Chao, Min-Wu Lin, Tony Eight HuangFu, Wei-Chun Chang, Chao-Di Tu, Huang-Ju Chen, Liang-Chieh Yen, Shih-Chung Sung, Tzu-Ying Huang, Wei-Jan Yang, Chia-Ron
...
Published in
Journal of enzyme inhibition and medicinal chemistry
The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 kinase pathway is linked with cancer malignancy. A small-molecule inhibitor targeting the STE20 kinase...
Gorfe, Alemayehu A Cho, Kwang-Jin
Published in
Small GTPases
Activating somatic K-Ras mutations are associated with >15% all human tumors and up to 90% of specific tumor types such as pancreatic cancer. Successfully inhibiting abnormal K-Ras signaling would therefore be a game changer in cancer therapy. However, K-Ras has long been considered an undruggable target for various reasons. This view is now changi...
Elkefi, Safa Yu, Zhongyuan Asan, Onur
Published in
Journal of medical Internet research
Online medical records are being used to organize processes in clinical and outpatient settings and to forge doctor-patient communication techniques that build mutual understanding and trust. We aimed to understand the reasons why patients tend to avoid using online medical records and to compare the perceptions that patients have of online medical...
Kaur, Jatinder Bhardwaj, Atul Wuest, Frank
Published in
Chemistry (Weinheim an der Bergstrasse, Germany)
Live-cell imaging with fluorescent probes is an essential tool in chemical biology to visualize the dynamics of biological processes in real-time. Intracellular disease biomarker imaging remains a formidable challenge due to the intrinsic limitations of conventional fluorescent probes and the complex nature of cells. This work reports the in cellul...
Garassino, Marina Chiara Vyas, Malvika de Vries, Elisabeth Kanesvaran, Ravindran Giuliani, Rosa Peters, Solange
Published in
Annals of Oncology
Rhodes, Kelly R Isser, Ariel Hickey, John W Ben-Akiva, Elana Meyer, Randall A Kosmides, Alyssa K Livingston, Natalie K Tzeng, Stephany Y Schneck, Jonathan P Green, Jordan J
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Published in
ACS applied materials & interfaces
Biomimetic biomaterials are being actively explored in the context of cancer immunotherapy because of their ability to directly engage the immune system to generate antitumor responses. Unlike cellular therapies, biomaterial-based immunotherapies can be precisely engineered to exhibit defined characteristics including biodegradability, physical siz...
Cardona-G, Wilson Herrera-R, Angie Castrillón-L, Wilson Ramírez-Malule, Howard
Published in
Current medicinal chemistry
Cancer still continues as an important cause of death worldwide. Thus, several conventional anticancer treatments are widely used, however, most of them display low selectivity against malignant cells and induce many adverse side effects. Among these, the use of therapies based on 5-Fluorouracil (5-FU) has been one of the most efficient, with a bro...
Ryba, Marlena M Lo, Stephen B Andersen, Barbara L
Published in
Translational behavioral medicine
The ultimate aim of dissemination and implementation of empirically supported treatments (ESTs) in behavioral medicine is (a) sustainability of the therapist/provider's EST usage and (b) sustainment of EST delivery in the setting. Thus far, sustainability has been understudied, and the therapist and setting variables that may be influential are unc...
Walton, Katherine D. Gumucio, Deborah L.
The hedgehog (Hh) signaling pathway plays several diverse regulatory and patterning roles during organogenesis of the intestine and in the regulation of adult intestinal homeostasis. In the embryo, fetus, and adult, intestinal Hh signaling is paracrine: Hh ligands are expressed in the endodermally derived epithelium, while signal transduction is co...
Giesen, Nicola Sprute, Rosanne Rüthrich, Maria Khodamoradi, Yascha Mellinghoff, Sibylle C. Beutel, Gernot Lueck, Catherina Koldehoff, Michael Hentrich, Marcus Sandherr, Michael
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Published in
European Journal of Cancer
The worldwide spread of SARS-CoV-2 and the associated infectious disease COVID-19 has posed a unique challenge to medical staff, patients and their families. Cancer patients, particularly those with haematologic malignancies, have been identified to be at high risk to develop severe COVID-19. Since publication of our previous guideline on evidence-...
