Guan, Liying Voora, Deepak Myers, Rachel Del Carpio-Cano, Fabiola Rao, A Koneti
Published in
Journal of thrombosis and haemostasis : JTH
Hematopoietic transcription factor RUNX1 is expressed from proximal P2 and distal P1 promoters to yield isoforms RUNX1 B and C, respectively. The roles of these isoforms in RUNX1 autoregulation and downstream gene regulation in megakaryocytes and platelets are unknown. To understand the regulation of RUNX1 and its target genes by RUNX1 isoforms. We...
Jung, Minji Lee, Beom-Jin Lee, Sukhyang Shin, Jaekyu
Published in
The Annals of pharmacotherapy
While moderate-intensity statin therapy is recommended for primary prevention, statins may not be utilized at a recommended intensity due to dose-dependent adverse events, especially in an Asian population. However, evidence supporting the use of low-intensity statins in primary prevention is limited. We sought to compare clinical outcomes between ...
Mummery, Christine
Published in
BioEssays : news and reviews in molecular, cellular and developmental biology
Stem cell research is the product of cumulative, integrated effort between and within laboratories and disciplines. The many collaborative steps that lead to that special "Eureka moment", when something that has been a puzzle perhaps for years suddenly become clear, is among the greatest pleasures of a scientific career. In this essay, the serendip...
mohajeri, darya jahre, lisa maria bäuerle, alexander schieffers, theresa messiha, daniel rammos, christos teufel, martin rassaf, tienush lortz, julia
Background: Cardiovascular diseases (CVDs) are the leading causes of death globally. Managing risk factors and preventing atherosclerosis and its progress, especially with lifestyle changes, are highly important. Smartphone-based mobile health (mHealth) strategies allow easily accessible assistance for healthy nutrition. This study aimed to assess ...
alqulaity, malak yang, po
The generation of synthetic tabular data has emerged as a critical task in various fields, particularly in healthcare, where data privacy concerns limit the availability of real datasets for research and analysis. This paper presents an enhanced Conditional Generative Adversarial Network (GAN) architecture designed for generating high-quality synth...
zimbru, elena-larisa zimbru, răzvan-ionuț ordodi, valentin-laurențiu bojin, florina-maria crîsnic, daniela andor, minodora mirica, silvia-nicoleta huțu, ioan tănasie, gabriela haidar, laura
...
Background: A growing body of evidence links a high-fructose diet (HFrD) to metabolic disturbances, including inflammation, dyslipidemia, insulin resistance and also endothelial dysfunction, yet its role in allergic asthma remains underexplored. Considering that obesity and hypercholesterolemia exacerbate asthma by promoting systemic inflammation, ...
prouse, teagan majumder, samarpan majumder, rinku
Atherosclerosis and cardiovascular disease are associated with high morbidity and mortality in industrialized nations. The Tyro3, Axl, and Mer (TAM) family of receptor tyrosine kinases is involved in the amplification or resolution of atherosclerosis pathology and other cardiovascular pathology. The ligands of these receptors, Protein S (PS) and gr...
buelna-chontal, mabel
Atherosclerosis, a major cause of cardiovascular diseases, is influenced by modifiable factors such as adiposity and blood cholesterol. Diet is crucial in these areas, particularly regarding antioxidant, inflammatory, and obesity effects. Coffee, a globally popular stimulant beverage, has garnered significant attention for its potential impact on c...
crocco, paolina montesanto, alberto la grotta, rossella paparazzo, ersilia soraci, luca dato, serena passarino, giuseppe rose, giuseppina
Cardiovascular disease (CVD) is a major global health concern. The number of people with CVD is expected to rise due to aging populations and increasing risk factors such as obesity and diabetes. Identifying new molecular markers is crucial for early diagnosis and treatment. Among these, plasma levels of some miRNAs, specifically expressed in cardi...
chermiti, rania burtey, stéphane dou, laetitia
Cardiovascular disease (CVD) is a major complication of chronic kidney disease (CKD), despite improvements in patient care. Vascular inflammation is a crucial process in the pathogenesis of CVD and a critical factor in the cardiovascular complications in CKD patients. CKD promotes a pro-inflammatory environment that impacts the vascular wall, leadi...
