageenan-induced peripheral inflammation model. Sequ...
Grassin-Delyle, Stanislas Salvator, Hélène Brollo, Marion Catherinot, Emilie Sage, Edouard Couderc, Louis-Jean Naline, Emmanuel Devillier, Philippe
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 µM) inhibited the lipopolysaccharide-induced release of TNF-ɑ (by 76%), IL-6 (by 68%), CCL2 (by 72%), and CCL3 (by 67%). Besides its antiviral activity, chloroquine might also mitigate the cytokine storm associated with severe pneumonia caused by co...
Logerot, Sandrine Figueiredo-Morgado, Suzanne Charmeteau-de-Muylder, Bénédicte Sandouk, Abdelkader Drillet-Dangeard, Anne-Sophie Bomsel, Morgane Bourgault-Villada, Isabelle Couëdel-Courteille, Anne Cheynier, Rémi Rancez, Magali
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Hou, Wanting Liu, Ruiqi Bi, Siwei He, Qian Wang, Haibo Gu, Jun
Published in
Molecules (Basel, Switzerland)
Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hyd...
