Pilch, Kjara S Ramgoolam, Krishma H Dolphin, Annette C
Published in
The Journal of physiology
In the mammalian brain, presynaptic CaV 2 channels play a pivotal role in synaptic transmission by mediating fast neurotransmitter exocytosis via influx of Ca2+ into the active zone of presynaptic terminals. However, the distribution and modulation of CaV 2.2 channels at plastic hippocampal synapses remains to be elucidated. Here, we assess CaV 2.2...
Barry, Joshua Peng, Allison Levine, Michael S. Cepeda, Carlos
Published in
Frontiers in Neuroscience
Huntington’s disease (HD) is a fatal, hereditary neurodegenerative disorder that causes chorea, cognitive deficits, and psychiatric symptoms. It is characterized by accumulation of mutant Htt protein, which primarily impacts striatal medium-sized spiny neurons (MSNs), as well as cortical pyramidal neurons (CPNs), causing synapse loss and eventually...
de Kraker, Leander Seignette, Koen Thamizharasu, Premnath van den Boom, Bastijn J G Ferreira Pica, Ildefonso Willuhn, Ingo Levelt, Christiaan N Togt, Chris van der
Published in
Cell reports methods
Imaging calcium signals in neurons of animals using single- or multi-photon microscopy facilitates the study of coding in large neural populations. Such experiments produce massive datasets requiring powerful methods to extract responses from hundreds of neurons. We present SpecSeg, an open-source toolbox for (1) segmentation of regions of interest...
Pechuk, Vladyslava Goldman, Gal Salzberg, Yehuda Chaubey, Aditi H Bola, R Aaron Hoffman, Jonathon R Endreson, Morgan L Miller, Renee M Reger, Noah J Portman, Douglas S
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Published in
Current biology : CB
The effect of the detailed connectivity of a neural circuit on its function and the resulting behavior of the organism is a key question in many neural systems. Here, we study the circuit for nociception in C. elegans, which is composed of the same neurons in the two sexes that are wired differently. We show that the nociceptive sensory neurons res...
Han, GoEun Matsumoto, Sumire Diaz, Javier Greene, Robert W. Vogt, Kaspar E.
Published in
Frontiers in Neuroscience
Non-rapid eye movement (NREM) sleep is tightly homeostatically regulated and essential for survival. In the electroencephalogram (EEG), oscillations in the delta (0.5–4 Hz) range are prominent during NREM sleep. These delta oscillations are, to date, the best indicator for homeostatic sleep regulation; they are increased after prolonged waking and ...
Roussel, Edith Sandoz, Jean-Christophe Giurfa, Martin
Published in
Frontiers in Behavioral Neuroscience
Plasticity in the honeybee brain has been studied using the appetitive olfactory conditioning of the proboscis extension reflex, in which a bee learns the association between an odor and a sucrose reward. In this framework, coupling behavioral measurements of proboscis extension and invasive recordings of neural activity has been difficult because ...
Zhang, Lu Chen, Ruijia Li, Xiaoyang Xu, Xiaoyong Xu, Zhiping Cheng, Jiagao Wang, Yanli Li, Yuxin Shao, XuSheng Li, Zhong
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Published in
Journal of agricultural and food chemistry
To develop potent and environment-friendly insecticides, novel N-pyridylpyrazole amide derivatives containing a phthalimide were designed and synthesized. The preliminary bioassay results showed that most of the target compounds exhibited good insecticidal activities. For oriental armyworm (Mythimna separata), compounds E5, E29, E30, and E33 displa...
Benisty, Hadas Song, Alexander Mishne, Gal Charles, Adam S
Functional optical imaging in neuroscience is rapidly growing with the development of optical systems and fluorescence indicators. To realize the potential of these massive spatiotemporal datasets for relating neuronal activity to behavior and stimuli and uncovering local circuits in the brain, accurate automated processing is increasingly essentia...
Li, Zhiling Boesmans, Werend Kazwiny, Youcef Hao, Marlene M Vanden Berghe, Pieter
Published in
American journal of physiology. Gastrointestinal and liver physiology
Live calcium imaging is often used as a proxy for electrophysiological measurements and has been a valuable tool that allows simultaneous analysis of neuronal activity in multiple cells at the population level. In the enteric nervous system, there are two main electrophysiological classes of neurons, after-hyperpolarizing (AH)- and synaptic (S)-neu...
Özsoy, Çağla Hotz, Adriana L. Rieser, Nicolas N. Chen, Zhenyue Deán-Ben, Xosé Luís Neuhauss, Stephan C. F. Razansky, Daniel
Published in
Frontiers in Molecular Neuroscience
Fast three-dimensional imaging of freely-swimming zebrafish is essential to understand the link between neuronal activity and behavioral changes during epileptic seizures. Studying the complex spatiotemporal patterns of neuronal activity at the whole-brain or -body level typically requires physical restraint, thus hindering the observation of unper...
