Kanunnikov, M M Rakhmanova, J Z Levkovsky, N V Vafina, A I Goloshapov, O V Shchegoleva, T S Vlasova, Yu Yu Paina, O V Morozova, E V Zubarovskaya, L S
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Published in
Clinical transplantation
Transplant-associated thrombotic microangiopathy (TA-TMA) is a specific complication of allogeneic hematopoietic cell transplantation with a multifactorial etiology. There is little evidence published regarding the efficacy and factors influencing the outcome of substitution of calcineurin inhibitors (CNIs) with other agentsas a widely accepted pra...
Govender, Lerisa Mikulic, Josip Wyss, Jean-Christophe Gaide, Olivier Thome, Margot Golshayan, Dela
Published in
Frontiers in Immunology
Strategies targeting T cells are the cornerstone of immunosuppression after solid organ transplantation. The transcription factor NF-κB is a key regulator of downstream T-cell activation and induction of inflammatory mediators; its full activation via antigen receptor engagement requires both the scaffold and the protease activity of the paracaspas...
Schoot, Tessa S. Kerckhoffs, Angèle P. M. Hilbrands, Luuk B. van Marum, Rob J.
Published in
Frontiers in Pharmacology
Background Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is currently unknown whether immunosuppressive drugs are advantageous or detrimental in patients with COVID-19. Immunosuppressive drugs could be harmful in the initial phase of COVID-19. In this phase, the host immune respons...
Glowacka, Paulina Rudnicka, Lidia Warszawik-Hendzel, Olga Sikora, Mariusz Goldust, Mohamad Gajda, Patrycja Stochmal, Anna Blicharz, Leszek Rakowska, Adriana Olszewska, Malgorzata
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Published in
Biology
This review updates current knowledge regarding the risk of viral infections, including COVID-19, in patients treated with cyclosporine. We also shortly refer to bacterial infections and parasitic infestations in patients treated with cyclosporin. Cyclosporine is an immunosuppressive drug, which is widely used in medicine, including in the treatmen...
Thongprayoon, Charat Hansrivijit, Panupong Kovvuru, Karthik Kanduri, Swetha R. Bathini, Tarun Pivovarova, Aleksandra Smith, Justin R. Cheungpasitporn, Wisit
Published in
Journal of Clinical Medicine
Tacrolimus is a first-line calcineurin inhibitor (CNI) and an integral part of the immunosuppressive strategy in solid organ transplantation. Being a dose-critical drug, tacrolimus has a narrow therapeutic index that necessitates periodic monitoring to maintain the drug’s efficacy and reduce the consequences of overexposure. Tacrolimus is character...
Cavagna, Lorenzo Seminari, Elena Zanframundo, Giovanni Gregorini, Marilena Di Matteo, Angela Rampino, Teresa Montecucco, Carlomaurizio Pelenghi, Stefano Cattadori, Barbara Pattonieri, Eleonora Francesca
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Published in
Microorganisms
The role of immunosuppression in SARS-CoV-2-related disease (COVID-19) is a matter of debate. We here describe the course and the outcome of COVID-19 in a cohort of patients undergoing treatment with calcineurin inhibitors. In this monocentric cohort study, data were collected from the COVID-19 outbreak in Italy up to 28 April 2020. Patients were f...
Abbasi Dezfouli, Sepehr Nikdad, Mohammadsadegh Ghamarnejad, Omid Khajeh, Elias Arefidoust, Alireza Mohammadi, Sara Majlesara, Ali Sabagh, Mohammadsadegh Gharabaghi, Negin Kentar, Modar
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Published in
Frontiers in Immunology
Background: The systemic inflammatory cascade triggered in donors after brain death enhances the ischemia-reperfusion injury after organ transplantation. Intravenous steroids are routinely used in the intensive care units for the donor preconditioning. Immunosuppressive medications could be potentially used for this purpose as well. Data regarding ...
Pape, Simon Nevens, Frederik Verslype, Chris Mertens, Caroline Drenth, Joost P H Tjwa, Eric T T L
Published in
European journal of gastroenterology & hepatology
Therapy for autoimmune hepatitis (AIH) consists of steroid induction therapy, followed by maintenance therapy with azathioprine. However, up to 20% of patients experience either insufficient response or intolerance on first-line therapy. Calcineurin inhibitors (CNIs) are frequently used when first-line therapy fails. Although a number of studies re...
Heymann, Warren R
Published in
Journal of the American Academy of Dermatology
Elens, Laure Langman, Loralie J. Hesselink, Dennis A. Bergan, Stein Moes, Dirk Jan A.R. Molinaro, Mariadelfina Venkataramanan, Raman Lemaitre, Florian
Published in
Therapeutic Drug Monitoring
COVID-19 is a novel infectious disease caused by the severe acute respiratory distress (SARS)-coronavirus-2 (SARS-CoV-2). Several therapeutic options are currently emerging but none with universal consensus or proven efficacy. Solid organ transplant recipients are perceived to be at increased risk of severe COVID-19 because of their immunosuppresse...
