Reyes Gaido, Oscar E. Nkashama, Lubika J. Schole, Kate L. Wang, Qinchuan Umapathi, Priya Mesubi, Olurotimi O. Konstantinidis, Klitos Luczak, Elizabeth D. Anderson, Mark E.
CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly validated signal for promoting a variety of common diseases, particularly in the cardiovascular system. Despite substantial amounts of convincing preclinical data, CaMKII inhibitors have yet to emerge in clinical practice. Therapeutic inhibition is challen...
Wei, Qinling Xie, Keqin Wang, Hongfei Shao, Xingfeng Wei, Yingying Chen, Yi Jiang, Shu Cao, Mengze Chen, Jisuan Xu, Feng
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Published in
Plants (Basel, Switzerland)
The effect of fructose on γ-aminobutyric acid (GABA) content and its metabolic pathway in broccoli sprouts was investigated. The results demonstrated that the fructose treatment not only significantly increased the fresh weight, GABA, and glutamate contents in sprouts, but also promoted the activity of glutamic acid decarboxylase (GAD) and the expr...
Pongrac, Paula Kelemen, Mitja Vogel-Mikuš, Katarina Vavpetič, Primož Pelicon, Primož Žurga, Paula Vidović, Nikolina Polić Pasković, Marija Goreta Ban, Smiljana Lukić, Igor
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Olive tree (Olea europaea L.) leaves have recently been recognised as a valuable source in cosmetic and pharmaceutical industry as well as in preparation of health-supporting beverages. Little is known about the element composition of olive leaves and almost nothing about tissue-specific allocation of elements. Element composition in tissue-specifi...
Matthus, Elsa Ning, Youzheng Shafiq, Fahad Davies, Julia M.
Published in
Frontiers in Plant Science
Phosphate deprivation compromises plant productivity and modulates immunity. DAMP signalling by extracellular ATP (eATP) could be compromised under phosphate deprivation by the lowered production of cytosolic ATP and the need to salvage eATP as a nutritional phosphate source. Phosphate-starved roots of Arabidopsis can still sense eATP, indicating r...
Sapuła, Paulina Bialik-Wąs, Katarzyna Malarz, Katarzyna
Published in
Pharmaceutics
The main aim of this review is to assess the potential use of natural cross-linking agents, such as genipin, citric acid, tannic acid, epigallocatechin gallate, and vanillin in preparing chemically cross-linked hydrogels for the biomedical, pharmaceutical, and cosmetic industries. Chemical cross-linking is one of the most important methods that is ...
Allan, Claudia Tayagui, Ayelen Hornung, Rainer Nock, Volker Meisrimler, Claudia-Nicole
Published in
Frontiers in Plant Science
One sentence summary: Bi-directional-dual-flow-RootChip to track calcium signatures in Arabidopsis primary roots responding to osmotic stress. Plant growth and survival is fundamentally linked with the ability to detect and respond to abiotic and biotic factors. Cytosolic free calcium (Ca2+) is a key messenger in signal transduction pathways associ...
Yamanaka, Tomoyasu Ueki, Takatoshi Mase, Mitsuhito Inoue, Koichi
Published in
Frontiers in Pharmacology
Modern western dietary habits and low physical activity cause metabolic abnormalities and abnormally elevated levels of metabolites such as low-density lipoprotein, which can lead to immune cell activation, and inflammatory reactions, and atherosclerosis. Appropriate stimulation of vascular endothelial cells can confer protective responses against ...
Chun, Byeong J. Aryal, Surya P. Varughese, Peter Sun, Bin Bruno, Joshua A. Richards, Chris I. Bachstetter, Adam D. Kekenes-Huskey, Peter M.
Published in
Frontiers in Physiology
Adenosine triphosphate (ATP) and its metabolites drive microglia migration and cytokine production by activating P2X- and P2Y- class purinergic receptors. Purinergic receptor activation gives rise to diverse intracellular calcium (Ca2+ signals, or waveforms, that differ in amplitude, duration, and frequency. Whether and how these characteristics of...
Duda, Teresa Sharma, Rameshwar K.
Published in
Frontiers in Molecular Neuroscience
One monumental discovery in the field of cell biology is the establishment of the membrane guanylate cyclase signal transduction system. Decoding its fundamental, molecular, biochemical, and genetic features revolutionized the processes of developing therapies for diseases of endocrinology, cardio-vasculature, and sensory neurons; lastly, it has st...
Bykhovskaia, Maria
Published in
Frontiers in Molecular Neuroscience
Nerve terminals release neuronal transmitters at morphological specializations known as active zones (AZs). Synaptic vesicle fusion at individual AZs is probabilistic, and this property is fundamental for the neuronal information transfer. Until recently, a lack of appropriate tools limited the studies of stochastic properties of neuronal secretion...