Published in Genes
For a long time, the construction of complete reference genomes for complex eukaryotic genomes has been hindered by the limitations of sequencing technologies. Recently, the Pacific Biosciences (PacBio) HiFi data and Oxford Nanopore Technologies (ONT) Ultra-Long data, leveraging their respective advantages in accuracy and length, have provided an o...
Published in Frontiers in Endocrinology
Purpose Bone marrow adipocytes (BMAs) are the most plentiful cells in the bone marrow and function as an endocrine organ by producing fatty acids, cytokines, and adipokines. Consequently, BMAs can interact with tumor cells, influencing both tumor growth and the onset and progression of bone metastasis. This review aims to systematically evaluate th...
Published in Pharmaceutics
Plant and herbal essential oils (EOs) offer a wide range of pharmacological actions that include anticancer effects. Here, we evaluated the cytotoxic activity of EO from Lippia alba (chemotype linalool), L. alba (chemotype dihydrocarvone, LaDEO), Clinopodium nepeta (L.) Kuntze (CnEO), Eucalyptus globulus, Origanum × paniculatum, Mentha × piperita, ...
Published in Frontiers in Cell and Developmental Biology
Cancer progression and metastasis are processes heavily controlled by the integrin receptor family. Integrins are cell adhesion molecules that constitute the central components of mechanosensing complexes called focal adhesions, which connect the extracellular environment with the cell interior. Focal adhesions act as key players in cancer progress...
Published in Biochemistry. Biokhimiia
Development of oxidative/nitrosative stress associated with the activation of oncogenic pathways results from the increase in the generation of reactive oxygen and nitrogen species (ROS/RNS) in tumor cells, where they can have a dual effect. At high concentrations, ROS/RNS cause cell death and limit tumor growth at certain phases of its development...
Published in Acta Biologica Marisiensis
Despite the significant gains made in cancer therapy, cancer remains a major cause of global deaths due to rapid drug resistance. Therefore, urgent concerted efforts towards the discovery and development of newer and effective anticancer agents cannot be overemphasized. This study investigated in vitro cytotoxicity potential of methanol extracts of...
Published in Natural product research
Two new triterpenes, 3β, 7β-dihydroxyolean-12-en-11-one (1) and 3β-O-acetyl-7β-hydroxyolean-12-en-11-one (2), along with four known triterpenes 3β-hydroxyolean-12-en-11-one (3), β-amyrin (4), lup-20(29)-ene-1β, 3β-diol (5) and 1β, 3β-dihydroxy-urs-9(11)-12-diene (6), were isolated from the stems and leaves of Maytenus guangxiensis C. Y. Cheng et W....
Published in Frontiers in Cell and Developmental Biology
The posttranslational proteolytic cleavage is a unique and irreversible process that governs the function and half-life of numerous proteins. Thereby the role of the family of A disintegrin and metalloproteases (ADAMs) plays a leading part. A member of this family, ADAM8, has gained attention in regulating disorders, such as neurogenerative disease...
NAMEN: Splošni namen doktorske disertacije je bil preučiti molekularne mehanizme, prek katerih skeletne mišice uravnavajo delovanje z AMP-aktivirane protein kinaze (AMPK) v fizioloških in patofizioloških stanjih, katerih posledica je indukcija imunskega odziva. Poleg tega je bil cilj pojasniti tudi molekularne mehanizme, prek katerih farmakološki m...
Among the non-platinum antitumor agents, gold complexes have received increased attention owing to their strong antiproliferative effects, which generally occur through non-cisplatin-like mechanisms of action. Several studies have revealed that many cytotoxic gold compounds, such as N-heterocyclic carbene (NHC)-gold(I) complexes, are potent thiored...
