Published in Cell metabolism
Caloric restriction rapidly reverses type 2 diabetes (T2D), but the mechanism(s) of this reversal are poorly understood. Here we show that 3 days of a very-low-calorie diet (VLCD, one-quarter their typical intake) lowered plasma glucose and insulin concentrations in a rat model of T2D without altering body weight. The lower plasma glucose was assoc...
The growth hormone–insulin-like growth factor-1 (GH–IGF-1) axis plays an important role in the effects of caloric restriction (CR) on lifespan extension and may elicit effects on bone metabolism in CR animals. We compared the effects of the GH–IGF-1 axis suppression and CR on bone metabolism. We used Wistar rats fed ad libitum (control group) or fe...
The growth hormone–insulin-like growth factor-1 (GH–IGF-1) axis plays an important role in the effects of caloric restriction (CR) on lifespan extension and may elicit effects on bone metabolism in CR animals. We compared the effects of the GH–IGF-1 axis suppression and CR on bone metabolism. We used Wistar rats fed ad libitum (control group) or fe...
The growth hormone–insulin-like growth factor-1 (GH–IGF-1) axis plays an important role in the effects of caloric restriction (CR) on lifespan extension and may elicit effects on bone metabolism in CR animals. We compared the effects of the GH–IGF-1 axis suppression and CR on bone metabolism. We used Wistar rats fed ad libitum (control group) or fe...
Published in Journal of clinical biochemistry and nutrition
The effect of 1-deoxynojirimycin, a caloric restriction mimetic, was examined in ICR mice with azoxymethane dextran sodium sulfate-induced colorectal cancer. Azoxymethane is a carcinogen (10 mg/kg body weight), and 2% dextran sodium sulfate (w/v) used as a colitis-inducing agent. Mice were separated into 5 groups: a group without colorectal cancer ...
Published in The journals of gerontology. Series A, Biological sciences and medical sciences
These results provide proof-of-concept that p16 INK4a+cells in thigh adipose are associated with physical function, and may be sensitive to change with RT±CR in overweight/obese older women.
Published in Aging cell
Adipose tissue expansion has been associated with system-wide metabolic dysfunction and increased vulnerability to diabetes, cancer, and cardiovascular disease. A reduction in adiposity is a hallmark of caloric restriction (CR), an intervention that extends longevity and delays the onset of these same age-related conditions. Despite these parallels...
Published in American journal of physiology. Regulatory, integrative and comparative physiology
Caloric restriction decreases skeletal muscle mass in mammals, principally due to a reduction in fiber size. The effect of suboptimal nutrient intake on skeletal muscle metabolic properties in neonatal calves was examined. The longissimus muscle (LM) was collected after a control (CON) or caloric restricted (CR) diet was cosnumed for 8 wk and muscl...
Published in International journal of epidemiology
Our findings suggest that severe exposure to a short period of caloric restriction in pre-adult women may relate to CRC risk decades later.
Citation: Acta Medica Nagasakiensia, 61(2), pp.49−54; 2017
