Chao, Min-Wu Lin, Tony Eight HuangFu, Wei-Chun Chang, Chao-Di Tu, Huang-Ju Chen, Liang-Chieh Yen, Shih-Chung Sung, Tzu-Ying Huang, Wei-Jan Yang, Chia-Ron
...
Published in
Journal of enzyme inhibition and medicinal chemistry
The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 kinase pathway is linked with cancer malignancy. A small-molecule inhibitor targeting the STE20 kinase...
Kim, Yoo-Ah Leiserson, Mark D.M. Moorjani, Priya Sharan, Roded Wojtowicz, Damian Przytycka, Teresa M.
Published in
Annual Review of Biomedical Data Science
Mutations are the driving force of evolution, yet they underlie many diseases, in particular, cancer. They are thought to arise from a combination of stochastic errors in DNA processing, naturally occurring DNA damage (e.g., the spontaneous deamination of methylated CpG sites), replication errors, and dysregulation of DNA repair mechanisms. High-th...
Cheng, Nuojin Schulte, Ashley J Santosa, Fadil Kim, Jong Hyuk
Published in
Briefings in bioinformatics
Angiosarcomas are soft-tissue sarcomas that form malignant vascular tissues. Angiosarcomas are very rare, and due to their aggressive behavior and high metastatic propensity, they have poor clinical outcomes. Hemangiosarcomas commonly occur in domestic dogs, and share pathological and clinical features with human angiosarcomas. Typical pathognomoni...
Toplak, Žan
Kalijevi kanali se vpletajo v raznolike celične procese s primarno vlogo pri vzdrževanju ionske homeostaze. Ključno vlogo imajo tudi pri patofiziologiji napredovanja rakavih obolenj. Napetostno odvisni kalijev kanal hEAG1 je primer kanala, ki se vpleta v različne procese razvoja raka, saj se njegovo povečano izražanje pojavlja pri večini vrst raka ...
Martins, Waleska K. Fader, Claudio M. Morselli, Eugenia Grasso, Daniel
Published in
Frontiers in Oncology
Kartikasari, Apriliana E. R. Huertas, Cesar S. Mitchell, Arnan Plebanski, Magdalena
Published in
Frontiers in Oncology
Chronic inflammation generated by the tumor microenvironment is known to drive cancer initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor microenvironment promotes the secretion of diverse cytokines, in different types and stages of cancers. These cytokines may inhibit tumor development but alternatively may co...
Kostecka, Laurie G. Pienta, Kenneth J. Amend, Sarah R.
Published in
Frontiers in Ecology and Evolution
Dormancy is a key survival strategy in many organisms across the tree of life. Organisms that utilize some type of dormancy (hibernation, aestivation, brumation, diapause, and quiescence) are able to survive in habitats that would otherwise be uninhabitable. Induction into dormant states is typically caused by environmental stress. While organisms ...
Sampaio, Laeza Alves Pina, Lícia Tairiny Santos Serafini, Mairim Russo Tavares, Débora dos Santos Guimarães, Adriana Gibara
Published in
Frontiers in Pharmacology
Background: It is estimated that one in five people worldwide faces a diagnosis of a malignant neoplasm during their lifetime. Carvacrol and its isomer, thymol, are natural compounds that act against several diseases, including cancer. Thus, this systematic review aimed to examine and synthesize the knowledge on the antitumor effects of carvacrol a...
Mondal, Arijit Banerjee, Sabyasachi Bose, Sankhadip Das, Partha Pratim Sandberg, Elise N. Atanasov, Atanas G. Bishayee, Anupam
Published in
Frontiers in Oncology
Background The banana (Musa spp.) plant produces elongated and edible fruit. The two main parthenocarpic species of banana are Musa accuminata Colla and Musa balbisiana Colla. There are several health-promoting and disease-preventing effects of Musa accuminata Colla, which are attributed to its important bioactive compounds, including phenolics, ca...
Achilonu, Okechinyere J. Fabian, June Bebington, Brendan Singh, Elvira Eijkemans, M. J. C. Musenge, Eustasius
Published in
Frontiers in Public Health
Background: South Africa (SA) has the highest incidence of colorectal cancer (CRC) in Sub-Saharan Africa (SSA). However, there is limited research on CRC recurrence and survival in SA. CRC recurrence and overall survival are highly variable across studies. Accurate prediction of patients at risk can enhance clinical expectations and decisions withi...
