New basic and translational perspectives on skin repair
Published in Frontiers in Physiology
New basic and translational perspectives on skin repair
Oxysterol Sensing Through GPR183 Triggers Endothelial Senescence in Hypertension.
...Published in Circulation research
Despite endothelial dysfunction being an initial step in the development of hypertension and associated cardiovascular/renal injuries, effective therapeutic strategies to prevent endothelial dysfunction are still lacking. GPR183 (G protein-coupled receptor 183), a recently identified G protein-coupled receptor for oxysterols and hydroxylated metabo...
Identification of cellular senescence-related genes and immune cell infiltration characteristics in intervertebral disc ...
Published in Frontiers in Immunology
Background Intervertebral disc degeneration (IDD) progression involves multiple factors, including loss of nucleus pulposus cells and extracellular matrix as the basic pathological mechanism of degeneration, and is closely related to cellular senescence and immune cell infiltration. The aim of study was to identify critical cellular senescence-rela...
Prognostic cellular senescence-related lncRNAs patterns to predict clinical outcome and immune response in colon cancer
Published in Frontiers in Immunology
Background Cellular senescence (CS) is believed to be a major factor in the evolution of cancer. However, CS-related lncRNAs (CSRLs) involved in colon cancer regulation are not fully understood. Our goal was to create a novel CSRLs prognostic model for predicting prognosis and immunotherapy and exploring its potential molecular function in colon ca...
Systematic transcriptomic analysis and temporal modelling of human fibroblast senescence
Published in Frontiers in Aging
Cellular senescence is a diverse phenotype characterised by permanent cell cycle arrest and an associated secretory phenotype (SASP) which includes inflammatory cytokines. Typically, senescent cells are removed by the immune system, but this process becomes dysregulated with age causing senescent cells to accumulate and induce chronic inflammatory ...
Exploring the molecular and immune landscape of cellular senescence in lung adenocarcinoma
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Published in Frontiers in Immunology
Introduction The connection between aging and cancer is complex. Previous research has highlighted the association between the aging process of lung adenocarcinoma (LUAD) cells and the immune response, yet there remains a gap in confirming this through single-cell data validation. Here, we aim to develop a novel aging-related prognostic model for L...
Exploring senescence as a modifier of β cell extracellular vesicles in type 1 diabetes
Published in Frontiers in Endocrinology
Type 1 Diabetes (T1D) is a chronic metabolic disease resulting from insulin deficiency due to autoimmune loss of pancreatic β cells. In addition to β cell destruction, it is now accepted that β cell stress and dysfunction, such as senescence, plays a crucial role in the development of the disease. Accumulation of senescent β cells occurs during dev...
Investigation of differentially expressed genes related to cellular senescence between high-risk and non-high-risk group...
Published in Frontiers in Cell and Developmental Biology
Object This study aims to identify differentially expressed genes (DEGs) between high-risk and non-high-risk groups in neuroblastoma (NB), construct a prognostic model, and establish a risk score formula. Materials and methods The NB dataset GSE49710 (n = 498) from the GEO database served as the training cohort to select DEGs between high-risk and ...
The effects of cGAS-STING inhibition in liver disease, kidney disease, and cellular senescence
Published in Frontiers in Immunology
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is one of the fundamental mechanisms of the body’s defense, which responds to the abnormal presence of double-stranded DNA in the cytoplasm to establish an effective natural immune response. In addition to detecting microbial infections, the cGAS pathway may...
Wogonin protects against bleomycin-induced mouse pulmonary fibrosis via the inhibition of CDK9/p53-mediated cell senesce...
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Published in Frontiers in Pharmacology
Pulmonary fibrosis (PF) is a fatal interstitial lung disease associated with declining pulmonary function but currently with few effective drugs. Cellular senescence has been implicated in the pathogenesis of PF and could be a potential therapeutic target. Emerging evidence suggests wogonin, the bioactive compound isolated from Scutellaria baicalen...
