Srčno–žilne bolezni so v razvitem delu sveta in tudi v Sloveniji že desetletja najpogostejši vzrok obolevnosti in umrljivosti odraslih. Če je ob srčnem infarktu pretok krvi prekinjen dlje kot 20-30 minut, so posledice ireverzibilne, saj srčne celice odmrejo. Naravno prisotna regenerativna sposobnost človekovega srčnega mišičnega tkiva je bistveno p...
Published in Tissue engineering. Part A
Osteonecrosis of the femoral head (ONFH) is defined as a tissue disorder and successive subchondral bone collapse resulting from an ischemic process, which may progress to hip osteoarthritis. Cell therapy with multipotent bone marrow mesenchymal stromal cells (BM-MSC) of autologous origin appears to be safe and has shown regenerative potential in p...
Terapija z modificiranimi limfociti T (CAR-T) je ena najsodobnejših oblik imunoterapije za zdravljenja raka. Temelji na genetsko spremenjenih, pacientu avtolognih celicah T, ki na svoji površini izražajo himerni antigenski receptor (ang. chimeric antigen receptor ali CAR). Ta je sposoben prepoznati tumorske antigene in sprožiti imunski odziv preko ...
Published in International journal of molecular sciences
Stroke remains a major cause of serious disability because the brain has a limited capacity to regenerate. In the last two decades, therapies for stroke have dramatically changed. However, half of the patients cannot achieve functional independence after treatment. Presently, cell-based therapies are being investigated to improve functional outcome...
Published in Journal of wound care
The limited amount of donor sites and loss of dermis are major challenges in the therapy of extensively burned patients. Here, we present a complex treatment approach of an eight-year-old boy with full-thickness burns on 90% of the total body surface area, using simple and efficient techniques of tissue engineering. To obtain sufficient skin for gr...
Cytokine-inducible SH2-containing protein (CIS; encoded by the gene CISH) is a key negative regulator of interleukin-15 (IL-15) signaling in natural killer (NK) cells. Here, we develop human CISH-knockout (CISH-/-) NK cells using an induced pluripotent stem cell-derived NK cell (iPSC-NK cell) platform. CISH-/- iPSC-NK cells demonstrate increased IL...
Published in Journal of Biosciences
AbstractThe idea of regenerating lost myocardium via cell-based therapies remains as highly considerable. C-kit+ stem/progenitor cells are represented to be suitable candidates for cardiac regeneration compared to other stem cells. A multitude of cytokines from these cells are known to give such multifunctional properties; however, the associated m...
Published in Acta Medica Bulgarica
Gastric cancer (GC) is suitable for immunotherapy because 80% of it display microsatellite and chromosomal instability, some mutations and DNA hypermethylation. Therefore, GC is more immunogenic. The immunotherapy with monoclonal antibodies, adoptive cell therapy and checkpoint inhibition are discussed. The commonly used monoclonal antibodies are T...
Published in Frontiers in Immunology
The prominent role of dendritic cells (DC) in promoting tolerance and the development of methods to generate clinical grade products allowed the clinical application of tolerogenic DC (tolDC)-based therapies for controlling unwanted immune responses. We established an efficient method to generate tolerogenic human DC, producing supra-physiological ...
Published in Frontiers in Bioengineering and Biotechnology
Despite the advent of advanced therapy medicinal products (ATMPs) in regenerative medicine, gene therapy, cell therapies, tissue engineering, and immunotherapy, the availability of treatment is limited to patients close to state-of-the-art facilities. The SCORPIO-V Division of HNu Photonics has developed the Phoenix-Live Cell TransportTM, a battery...
