Wen, Qiuting Muskat, Joseph Babbs, Charles F Wright, Adam M Zhao, Yi Zhou, Xiaopeng Zhu, Chengcheng Tong, Yunjie Wu, Yu-Chien Risacher, Shannon L
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Published in
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Intracranial cardiac impulse propagation along penetrating arterioles is vital for both nutrient supply via blood circulation and waste clearance via CSF circulation. However, current neuroimaging methods are limited to simultaneously detecting impulse propagation at pial arteries, arterioles, and between them. We hypothesized that this propagation...
george, nimisha pradeep kwon, minjun jang, yong eun kim, seok hwang, ji su lee, sang seop lee, gwang
Multiple system atrophy (MSA) is a progressive neurodegenerative synucleinopathy. Differentiating MSA from other synucleinopathies, especially in the early stages, is challenging because of its overlapping symptoms with other forms of Parkinsonism. Thus, there is a pressing need to clarify the underlying biological mechanisms and identify specific ...
candeloro, raffaella ferri, caterina laudisi, michele baldi, eleonora pugliatti, maura castellazzi, massimiliano
Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Oligoclonal bands (OCBs) in cerebrospinal fluid (CSF) are a hallmark of MS and reflect intrathecal IgG synthesis and inflammation. This study aims to analyze the temporal distribution of IgG OCBs in the CSF of patients with a definitive diagno...
kelly, sophie h. nightingale, sam gupta, ravindra k. collier, dami a.
Neurocognitive impairment is an important cause of HIV-associated morbidity. The advent of antiretroviral therapy (ART) has shifted the spectrum of HIV-associated cognitive impairment from HIV-associated dementia to milder forms of cognitive impairment. Independent replication of HIV within the central nervous system in those on effective ART with ...
mughal, zahir martinez-devesa, pablo boukas, alexandros jeyaretna, sanjeeva qureishi, ali
Background/Objectives: Cerebrospinal fluid (CSF) rhinorrhoea carries a significant risk of life-threatening intracranial complications. This review provides a contemporary overview of current management strategies for CSF rhinorrhoea. Methods: We conducted a literature review, examining studies from Medline, Embase, and Google Scholar published wit...
seyfried, katharina sophie kremer, benedikt conzen-dilger, catharina veldeman, michael bertram, ulf blume, christian mueller, christian andreas tianshu, bi jütten, kerstin clusmann, hans
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Despite extensive research on aneurysm treatment and neurocritical care, aneurysmal subarachnoid hemorrhage (SAH) is still a life-threatening disease, often leaving survivors with lasting neurological and cognitive impairments. Early brain injury (EBI) and delayed cerebral ischemia (DCI) are the main contributors to brain damage, with neuroinflamma...
trojan, gabriela moniuszko-malinowska, anna orywal, karolina kruszewska, ewelina mroczko, barbara grzeszczuk, anna czupryna, piotr
Introduction: Calcium homeostasis is essential for neurophysiological functions, with dysregulation implicated in neurodegenerative diseases. Recent studies suggest that specific viral brain infections, such as tick-borne encephalitis, can initiate neuronal loss and subsequent neurodegenerative changes. This study examines alterations in calcium le...
baraniuk, james n.
Post-exertional malaise (PEM) is a defining condition of myalgic encephalomyelitis (ME/CFS). The concept requires that a provocation causes disabling limitation of cognitive and functional effort (“fatigue”) that does not respond to rest. Cerebrospinal fluid was examined as a proxy for brain metabolite and lipid flux and to provide objective eviden...
Hannich, Malte J. Konen, Franz F. Gag, Konrad Alkhayer, Aiham Türker, Seda N. Budde, Kathrin Nauck, Matthias Wurster, Ulrich Dressel, Alexander Skripuletz, Thomas
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Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Objectives Oligoclonal bands (OCB) analysis is the reference standard for detecting an intrathecal IgG synthesis. Alongside OCB, free light chains kappa (FLCκ) are considered an additional sensitive biomarker for determining patterns 2 or 3, indicating intrathecal Ig synthesis. However, kFLC IF is not suitable for detecting a monoclonal pattern 5. ...
Courtney, Ya'el Hochstetler, Alexandra Lehtinen, Maria K.
This review examines the roles of the choroid plexus (ChP) in central nervous system (CNS) pathology, emphasizing its involvement in disease mechanisms and therapeutic potential. Structural changes in the human ChP have been reported across various diseases in case reports and descriptive work, but studies have yet to pin down the physiological rel...