Nakatani, Kazuma Kogashi, Hiroyuki Miyamoto, Takanori Setoguchi, Taiki Sakuma, Tetsushi Kugou, Kazuto Hasegawa, Yoshinori Yamamoto, Takashi Hippo, Yoshitaka Suenaga, Yusuke
...
Published in
Frontiers in Oncology
Amplification of MYCN is observed in high-risk neuroblastomas (NBs) and is associated with a poor prognosis. MYCN expression is directly regulated by multiple transcription factors, including OCT4, MYCN, CTCF, and p53 in NB. Our previous study showed that inhibition of p53 binding at the MYCN locus induces NB cell death. However, it remains unclear...
amason, megan e. lupeng, li harvest, carissa k. lacey, carolyn a. miao, edward a.
Caspases are a family of proteins involved in cell death. Although several caspase members have been well characterized, caspase-2 remains enigmatic. Caspase-2 has been implicated in several phenotypes, but there has been no consensus in the field about its upstream activating signals or its downstream protein targets. In addition, the unique abili...
Volik, Pavel I Kopeina, Gelina S Zhivotovsky, Boris Zamaraev, Alexey V
Published in
Trends in molecular medicine
The PIDDosome is a multiprotein complex that includes p53-induced protein with a death domain 1 (PIDD1), receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD), and caspase-2, the activation of which is driven by PIDDosome assembly. In addition to the key role of the PIDDosome in the regulation of cell di...
Pockes, Steffen Walters, Michael A Ashe, Karen H
Published in
Translational research : the journal of laboratory and clinical medicine
Targeting amyloid-β plaques and tau tangles has failed to provide effective treatments for Alzheimer's disease and related dementias (ADRD). A more fruitful pathway to ADRD therapeutics may be the development of therapies that target common signaling pathways that disrupt synaptic connections and impede communication between neurons. In this review...
Kim, Ju Youn Wang, Lily Q Sladky, Valentina C Oh, Tae Gyu Liu, Junlai Trinh, Kaitlyn Eichin, Felix Downes, Michael Hosseini, Mojgan Jacotot, Etienne D
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Published in
Cell metabolism
Sterol deficiency triggers SCAP-mediated SREBP activation, whereas hypernutrition together with ER stress activates SREBP1/2 via caspase-2. Whether these pathways interact and how they are selectively activated by different dietary cues are unknown. Here, we reveal regulatory crosstalk between the two pathways that controls the transition from hepa...
Bresinsky, Merlin Strasser, Jessica M Hubmann, Alexander Vallaster, Bernadette McCue, William M Fuller, Jessica Singh, Gurpreet Nelson, Kathryn M Cuellar, Matthew E Finzel, Barry C
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Published in
Archiv der Pharmazie
Since the discovery of the caspase-2 (Casp2)-mediated ∆tau314 cleavage product and its associated impact on tauopathies such as Alzheimer's disease, the design of selective Casp2 inhibitors has become a focus in medicinal chemistry research. In the search for new lead structures with respect to Casp2 selectivity and drug-likeness, we have taken an ...
köppl;, christoph
Fusion protein technologies to facilitate soluble expression, detection, or subsequent affinity purification in Escherichia coli are widely used but may also be associated with negative consequences. Although commonly employed solubility tags have a positive influence on titers, their large molecular mass inherently results in stochiometric losses ...
Kopeina, Gelina S Zhivotovsky, Boris
Published in
Trends in cell biology
Genomic instability underlies genesis and the development of various types of cancer. During tumorigenesis, cancer initiating cells assume a set of features, which allow them to survive and proliferate. Different mutations and chromosomal alterations promote a selection of the most aggressive cancer clones that worsen the prognosis of the disease. ...
Chai, Wei-Na Wu, Yi-Fan Wu, Zhi-Min Xie, Yan-Feng Shi, Quan-Hong Dan, Wei Zhan, Yan Zhong, Jian-Jun Tang, Wei Sun, Xiao-Chuan
...
Published in
Neural Regeneration Research
Studies have shown that downregulation of nuclear-enriched autosomal transcript 1 (Neat1) may adversely affect the recovery of nerve function and the increased loss of hippocampal neurons in mice. Whether Neat1 has protective or inhibitory effects on neuronal cell apoptosis after secondary brain injury remains unclear. Therefore, the effects of Nea...
Wang, Bei Zhang, Chongyang Yu, Congci Zhu, Yue Tang, Qing Huang, He Zhao, Zhendong
Published in
Frontiers in Microbiology
Enterovirus 71 (EV71) is the major causative pathogen of hand, foot, and mouth disease. The lack of understanding of the virus’s pathogenesis hinders the development of anti-virus drugs and the control of EV71 infection. Our previous studies have demonstrated that both mitochondria and endoplasmic reticulum (ER) were altered significantly in EV71 i...
