Rybnicek, Jonas Samtleben, Samira Herrera-Cruz, Maria Sol Simmen, Thomas
Published in
Small GTPases
We have shown that multiple sclerosis (MS) and endoplasmic reticulum (ER) stress induce Rab32, an ER/mitochondria-localized small GTPase. High levels of both dominant-active (Q85L) or dominant-inactive (T39N) Rab32 are toxic to neurons. While Rab32Q85L interacts with its effector Drp1 to promote mitochondria fission, it is unclear how Rab32T39N cou...
Skok, Sara
V magistrski nalogi smo preverjali odziv celic in protoplastov, pridobljenih iz kalusnega tkiva koruze, na dodatek acetilholina in agonistov acetilholinskih receptorjev. Razvoj kalusa smo inducirali z nacepom mladih poganjkov na gojišče Murashige-Skoog z dodatkom sintetičnega avksina 2,4-D [3 mg/L]. Odzivanje celic in protoplastov s povišanjem [Ca2...
aguayo-ortiz, rodrigo espinoza-fonseca, l. michel
Sarcoendoplasmic reticulum calcium ATPase (SERCA), a member of the P-type ATPase family of ion and lipid pumps, is responsible for the active transport of Ca2+ from the cytoplasm into the sarcoplasmic reticulum lumen of muscle cells, into the endoplasmic reticulum (ER) of non-muscle cells. X-ray crystallography has proven to be an invaluable tool i...
milanesi, riccardo coccetti, paola tripodi, farida
Robust biological systems are able to adapt to internal and environmental perturbations. This is ensured by a thick crosstalk between metabolism and signal transduction pathways, through which cell cycle progression, cell metabolism and growth are coordinated. Although several reports describe the control of cell signaling on metabolism (mainly thr...
Trempel, Fabian Eschen-Lippold, Lennart Bauer, Nicole Ranf, Stefanie Westphal, Lore Scheel, Dierk Lee, Justin
Published in
FEBS letters
Changes in cellular calcium levels are one of the earliest signalling events in plants exposed to pathogens or other exogenous factors. In a genetic screen, we identified an Arabidopsis thaliana 'changed calcium elevation 1' (cce1) mutant with attenuated calcium response to the bacterial flagellin flg22 peptide and several other elicitors. Whole-ge...
Gažarová, M. Kopčeková, J. Mrázová, J. Chlebo, P.
Published in
Scientia Agriculturae Bohemica
Healthy nutrition requires the intake of all macronutrients and micronutrients in optimal ratio and quantity. Nowadays, many people tend to gluten-free food without health and medical reasons. Many gluten-free products are nutritionally poorer than gluten-containing analogues. Although in many cases gluten-free products are nutritionally rich (eith...
Kim, Yong-Gun Kim, Myoung Ok Kim, Sung-Hyun Kim, Hyo Jeong Pokhrel, Nitin Kumar Lee, Ji Hye Lee, Heon-Jin Kim, Jae-Young Lee, Youngkyun
Published in
Journal of periodontology
Periodontitis is an inflammatory disease of the tissues surrounding teeth that causes destruction of connective tissues. During the progress of periodontitis, osteoclasts are solely accountable for the resorption of alveolar bones that leads to the loss of teeth if not properly treated. Thus, the development of effective anti-resorptive therapies w...
lemtiri-chlieh, fouad arold, stefan t. gehring, chris
Hyperpolarization-activated calcium channels (HACCs) are found in the plasma membrane and tonoplast of many plant cell types, where they have an important role in Ca2+-dependent signalling. The unusual gating properties of HACCs in plants, i.e., activation by membrane hyperpolarization rather than depolarization, dictates that HACCs are normally op...
santambrogio, paolo ripamonti, maddalena paolizzi, chiara panteghini, celeste carecchio, miryam chiapparini, luisa raimondi, marzia rubio, alicia di meo, ivano cozzi, anna
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Pantothenate Kinase-associated Neurodegeneration (PKAN) belongs to a wide spectrum of diseases characterized by brain iron accumulation and extrapyramidal motor signs. PKAN is caused by mutations in PANK2, encoding the mitochondrial pantothenate kinase 2, which is the first enzyme of the biosynthesis of Coenzyme A. We established and characterized ...
wasilewska, iga gupta, rishikesh kumar wojtaś, bartosz palchevska, oksana kuźnicki, jacek
In neurons, stromal interaction molecule (STIM) proteins regulate store-operated Ca2+ entry (SOCE) and are involved in calcium signaling pathways. However, STIM activity in neurological diseases is unclear and should be clarified by studies that are performed in vivo rather than in cultured cells in vitro. The present study investigated the role of...
