Quarta, Alessandra Berneman, Zwi Ponsaerts, Peter
Published in
Journal of leukocyte biology
Neuroinflammation is recognized as an important factor contributing to the development and progression of several central nervous system (CNS) disorders. Upon CNS trauma or disease, parenchymal microglia highly proliferate and accumulate in and around the lesion site. In addition, blood-derived monocytes can infiltrate the inflamed CNS in response ...
Mavrič, Anja
Aasen, Davis M Vergara, M Natalia
Published in
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Retinal disease represents a growing global problem, both in terms of quality of life and economic impact, yet new therapies are not being developed at a sufficient rate to meet this mounting need. In this context, retinal organoids derived from human induced pluripotent stem cells hold significant promise for improving upon the current drug develo...
Shridhar, Arthi Amsden, Brian G. Gillies, Elizabeth R. Flynn, Lauren E.
Published in
Frontiers in Bioengineering and Biotechnology
While it has been postulated that tissue-specific bioscaffolds derived from the extracellular matrix (ECM) can direct stem cell differentiation, systematic comparisons of multiple ECM sources are needed to more fully assess the benefits of incorporating tissue-specific ECM in stem cell culture and delivery platforms. To probe the effects of ECM sou...
Hirsch, Cordula Schildknecht, Stefan
Published in
Frontiers in Pharmacology
Concern regarding the reproducibility of observations in life science research has emerged in recent years, particularly in view of unfavorable experiences with preclinical in vivo research. The use of cell-based systems has increasingly replaced in vivo research and the application of in vitro models enjoys an ever-growing popularity. To avoid rep...
Malek, Goldis Busik, Julia Grant, Maria B Choudhary, Mayur
Published in
Expert opinion on drug discovery
The impact of vision debilitating diseases is a global public health concern, which will continue until effective preventative and management protocols are developed. Two retinal diseases responsible for the majority of vision loss in the working age adults and elderly populations are diabetic retinopathy (DR) and age-related macular degeneration (...
Togtema, Melissa Jackson, Robert Grochowski, Jessica Villa, Peter L Mellerup, Miranda Chattopadhyaya, Jyoti Zehbe, Ingeborg
Published in
Nanomedicine (London, England)
High-risk human papillomaviruses infect skin and mucosa, causing approximately 5% of cancers worldwide. In the search for targeted nanotherapeutic approaches, siRNAs against the viral E6 transcript have been molecules of interest but have not yet seen successful translation into the clinic. By reviewing the past approximately 15 years of in vitro l...
Christoffersson, Jonas
Organs-on-chips are dynamic cell culture devices created with the intention to mimic organ function in vitro. Their purpose is to assess the toxicity and efficacy of drugs and, as early as possible in the pharmaceutical development process, predict the outcome of clinical trials. The aim of this thesis is to explain and discuss these cell culture d...
Laude, Hubert Vilette, Didier Le Dur, Annick Archer, Fabienne Soulier, Solange Besnard, Nathalie Essalmani, Rachid Vilotte, Jean-Luc
Published in
Comptes rendus biologies
Sheep scrapie is a prototypical transmissible spongiform encephalopathy (TSE), and the most widespread of these diseases. Experimental study of TSE infectious agents from sheep and other species essentially depends on bioassays in rodents. Transmission of natural sheep scrapie to conventional mice commonly requires one or two years. In an effort to...
