Fujii, Keitaro Morita, Shinkichi Mochizuki, Mai Shibuya-Takahashi, Rie Fujimori, Haruna Yamaguchi, Kazunori Abe, Jiro Yamazaki, Tomoko Imai, Takayuki Sugamura, Kazuo
...
Published in
Cancer science
Various proteins are highly expressed in cancer (e.g., epidermal growth factor receptor); however, the majority are also expressed in normal cells, although they may differ in expression intensity. Recently, we reported that CD271 (nerve growth factor receptor), a glycosylated protein, increases malignant behavior of cancer, particularly stemlike p...
Cheng, Xin Lou, Kecheng Ding, Liang Zou, Xiaofeng Huang, Ruohui Xu, Gang Zou, Junrong Zhang, Guoxi
Published in
Frontiers in Oncology
Bladder cancer (BC) is one of the world’s most frequent cancers. Surgery coupled with adjuvant platinum-based chemotherapy is the current standard of therapy for BC. However, a high proportion of patients progressed to chemotherapy-resistant or even neoplasm recurrence. Hence, identifying novel treatment targets is critical for clinical treatment. ...
Wang, Rui Yan, Zhaopeng
Published in
Cancer medicine
In this study, based on some clinical phenomena and recently published knowledge, we proposed our "conversion-deterioration-double mutation" theory, which provides a possible unifying explanation for the evolutionary process of colorectal cancer cells in the human body. In this theory, we proposed that there is a partial interconversion and a jump ...
Wang, S Zhang, M J Wu, Z Z Zhu, S W Wan, S C Zhang, B X Yang, Q C Xiao, Y Chen, L Sun, Z J
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Published in
Journal of dental research
Gasdermin E (GSDME), as the major executive protein of pyroptosis, has been considered to be linked to antitumor immunity in recent years. However, the role of GSDME in oral squamous cell carcinoma (OSCC) remains to be elucidated. Here, by using a human OSCC tissue microarray, human OSCC tissue, and Tgfbr1/Pten conditional knockout mice, we found t...
Chen, Tsung-Ming Huang, Chih-Ming Hsieh, Ming-Shou Lin, Chun-Shu Lee, Wei-Hwa Yeh, Chi-Tai Liu, Shao-Cheng
Published in
Aging
The exact mechanisms of Head and neck squamous carcinoma (HNSCC) chemoresistance and metastatic transformation remain unclear. In recent decades, members of the transient receptor potential (TRP) channel family have been proposed as potential biomarkers and/or drug targets in cancer treatment. First, in a TCGA cohort of HNSCC, TRPM7 is highly expre...
Chen, Mengqing Wang, Xue Wang, Wenjun Gui, Xuemei Li, Zhan
Published in
Frontiers in Immunology
Objective Lung adenocarcinoma (LUAD) is a familiar lung cancer with a very poor prognosis. This study investigated the immune- and stemness-related genes to develop model related with cancer immunity and prognosis in LUAD. Method The Cancer Genome Atlas (TCGA) was utilized for obtaining original transcriptome data and clinical information. Differen...
Ding, Jie Xu, Weiqiang Tan, Jing Liu, Zhifang Huang, Guoliang Wang, Shoushan He, Zhiwei
Published in
Frontiers in Chemistry
Antigen CD133 is a glycoprotein present on the surface of cancer stem cells (CSCs), which is a key molecule to regulate the fate of stem cells and a functional marker of stem cells. Herein, a novel fluorescence “turn-on” nano-aptamer sensor for quantifying CD133 was designed using hybridization between CD133-targeted aptamers and partially compleme...
Yue, Hanxun Hu, Zenan Hu, Rui Guo, Zeying Zheng, Ya Wang, Yuping Zhou, Yongning
Published in
Frontiers in Oncology
Aldehyde dehydrogenases 1 family member A1(ALDH1A1) gene codes a cytoplasmic enzyme and shows vital physiological and pathophysiological functions in many areas. ALDH1A1 plays important roles in various diseases, especially in cancers. We reviewed and summarized representative correlative studies and found that ALDH1A1 could induce cancers via the ...
césaire;, mathieu
Survival in unresectable locally advanced stage non-small cell lung cancer (NSCLC) patients remains poor despite chemoradiotherapy. Recently, adjuvant immunotherapy improved survival for these patients but we are still far from curing most of the patients with only a 57% survival remaining at 3 years. This poor survival is due to the resistance to ...
Tsubakihara, Yutaro Ohata, Yae Okita, Yukari Younis, Shady Eriksson, Jens Sellin, Mikael E Ren, Jiang Ten Dijke, Peter Miyazono, Kohei Hikita, Atsuhiko
...
Published in
Molecular oncology
Transforming growth factor β (TGFβ) induces epithelial-mesenchymal transition (EMT), which correlates with stemness and invasiveness. Mesenchymal-epithelial transition (MET) is induced by TGFβ withdrawal and correlates with metastatic colonization. Whether TGFβ promotes stemness and invasiveness simultaneously via EMT remains unclear. We establishe...
