Seidel, Markus G. Kashofer, Karl Moser, Tina Thueringer, Andrea Liegl-Atzwanger, Bernadette Leithner, Andreas Szkandera, Joanna Benesch, Martin El-Heliebi, Amin Heitzer, Ellen
...
Published in
Frontiers in Pediatrics
Background Treatment stratification and response assessment in pediatric sarcomas has relied on imaging studies and surgical/histopathological evidence of vital tumor cells. Such studies and evidence collection processes often involve radiation and/or general anesthesia in children. Cell-free circulating tumor DNA (ctDNA) detection in blood plasma ...
Okada, Toshio Muto, Eisuke Yamanaka, Tsuyoshi Uchino, Hiroyuki Inazu, Masato
Published in
International journal of molecular sciences
Microglia are key cells of the immune system in the central nervous system and are suggested to be deeply involved in the development of neurodegenerative diseases. It is well known that microglia have functional plasticity, with an inflammatory M1 phenotype and an anti-inflammatory M2 phenotype. Inhibition of choline transport in macrophages has b...
Dar, Pe'er Jacobsson, Bo Clifton, Rebecca Egbert, Melissa Malone, Fergal Wapner, Ronald J Roman, Ashley S Khalil, Asma Faro, Revital Madankumar, Rajeevi
...
Published in
American journal of obstetrics and gynecology
Historically, prenatal screening has focused primarily on the detection of fetal aneuploidies. Cell-free DNA now enables noninvasive screening for subchromosomal copy number variants, including 22q11.2 deletion syndrome (or DiGeorge syndrome), which is the most common microdeletion and a leading cause of congenital heart defects and neurodevelopmen...
Gale, D Heider, K Ruiz-Valdepenas, A Hackinger, S Perry, M Marsico, G Rundell, V Wulff, J Sharma, G Knock, H
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Published in
Annals of oncology : official journal of the European Society for Medical Oncology
Identification of residual disease in patients with localized non-small cell lung cancer (NSCLC) following treatment with curative intent holds promise to identify patients at risk of relapse. New methods can detect circulating tumour DNA (ctDNA) in plasma to fractional concentrations as low as a few parts per million, and clinical evidence is requ...
boldrin;, elisa
Anti-HER2 monoclonal antibody trastuzumab improves the survival of those patients with advanced gastroesophageal adenocarcinoma (GEA) exhibiting HER2/ERBB2 overexpression/amplification. The current gold standard methods used to diagnose the HER2 status in GEA are immunohistochemistry (IHC) and silver or fluorescence in situ hybridization (SISH or F...
lee;, taehee
(1) Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Although various serum enzymes have been utilized for the diagnosis and prognosis of HCC, the currently available biomarkers lack the sensitivity needed to detect HCC at early stages and accurately predict treatment responses. (2) Methods:...
werner;, bonnita
Cell-free DNA (cfDNA) is a useful molecular biomarker in oncology research and treatment, but while research into its properties in blood has flourished, there remains much to be discovered about cfDNA in other body fluids. The cfDNA from saliva, sputum, cerebrospinal fluid, urine, faeces, pleural effusions, and ascites has unique advantages over b...
mascha binder, lisa paschold;
Tumor cells shed DNA into the plasma. “Liquid biopsy” analysis of mutations or other genomic alterations in circulating cell-free DNA (cfDNA) may provide us with a tool to detect minimal residual cancer, comprehensively profile the genomic tumor landscape in search of druggable targets, and monitor cancers non-invasively over time for treatment fai...
Pisapia, Pasquale Pepe, Francesco Gristina, Valerio La Mantia, Maria Francomano, Vincenzo Russo, Gianluca Iaccarino, Antonino Galvano, Antonio
Published in
Mediastinum
Objective In this review, we evaluate the role of liquid biopsy in managing lung cancer patients during the still ongoing coronavirus disease 2019 (COVID-19) healthcare emergency. Background The novel influenza coronavirus (severe acute respiratory syndrome coronavirus or SARS-CoV-2) has upended several aspects of our lives, including medical activ...
koulouris;, andreas
Metastatic colorectal cancer (mCRC) remains a highly lethal malignancy, although considerable progress has resulted from molecular alterations in guiding optimal use of available treatments. CRC recurrence remains a great barrier in the disease management. Hence, the spotlight turns to newly mapped fields concerning recurrence risk factors in patie...
